Search Results - "Reid, Paul R."

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model by Price, Daniel J., Drewry, David H., Schaller, Lee T., Thompson, Brian D., Reid, Paul R., Maloney, Patrick R., Liang, Xi, Banker, Periette, Buckholz, Richard G., Selley, Paula K., McDonald, Octerloney B., Smith, Jeffery L., Shearer, Todd W., Cox, Richard F., Williams, Shawn P., Reid, Robert A., Tacconi, Stefano, Faggioni, Federico, Piubelli, Chiara, Sartori, Ilaria, Tessari, Michela, Wang, Tony Y.

“…[Display omitted] Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients…”
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Allosteric antagonism of insect odorant receptor ion channels by Jones, Patrick L, Pask, Gregory M, Romaine, Ian M, Taylor, Robert W, Reid, Paul R, Waterson, Alex G, Sulikowski, Gary A, Zwiebel, Laurence J

“…At a molecular level, insects utilize members of several highly divergent and unrelated families of cell-surface chemosensory receptors for detection of…”
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Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus by Mike, Laura A., Dutter, Brendan F., Stauff, Devin L., Moore, Jessica L., Vitko, Nicholas P., Aranmolate, Olusegun, Kehl-Fie, Thomas E., Sullivan, Sarah, Reid, Paul R., DuBois, Jennifer L., Richardson, Anthony R., Caprioli, Richard M., Sulikowski, Gary A., Skaar, Eric P.

“…Staphylococcus aureus is a significant infectious threat to global public health. Acquisition or synthesis of heme is required for S. aureus to capture energy…”
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Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists by Zuercher, William J, Buckholz, Richard G, Campobasso, Nino, Collins, Jon L, Galardi, Cristin M, Gampe, Robert T, Hyatt, Stephen M, Merrihew, Susan L, Moore, John T, Oplinger, Jeffrey A, Reid, Paul R, Spearing, Paul K, Stanley, Thomas B, Stewart, Eugene L, Willson, Timothy M

“…Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased…”
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Targeting Selective Activation of M1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M1 Positive Allosteric Modulator ML169 by Tarr, James C, Turlington, Mark L, Reid, Paul R, Utley, Thomas J, Sheffler, Douglas J, Cho, Hyekyung P, Klar, Rebecca, Pancani, Tristano, Klein, Michael T, Bridges, Thomas M, Morrison, Ryan D, Blobaum, Anna L, Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M, Conn, P. Jeffrey, Wood, Michael R, Lindsley, Craig W

“…The M1 muscarinic acetylcholine receptor is thought to play an important role in memory and cognition, making it a potential target for the treatment of…”
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Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus by Dutter, Brendan F, Mike, Laura A, Reid, Paul R, Chong, Katherine M, Ramos-Hunter, Susan J, Skaar, Eric P, Sulikowski, Gary A

“…Small molecules active in the pathogenic bacterium Staphylococcus aureus are valuable tools for the study of its basic biology and pathogenesis, and many…”
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Discovery and optimization of a novel, selective and brain penetrant M₁ positive allosteric modulator (PAM): The development of ML169, an MLPCN probe by Reid, Paul R, Bridges, Thomas M, Sheffler, Douglas J, Cho, Hyekyung P, Lewis, L. Michelle, Days, Emily, Daniels, J. Scott, Jones, Carrie K, Niswender, Colleen M, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W, Wood, Michael R

“…This Letter describes a chemical lead optimization campaign directed at VU0108370, a weak M₁ PAM hit with a novel chemical scaffold from a functional HTS…”
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Discovery and optimization of a novel, selective and brain penetrant M 1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe by Reid, Paul R., Bridges, Thomas M., Sheffler, Douglas J., Cho, Hyekyung P., Lewis, L. Michelle, Days, Emily, Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.

“…This Letter describes a chemical lead optimization campaign directed at VU0108370, a weak M 1 PAM hit with a novel chemical scaffold from a functional HTS…”
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Targeting Selective Activation of M 1 for the Treatment of Alzheimer’s Disease: Further Chemical Optimization and Pharmacological Characterization of the M 1 Positive Allosteric Modulator ML169 by Tarr, James C., Turlington, Mark L., Reid, Paul R., Utley, Thomas J., Sheffler, Douglas J., Cho, Hyekyung P., Klar, Rebecca, Pancani, Tristano, Klein, Michael T., Bridges, Thomas M., Morrison, Ryan D., Blobaum, Anna L., Xiang, Zixui, Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Wood, Michael R., Lindsley, Craig W.

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Discovery and optimization of a novel, selective and brain penetrant M sub(1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe) by Reid, Paul R, Bridges, Thomas M, Sheffler, Douglas J, Cho, Hyekyung P, Lewis, LMichelle, Days, Emily, Daniels, JScott, Jones, Carrie K, Niswender, Colleen M, Weaver, CDavid, Conn, PJeffrey, Lindsley, Craig W, Wood, Michael R

“…This Letter describes a chemical lead optimization campaign directed at VU0108370, a weak M sub(1 PAM hit with a novel chemical scaffold from a functional HTS…”
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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169 by Tarr, James C, Turlington, Mark L, Reid, Paul R, Utley, Thomas J, Sheffler, Douglas J, Cho, Hyekyung P, Klar, Rebecca, Pancani, Tristano, Klein, Michael T, Bridges, Thomas M, Morrison, Ryan D, Blobaum, Anna L, Xiang, Zixui, Daniels, J Scott, Niswender, Colleen M, Conn, P Jeffrey, Wood, Michael R, Lindsley, Craig W

“…The M(1) muscarinic acetylcholine receptor is thought to play an important role in memory and cognition, making it a potential target for the treatment of…”
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Need versus demand for orthodontic service by Reid, P R

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