Search Results - "Reid, Hugh H"

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis by Scally, Stephen W, Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L, Nel, Hendrik J, Loh, Khai Lee, Wijeyewickrema, Lakshmi C, Eckle, Sidonia B G, van Heemst, Jurgen, Pike, Robert N, McCluskey, James, Toes, Rene E, La Gruta, Nicole L, Purcell, Anthony W, Reid, Hugh H, Thomas, Ranjeny, Rossjohn, Jamie

“…Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and…”
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The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis by Ting, Yi Tian, Petersen, Jan, Ramarathinam, Sri H., Scally, Stephen W., Loh, Khai L., Thomas, Ranjeny, Suri, Anish, Baker, Daniel G., Purcell, Anthony W., Reid, Hugh H., Rossjohn, Jamie

“…The HLA-DRB1 locus is strongly associated with rheumatoid arthritis (RA) susceptibility, whereupon citrullinated self-peptides bind to HLA-DR molecules bearing…”
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Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease by Mayassi, Toufic, Ladell, Kristin, Gudjonson, Herman, McLaren, James E., Shaw, Dustin G., Tran, Mai T., Rokicka, Jagoda J., Lawrence, Ian, Grenier, Jean-Christophe, van Unen, Vincent, Ciszewski, Cezary, Dimaano, Matthew, Sayegh, Hoda E., Kumar, Vinod, Wijmenga, Cisca, Green, Peter H.R., Gokhale, Ranjana, Jericho, Hilary, Semrad, Carol E., Guandalini, Stefano, Dinner, Aaron R., Kupfer, Sonia S., Reid, Hugh H., Barreiro, Luis B., Rossjohn, Jamie, Price, David A., Jabri, Bana

“…Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic…”
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Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution by Petersen, Jan, Kooy-Winkelaar, Yvonne, Loh, Khai Lee, Tran, Mai, van Bergen, Jeroen, Koning, Frits, Rossjohn, Jamie, Reid, Hugh H.

“…In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the immunodominant DQ8-glia-α1 epitope, whereupon a…”
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The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4 by Loh, Tiing Jen, Lim, Jia Jia, Jones, Claerwen M., Dao, Hien Thy, Tran, Mai T., Baker, Daniel G., La Gruta, Nicole L., Reid, Hugh H., Rossjohn, Jamie

“…CD4 + T cells recognising citrullinated self-epitopes presented by HLA-DRB1 bearing the shared susceptibility epitope (SE) are implicated in rheumatoid…”
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T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8 by Tran, Mai T., Faridi, Pouya, Lim, Jia Jia, Ting, Yi Tian, Onwukwe, Goodluck, Bhattacharjee, Pushpak, Jones, Claerwen M., Tresoldi, Eleonora, Cameron, Fergus J., La Gruta, Nicole L., Purcell, Anthony W., Mannering, Stuart I., Rossjohn, Jamie, Reid, Hugh H.

“…HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced…”
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A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity by Ooi, Joshua D., Jiang, Jhih-Hang, Eggenhuizen, Peter J., Chua, Ling L., van Timmeren, Mirjan, Loh, Khai L., O’Sullivan, Kim M., Gan, Poh Y., Zhong, Yong, Tsyganov, Kirill, Shochet, Lani R., Ryan, Jessica, Stegeman, Coen A., Fugger, Lars, Reid, Hugh H., Rossjohn, Jamie, Heeringa, Peter, Holdsworth, Stephen R., Peleg, Anton Y., Kitching, A. Richard

“…Autoreactivity to myeloperoxidase (MPO) causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), with rapidly progressive…”
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Circulating gluten-specific FOXP3+ CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease by Cook, Laura, PhD, Munier, C. Mee Ling, PhD, Seddiki, Nabila, PhD, van Bockel, David, PhD, Ontiveros, Noé, MSc, Hardy, Melinda Y., PhD, Gillies, Jana K., MSc, Levings, Megan K., PhD, Reid, Hugh H., PhD, Petersen, Jan, PhD, Rossjohn, Jamie, PhD, Anderson, Robert P., PhD, Zaunders, John J., PhD, Tye-Din, Jason A., PhD, Kelleher, Anthony D., PhD

“…Background Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although the effector T-cell response in…”
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The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry by von Büdingen, H-Christian, Mei, Feng, Greenfield, Ariele, Jahn, Sarah, Shen, Yun-An A, Reid, Hugh H, McKemy, David D, Chan, Jonah R

“…Myelin oligodendrocyte glycoprotein (MOG) is a central nervous system myelin-specific molecule expressed on the outer lamellae of myelin. To date, the exact…”
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CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence by Petrie, Emma J, Clements, Craig S, Lin, Jie, Sullivan, Lucy C, Johnson, Darryl, Huyton, Trevor, Heroux, Annie, Hoare, Hilary L, Beddoe, Travis, Reid, Hugh H, Wilce, Matthew C J, Brooks, Andrew G, Rossjohn, Jamie

“…The recognition of human leukocyte antigen (HLA)-E by the heterodimeric CD94-NKG2 natural killer (NK) receptor family is a central innate mechanism by which NK…”
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A Structural and Immunological Basis for the Role of Human Leukocyte Antigen DQ8 in Celiac Disease by Henderson, Kate N., Tye-Din, Jason A., Reid, Hugh H., Chen, Zhenjun, Borg, Natalie A., Beissbarth, Tim, Tatham, Arthur, Mannering, Stuart I., Purcell, Anthony W., Dudek, Nadine L., van Heel, David A., McCluskey, James, Rossjohn, Jamie, Anderson, Robert P.

