Search Results - "Reh, Shelley"
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Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses
Published in Proceedings of the National Academy of Sciences - PNAS (19-02-2013)“…DNA polymerase ζ (polζ) is critical for bypass of DNA damage and the associated mutagenesis, but also has unique functions in mammals. It is required for…”
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2
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
Published in PLoS genetics (01-06-2017)“…DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth…”
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3
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs
Published in Nature communications (04-09-2013)“…Mammalian HELQ is a 3′–5′ DNA helicase with strand displacement activity. Here we show that HELQ participates in a pathway of resistance to DNA interstrand…”
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4
Defining the mutation signatures of DNA polymerase θ in cancer genomes
Published in NAR cancer (01-09-2020)“…DNA polymerase theta (POLQ)-mediated end joining (TMEJ) is a distinct pathway for mediating DNA double-strand break (DSB) repair. TMEJ is required for the…”
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Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase ν (POLN)
Published in The Journal of biological chemistry (02-10-2015)“…DNA polymerase ν (POLN) is one of 16 DNA polymerases encoded in vertebrate genomes. It is important to determine its gene expression patterns, biological…”
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Analysis of DNA polymerase [nu] function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
Published in PLoS genetics (01-06-2017)“…DNA polymerase [nu] (pol [nu]), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an…”
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Journal Article -
7
Analysis of DNA polymerase N function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance
Published in PLoS genetics (01-06-2017)“…DNA polymerase N (pol N), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth…”
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Journal Article -
8
Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses
Published in Proceedings of the National Academy of Sciences - PNAS (19-02-2013)Get full text
Journal Article -
9
Dual role for mammalian DNA polymerase [zeta] in maintaining genome stability and proliferative responses
Published in Proceedings of the National Academy of Sciences - PNAS (19-02-2013)“…DNA polymerase ... (pol...) is critical for bypass of DNA damage and the associated mutagenesis, but also has unique functions in mammals. It is required for…”
Get full text
Journal Article -
10
DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentation
Published in Life science alliance (01-06-2018)“…DNA polymerase ζ (pol ζ) is a specialized enzyme important for DNA damage tolerance, facilitating synthesis past lesions caused by radiation or chemical…”
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