Increased serum cathepsin K in patients with coronary artery disease

Increased serum cathepsin K in patients with coronary artery disease

Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). Between January 2011 and December 2012, 256 consecutive subjects were e...

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Published in:Yonsei medical journal Vol. 55; no. 4; pp. 912 - 919
Main Authors: Li, Xiang, Li, Yuzi, Jin, Jiyong, Jin, Dehao, Cui, Lan, Li, Xiangshan, Rei, Yanna, Jiang, Haiying, Zhao, Guangxian, Yang, Guang, Zhu, Enbo, Nan, Yongshan, Cheng, Xianwu
Format: Journal Article
Language:English
Published: Korea (South) Yonsei University College of Medicine 01-07-2014
연세대학교의과대학
Subjects:
Aged
Biomarkers - blood
C-Reactive Protein - metabolism
Cathepsin K - blood
Coronary Artery Disease - blood
Coronary Artery Disease - metabolism
Female
Humans
Male
Middle Aged
Original
의학일반
coronary artery disease
myocardial ischemia
Cathepsin K
biomarker
high sensitive C-reactive protein
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Summary:Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls. The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8±25.5 ng/mL vs. 86.9±25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1±26.9 ng/mL vs. 102.6±12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01). These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.
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G704-000409.2014.55.4.041
http://www.eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-55-912.pdf
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2014.55.4.912