Search Results - "Reichwald, Julia"

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease by Busche, Marc Aurel, Chen, Xiaowei, Henning, Horst A, Reichwald, Julia, Staufenbiel, Matthias, Sakmann, Bert, Konnerth, Arthur

“…Alzheimer’s disease (AD) is characterized by a progressive dysfunction of central neurons. Recent experimental evidence indicates that in the cortex, in…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner by Lenz, Benjamin, Ehrens, Alexandra, Ajendra, Jesuthas, Risch, Frederic, Gal, Joséphine, Neumann, Anna-Lena, Reichwald, Julia J, Strutz, Wiebke, McSorley, Henry J, Martin, Coralie, Hoerauf, Achim, Hübner, Marc P

“…Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the…”
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The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system by Risch, Frederic, Scheunemann, Johanna F, Reichwald, Julia J, Lenz, Benjamin, Ehrens, Alexandra, Gal, Joséphine, Fercoq, Frédéric, Koschel, Marianne, Fendler, Martina, Hoerauf, Achim, Martin, Coralie, Hübner, Marc P

“…Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Oxfendazole (OXF) is one promising macrofilaricidal…”
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ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2 -/- Mice by Reichwald, Julia J, Risch, Frederic, Neumann, Anna-Lena, Frohberger, Stefan J, Scheunemann, Johanna F, Lenz, Benjamin, Ehrens, Alexandra, Strutz, Wiebke, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P

“…Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study,…”
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Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease by Grienberger, Christine, Rochefort, Nathalie L., Adelsberger, Helmuth, Henning, Horst A., Hill, Daniel N., Reichwald, Julia, Staufenbiel, Matthias, Konnerth, Arthur

“…The accumulation of amyloid-β in the brain is an essential feature of Alzheimer's disease. However, the impact of amyloid-β-accumulation on neuronal…”
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Expression of complement system components during aging and amyloid deposition in APP transgenic mice by Reichwald, Julia, Danner, Simone, Wiederhold, Karl-Heinz, Staufenbiel, Matthias

“…A causal role of the complement system in Alzheimer's disease pathogenesis has been postulated based on the identification of different activated components up…”
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Eosinophils Suppress the Migration of T Cells Into the Brain of Plasmodium berghei -Infected Ifnar1 -/- Mice and Protect Them From Experimental Cerebral Malaria by Scheunemann, Johanna F, Reichwald, Julia J, Korir, Patricia Jebett, Kuehlwein, Janina M, Jenster, Lea-Marie, Hammerschmidt-Kamper, Christiane, Lewis, Matthew D, Klocke, Katrin, Borsche, Max, Schwendt, Kim E, Soun, Camille, Thiebes, Stephanie, Limmer, Andreas, Engel, Daniel R, Mueller, Ann-Kristin, Hoerauf, Achim, Hübner, Marc P, Schumak, Beatrix

“…Cerebral malaria is a potentially lethal disease, which is caused by excessive inflammatory responses to parasites. Here we use a newly developed transgenic…”
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Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models by Maia, Luis F, Kaeser, Stephan A, Reichwald, Julia, Lambert, Marius, Obermüller, Ulrike, Schelle, Juliane, Odenthal, Jörg, Martus, Peter, Staufenbiel, Matthias, Jucker, Mathias

“…Abnormalities in brains of Alzheimer's disease (AD) patients are thought to start long before the first clinical symptoms emerge. The identification of…”
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Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis by Scheunemann, Johanna F, Risch, Frederic, Reichwald, Julia J, Lenz, Benjamin, Neumann, Anna-Lena, Garbe, Stephan, Frohberger, Stefan J, Koschel, Marianne, Ajendra, Jesuthas, Rothe, Maximilian, Latz, Eicke, Coch, Christoph, Hartmann, Gunther, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P

“…More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against…”
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Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner by Ehrens, Alexandra, Lenz, Benjamin, Neumann, Anna-Lena, Giarrizzo, Samuela, Reichwald, Julia Jennifer, Frohberger, Stefan Julian, Stamminger, Wiebke, Buerfent, Benedikt Christian, Fercoq, Frédéric, Martin, Coralie, Kulke, Daniel, Hoerauf, Achim, Hübner, Marc Peter

“…Eosinophils mediate protection against filarial nematodes. Our results demonstrate that eosinophil extracellular traps (EETosis) are induced by microfilariae…”
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The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing by Rabe, Sabine, Reichwald, Julia, Ammaturo, Domenico, de Strooper, Bart, Saftig, Paul, Neumann, Ulf, Staufenbiel, Matthias

