Search Results - "Regy, Roshan Mammen"

Improved coarse‐grained model for studying sequence dependent phase separation of disordered proteins by Regy, Roshan Mammen, Thompson, Jacob, Kim, Young C., Mittal, Jeetain

“…We present improvements to the hydropathy scale (HPS) coarse‐grained (CG) model for simulating sequence‐specific behavior of intrinsically disordered proteins…”
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Using a sequence-specific coarse-grained model for studying protein liquid-liquid phase separation by Mammen Regy, Roshan, Zheng, Wenwei, Mittal, Jeetain

“…The formation of membraneless organelles (MLOs) via liquid-liquid phase separation (LLPS) of biomolecules is a topic that has garnered significant attention in…”
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Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations by Regy, Roshan Mammen, Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Mittal, Jeetain

“…Abstract Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via…”
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Living cells as test tubes by Mammen Regy, Roshan, Mittal, Jeetain

“…Thermodynamic principles are used to map the phase behavior of a tunable protein-binding system under crowded cellular conditions. This study marks a…”
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Reversible Kinetic Trapping of FUS Biomolecular Condensates by Chatterjee, Sayantan, Kan, Yelena, Brzezinski, Mateusz, Koynov, Kaloian, Regy, Roshan Mammen, Murthy, Anastasia C., Burke, Kathleen A., Michels, Jasper J., Mittal, Jeetain, Fawzi, Nicolas L., Parekh, Sapun H.

“…Formation of membrane‐less organelles by self‐assembly of disordered proteins can be triggered by external stimuli such as pH, salt, or temperature. These…”
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Amphiphilic proteins coassemble into multiphasic condensates and act as biomolecular surfactants by Kelley, Fleurie M., Favetta, Bruna, Regy, Roshan Mammen, Mittal, Jeetain, Schuster, Benjamin S.

“…Cells contain membraneless compartments that assemble due to liquid–liquid phase separation, including biomolecular condensates with complex morphologies. For…”
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Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior by Schuster, Benjamin S., Dignon, Gregory L., Tang, Wai Shing, Kelley, Fleurie M., Ranganath, Aishwarya Kanchi, Jahnke, Craig N., Simpkins, Alison G., Regy, Roshan Mammen, Hammer, Daniel A., Good, Matthew C., Mittal, Jeetain

“…Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the formation of membraneless organelles, which compartmentalize molecules…”
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Biomolecular Condensates: Sequence Determinants of Phase Separation, Microstructural Organization, Enzymatic Activity, and Material Properties by Schuster, Benjamin S, Regy, Roshan Mammen, Dolan, Elliott M, Kanchi Ranganath, Aishwarya, Jovic, Nina, Khare, Sagar D, Shi, Zheng, Mittal, Jeetain

“…This perspective article highlights recent progress and emerging challenges in understanding the formation and function of membraneless organelles (MLOs). A…”
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Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior by Schuster, Benjamin S., Dignon, Gregory L., Tang, Wai Shing, Kelley, Fleurie M., Ranganath, Aishwarya Kanchi, Jahnke, Craig N., Simpkins, Alison G., Regy, Roshan Mammen, Hammer, Daniel A., Good, Matthew C., Mittal, Jeetain

“…Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the formation of membraneless organelles, which compartmentalize molecules…”
Get full text