“…The risk of celiac disease is strongly associated with human leukocyte antigen (HLA) DQ2 and to a lesser extent with HLA DQ8. Although the pathogenesis of…”
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Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis by Sonigra, Amee, Nel, Hendrik J, Wehr, Pascale, Ramnoruth, Nishta, Patel, Swati, van Schie, Karin A, Bladen, Maxwell W, Mehdi, Ahmed M, Tesiram, Joanne, Talekar, Meghna, Rossjohn, Jamie, Reid, Hugh H, Stuurman, Frederik E, Roberts, Helen, Vecchio, Phillip, Gourley, Ian, Rigby, Mark, Becart, Stephane, Toes, Rene Em, Scherer, Hans Ulrich, Lê Cao, Kim-Anh, Campbell, Kim, Thomas, Ranjeny

“…BACKGROUNDAntigen-specific regulation of autoimmune disease is a major goal. In seropositive rheumatoid arthritis (RA), T cell help to autoreactive B cells…”
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Flow Cytometric Clinical Immunomonitoring Using Peptide-MHC Class II Tetramers: Optimization of Methods and Protocol Development by Jansen, Diahann T S L, Ramnoruth, Nishta, Loh, Khai L, Rossjohn, Jamie, Reid, Hugh H, Nel, Hendrik J, Thomas, Ranjeny

“…With the advent of novel strategies to induce tolerance in autoimmune and autoimmune-like conditions, clinical trials of antigen-specific tolerizing…”
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Structural bases of T cell antigen receptor recognition in celiac disease by Ciacchi, Laura, Reid, Hugh H., Rossjohn, Jamie

“…Celiac disease (CeD) is a human leukocyte antigen (HLA)-linked autoimmune-like disorder that is triggered by the ingestion of gluten or related storage…”
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The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition by Sullivan, Lucy C., Clements, Craig S., Beddoe, Travis, Johnson, Darryl, Hoare, Hilary L., Lin, Jie, Huyton, Trevor, Hopkins, Emma J., Reid, Hugh H., Wilce, Matthew C.J., Kabat, Juraj, Borrego, Francisco, Coligan, John E., Rossjohn, Jamie, Brooks, Andrew G.

“…The CD94-NKG2 receptor family that regulates NK and T cells is unique among the lectin-like receptors encoded within the natural killer cell complex. The…”
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Subtle Changes in Peptide Conformation Profoundly Affect Recognition of the Non-Classical MHC Class I Molecule HLA-E by the CD94–NKG2 Natural Killer Cell Receptors by Hoare, Hilary L., Sullivan, Lucy C., Clements, Craig S., Ely, Lauren K., Beddoe, Travis, Henderson, Kate N., Lin, Jie, Reid, Hugh H., Brooks, Andrew G., Rossjohn, Jamie

“…Human leukocyte antigen (HLA)-E is a non-classical major histocompatibility complex class I molecule that binds peptides derived from the leader sequences of…”
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Phosphorylated Self-Peptides Alter Human Leukocyte Antigen Class I-Restricted Antigen Presentation and Generate Tumor-Specific Epitopes by Petersen, Jan, Wurzbacher, Stephanie J., Williamson, Nicholas A., Ramarathinam, H., Reid, Hugh H., Nair, Ashish K. N., Zhao, Anne Y., Nastovska, Roza, Rudge, Geordie, Rossjohn, Jamie, Purcell, Anthony W., Doherty, Peter

“…Human leukocyte antigen (HLA) class I molecules present a variety of posttranslationally modified epitopes at the cell surface, although the consequences of…”
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Identification of Self-antigen–specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis by Law, Soi-Cheng, BSc (Hons), Benham, Helen, B.App.Sci, MBBS (Hons), FRACP, PhD, Reid, Hugh H., BSc (Hons), PhD, Rossjohn, Jamie, BSc (Hons), PhD, Thomas, Ranjeny, MBBS, MD

“…Despite treatment advances, rheumatoid arthritis (RA) is still associated with significant disability, decreased work capacity, and reduced life expectancy…”
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Conveying the pathogenesis of type 1 diabetes to the blind, low‐vision and diverse needs communities through sensory stimulation by Tran, Mai T, Ciacchi, Laura, Ciacchi, Lisa, Reid, Hugh H

“…To educate members of the blind, low‐vision and diverse needs communities on the pathogenesis of the chronic autoimmune disease, type 1 diabetes, members of…”
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A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8 by Tran, Mai T., Lim, Jia Jia, Loh, Tiing Jen, Mannering, Stuart I., Rossjohn, Jamie, Reid, Hugh H.

“…Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that has a strong HLA association, where a number of self-epitopes have been implicated in…”
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