“…J. Neurochem. (2011) 119, 231–239. Inhibition of β‐secretase (BACE1) is a key therapeutic approach in Alzheimer’s disease (AD), as BACE1 initiates amyloid‐β…”
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Transgenic expression of β1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice by Paganetti, Paolo, Reichwald, Julia, Bleckmann, Dorothee, Abramowski, Dorothee, Ammaturo, Domenico, Barske, Carmen, Danner, Simone, Molinari, Maurizio, Müller, Matthias, Papin, Stéphanie, Rabe, Sabine, Schmid, Peter, Staufenbiel, Matthias

“…Abstract Heterologous expression of the functional amyloid beta (Aβ) antibody β1 in the central nervous system was engineered to maximize antibody exposure in…”
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Hybrid Quantum Machine Learning Assisted Classification of COVID-19 from Computed Tomography Scans by Sunkel, Leo, Martyniuk, Darya, Reichwald, Julia J., Morariu, Andrei, Seggoju, Raja Havish, Altmann, Philipp, Roch, Christoph, Paschke, Adrian

“…Practical quantum computing (QC) is still in its in-fancy and problems considered are usually fairly small, especially in quantum machine learning when…”
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Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein by Maia, Luis F, Kaeser, Stephan A, Reichwald, Julia, Hruscha, Michael, Martus, Peter, Staufenbiel, Matthias, Jucker, Mathias

“…Altered concentrations of amyloid-β (Aβ) peptide and Tau protein in the cerebrospinal fluid (CSF) are thought to be predictive markers for Alzheimer's disease…”
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Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein by Gomes, Luis Aragão, Hipp, Silvia Andrea, Rijal Upadhaya, Ajeet, Balakrishnan, Karthikeyan, Ospitalieri, Simona, Koper, Marta J., Largo-Barrientos, Pablo, Uytterhoeven, Valerie, Reichwald, Julia, Rabe, Sabine, Vandenberghe, Rik, von Arnim, Christine A. F., Tousseyn, Thomas, Feederle, Regina, Giudici, Camilla, Willem, Michael, Staufenbiel, Matthias, Thal, Dietmar Rudolf

“…Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular accumulation of abnormally phosphorylated τ-protein (p-τ) in…”
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The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects by Wiessner, Christoph, Wiederhold, Karl-Heinz, Tissot, Alain C, Frey, Peter, Danner, Simone, Jacobson, Laura H, Jennings, Gary T, Lüönd, Rainer, Ortmann, Rainer, Reichwald, Julia, Zurini, Mauro, Mir, Anis, Bachmann, Martin F, Staufenbiel, Matthias

“…Immunization against amyloid-β (Aβ) can reduce amyloid accumulation in vivo and is considered a potential therapeutic approach for Alzheimer's disease…”
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Alzheimer’s disease‐related necroptotic pathology: An exclusive presence of the necrosome in granulovacuolar degeneration inclusions in human and transgenic mouse brains: Molecular and cell biology/neuronal cell death mechanisms (i.e. apoptosis) by Koper, Marta J., Van Schoor, Evelien, Ospitalieri, Simona, Vandenberghe, Rik, Vandenbulcke, Mathieu, von Arnim, Christine, Tousseyn, Thomas, Reichwald, Julia, Rabe, Sabine, Staufenbiel, Matthias, Balusu, Sriram, De Strooper, Bart, Thal, Dietmar Rudolf

“…Abstract Background Alzheimer’s disease (AD) is characterized by pathological processes such as β‐amyloid (Aβ) plaques, neurofibrillary tangles (NFT),…”
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Alzheimer’s disease‐related necroptotic pathology: An exclusive presence of the necrosome in granulovacuolar degeneration inclusions in human and transgenic mouse brains by Koper, Marta J., Van Schoor, Evelien, Ospitalieri, Simona, Vandenberghe, Rik, Vandenbulcke, Mathieu, von Arnim, Christine, Tousseyn, Thomas, Reichwald, Julia, Rabe, Sabine, Staufenbiel, Matthias, Balusu, Sriram, De Strooper, Bart, Thal, Dietmar Rudolf

“…Background Alzheimer’s disease (AD) is characterized by pathological processes such as β‐amyloid (Aβ) plaques, neurofibrillary tangles (NFT), cytoplasmic…”
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Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode ILitomosoides sigmodontis/I by Scheunemann, Johanna F, Risch, Frederic, Reichwald, Julia J, Lenz, Benjamin, Neumann, Anna-Lena, Garbe, Stephan, Frohberger, Stefan J, Koschel, Marianne, Ajendra, Jesuthas, Rothe, Maximilian, Latz, Eicke, Coch, Christoph, Hartmann, Gunther, Schumak, Beatrix, Hoerauf, Achim, Hübner, Marc P

“…More than two-hundred-million people are infected with filariae worldwide. However, there is no vaccine available that confers long-lasting protection against…”
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