Search Results - "Reid, Molly"
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The contribution of agricultural insecticide use to increasing insecticide resistance in African malaria vectors
Published in Malaria journal (19-02-2016)“…The fight against malaria is increasingly threatened by failures in vector control due to growing insecticide resistance. This review examines the recent…”
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2
Comparison of Blood Counts and Markers of Inflammation and Coagulation in Patients With and Without COVID-19 Presenting to the Emergency Department in Seattle, WA
Published in American journal of clinical pathology (01-08-2021)“…Abstract Objectives We compared complete blood count (CBC) with differential and markers of inflammation and coagulation in patients with and without…”
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3
Evolution of HIV virulence in response to disease-modifying vaccines: A modeling study
Published in Vaccine (13-10-2023)“…Pathogens face a tradeoff with respect to virulence; while more virulent strains often have higher per-contact transmission rates, they are also more likely to…”
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Large benefits to youth-focused HIV treatment-as-prevention efforts in generalized heterosexual populations: An agent-based simulation model
Published in PLoS computational biology (01-12-2019)“…Predominantly heterosexual HIV-1 epidemics like those in sub-Saharan Africa continue to have high HIV incidence in young people. We used a stochastic,…”
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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
Published in PloS one (02-03-2016)“…In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds'…”
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Risk compensation after HIV-1 vaccination may accelerate viral adaptation and reduce cost-effectiveness: a modeling study
Published in Scientific reports (24-03-2021)“…Pathogen populations can evolve in response to selective pressure from vaccine-induced immune responses. For HIV, models predict that viral adaptation, either…”
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A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation
Published in The Journal of infectious diseases (15-01-2014)“…Malaria parasites are transmitted by mosquitoes, and blocking parasite transmission is critical in reducing or eliminating malaria in endemic regions. Here, we…”
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Models to predict the public health impact of vaccine resistance: A systematic review
Published in Vaccine (14-08-2019)“…Pathogen evolution is a potential threat to the long-term benefits provided by public health vaccination campaigns. Mathematical modeling can be a powerful…”
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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors
Published in The Journal of clinical investigation (01-06-2012)“…Effective control and eradication of malaria will require new tools to prevent transmission. Current antimalarial therapies targeting the asexual stage of…”
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10
Examining naloxone access and interest in secondary naloxone distribution on an American Indian Reservation in the Northern Midwest of the United States
Published in Drug and alcohol dependence reports (01-12-2024)“…Indigenous communities in the United States experience disproportionate rates of overdose morbidity and mortality due to a range of historical traumas and…”
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Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity
Published in Journal of medicinal chemistry (08-03-2012)“…Toxoplasmosis is a disease of prominent health concern that is caused by the protozoan parasite Toxoplasma gondii. Proliferation of T. gondii is dependent on…”
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Little cigars and cigarillos harbor diverse bacterial communities that differ between the tobacco and the wrapper
Published in PloS one (22-02-2019)“…Despite their potential importance with regard to infectious and chronic diseases among tobacco users, microbial constituents of tobacco products lack…”
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High levels of interest in access to free safer smoking equipment to reduce injection frequency among people who inject drugs in Seattle, Washington
Published in Drug and alcohol dependence reports (01-06-2023)“…•Seattle-area people who inject drugs were highly interested in free safer smoking equipment for drug consumption.•Despite this interest, and high levels of…”
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14
A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis
Published in The Journal of infectious diseases (15-10-2013)“…Cryptosporidium parasites infect intestinal cells, causing cryptosporidiosis. Despite its high morbidity and association with stunting in the developing world,…”
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15
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes
Published in European journal of medicinal chemistry (03-03-2014)“…Malaria remains a major health concern for a large percentage of the world's population. While great strides have been made in reducing mortality due to…”
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16
Why does age at HIV infection correlate with set point viral load? An evolutionary hypothesis
Published in Epidemics (01-12-2022)“…Set-point viral load (SPVL) correlates with the age at which people acquire HIV. Although immunosenescence may seem like a parsimonious explanation for this,…”
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Mentholation affects the cigarette microbiota by selecting for bacteria resistant to harsh environmental conditions and selecting against potential bacterial pathogens
Published in Microbiome (15-02-2017)“…There is a paucity of data regarding the microbial constituents of tobacco products and their impacts on public health. Moreover, there has been no comparative…”
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Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1
Published in Journal of medicinal chemistry (22-03-2012)“…Diseases caused by the apicomplexan protozoans Toxoplasma gondii and Cryptosporidium parvum are a major health concern. The life cycle of these parasites is…”
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The Bacterial Communities of Little Cigars and Cigarillos Are Dynamic Over Time and Varying Storage Conditions
Published in Frontiers in microbiology (25-10-2019)“…Despite their potential importance with regard to tobacco-related health outcomes, as well as their hypothesized role in the production of tobacco-specific…”
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The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites
Published in Parasitology (01-09-2014)“…Specific roles of individual CDPKs vary, but in general they mediate essential biological functions necessary for parasite survival. A comparative analysis of…”
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