Search Results - "Reid, Robert C."

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells by Mak, Jeffrey Y. W., Xu, Weijun, Reid, Robert C., Corbett, Alexandra J., Meehan, Bronwyn S., Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong, Fairlie, David P.

“…Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6- D -ribitylaminouracil (a vitamin B2…”
Get full text

C5aR and C3aR antagonists each inhibit diet‐induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling by Lim, Junxian, Iyer, Abishek, Suen, Jacky Y., Seow, Vernon, Reid, Robert C., Brown, Lindsay, Fairlie, David P.

“…Mammalian survival depends on metabolizing nutrients, storing energy, and combating infection. Complement activation in blood triggers energy‐depleting immune…”
Get full text

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS by Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P., Sweet, Matthew J.

“…Selective inhibitor studies in macrophages implicate class II HDAC enzymes in TLR‐mediated inflammatory pathways and class I HDACs as negative regulators…”
Get full text

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice by Do, Anh, Reid, Robert C, Lohman, Rink-Jan, Sweet, Matthew J, Fairlie, David P, Iyer, Abishek

“…Small molecule histone deacetylase (HDAC) inhibitors with anti-inflammatory activity may be candidates for targeting intestinal inflammatory pathways in…”
Get more information

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages by Wu, Kai-Chen, Condon, Nicholas D, Hill, Timothy A., Reid, Robert C., Fairlie, David P., Lim, Junxian

“…Abstract Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of…”
Get full text

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA‐salt hypertensive rats by Iyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T, Reid, Robert C, Halili, Maria A, Fairlie, David P, Brown, Lindsay

“…Background and purpose:  Histone deacetylases (HDACs) silence genes by deacetylating lysine residues in histones and other proteins. HDAC inhibitors represent…”
Get full text

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a by Lohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek, Fairlie, David P.

“…Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form…”
Get full text

Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation by Sinniah, Enakshi, Wu, Zhixuan, Shen, Sophie, Naval-Sanchez, Marina, Chen, Xiaoli, Lim, Junxian, Helfer, Abbigail, Iyer, Abishek, Tng, Jiahui, Lucke, Andrew J., Reid, Robert C., Redd, Meredith A., Nefzger, Christian M., Fairlie, David P., Palpant, Nathan J.

“…Histone deacetylases (HDACs) are a class of enzymes that control chromatin state and influence cell fate. We evaluated the chromatin accessibility and…”
Get full text

Towards isozyme-selective HDAC inhibitors for interrogating disease by Gupta, Praveer, Reid, Robert C, Iyer, Abishek, Sweet, Matthew J, Fairlie, David P

“…Histone deacetylase (HDAC) enzymes have emerged as promising targets for the treatment of a wide range of human diseases, including cancers, inflammatory and…”
Get more information

Inhibitors of secretory phospholipase A2 group IIA by Reid, Robert C

“…Phospholipases A2 cleave membrane phospholipids to release arachidonic acid, the precursor to a large family of pro-inflammatory eicosanoids including…”
Get more information

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats by LYER, Abishek, LIM, Junxian, POUDYAL, Hemant, REID, Robert C, SUEN, Jacky Y, WEBSTER, Julie, PRINS, Johannes B, WHITEHEAD, Jonathan P, FAIRLIE, David P, BROWN, Lindsay

“…Obesity, type 2 diabetes, and cardiovascular disease correlate with infiltration to adipose tissue of different immune cells, with uncertain influences on…”
Get full text

Alpine Ski Motion Characteristics in Slalom by Reid, Robert C, Haugen, Per, Gilgien, Matthias, Kipp, Ronald W, Smith, Gerald Allen

“…Important insight into ski function, and ultimately skier technique and tactics, can be gained by studying how measured ski trajectories compare to predictions…”
Get full text

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis by Kim, Soo-Hyun, Redvers, Richard P, Chi, Lap Hing, Ling, Xiawei, Lucke, Andrew J, Reid, Robert C, Fairlie, David P, Martin, Ana Carolina Baptista Moreno, Anderson, Robin L, Denoyer, Delphine, Pouliot, Normand

“…Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the genes and mechanisms regulating…”
Get full text

Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice by Chua, Ming Jang, Tng, Jiahui, Hesping, Eva, Fisher, Gillian M., Goodman, Christopher D., Skinner-Adams, Tina, Do, Darren, Lucke, Andrew J., Reid, Robert C., Fairlie, David P., Andrews, Katherine T.

“…Malaria is caused by infection with Plasmodium parasites and results in significant health and economic impacts. Malaria eradication is hampered by parasite…”
Get full text

Potencies of Human Immunodeficiency Virus Protease Inhibitors In Vitro against Plasmodium falciparum and In Vivo against Murine Malaria by ANDREWS, Katherine T, FAIRLIE, David P, STOERMER, Martin J, SKINNER-ADAMS, Tina, BERRY, Colin, MCCARTHY, James S, MADALA, Praveen K, RAY, John, WYATT, David M, HILTON, Petrina M, MELVILLE, Lewis A, BEATTIE, Lynette, GARDINER, Donald L, REID, Robert C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor by Scully, Conor C. G, Blakeney, Jade S, Singh, Ranee, Hoang, Huy N, Abbenante, Giovanni, Reid, Robert C, Fairlie, David P

“…Human anaphylatoxin C3a, formed through cleavage of complement protein C3, is a potent effector of innate immunity via activation of its G protein coupled…”
Get full text

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina by Bagnall, Neil H., Hines, Barney M., Lucke, Andrew J., Gupta, Praveer K., Reid, Robert C., Fairlie, David P., Kotze, Andrew C.

“…Histone deacetylase inhibitors (HDACi) are being investigated for the control of various human parasites. Here we investigate their potential as insecticides…”
Get full text

The Role of the N-terminal Domain of the Complement Fragment Receptor C5L2 in Ligand Binding by Scola, Anne-Marie, Higginbottom, Adrian, Partridge, Lynda J., Reid, Robert C., Woodruff, Trent, Taylor, Stephen M., Fairlie, David P., Monk, Peter N.

“…C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg. The…”
Get full text

A Potent Human C5a Receptor Antagonist Protects against Disease Pathology in a Rat Model of Inflammatory Bowel Disease by Woodruff, Trent M, Arumugam, Thiruma V, Shiels, Ian A, Reid, Robert C, Fairlie, David P, Taylor, Stephen M

“…The complement system is implicated in the pathogenesis of human inflammatory bowel disease, but the specific role of C5a has never been examined. We have…”
Get full text

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina by Kotze, Andrew C., Hines, Barney M., Bagnall, Neil H., Anstead, Clare A., Gupta, Praveer, Reid, Robert C., Ruffell, Angela P., Fairlie, David P.

“…The Australian sheep blowfly, Lucilia cuprina, is an ecto-parasite that causes significant economic losses in the sheep industry. Emerging resistance to…”
Get full text