Search Results - "Regouski, Misha"

Efficient gene knockout in goats using CRISPR/Cas9 system by Ni, Wei, Qiao, Jun, Hu, Shengwei, Zhao, Xinxia, Regouski, Misha, Yang, Min, Polejaeva, Irina A, Chen, Chuangfu

“…The CRISPR/Cas9 system has been adapted as an efficient genome editing tool in laboratory animals such as mice, rats, zebrafish and pigs. Here, we report that…”
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Contribution of atrial myofiber architecture to atrial fibrillation by Kamali, Roya, Kwan, Eugene, Regouski, Misha, Bunch, T Jared, Dosdall, Derek J, Hsu, Ed, Macleod, Rob S, Polejaeva, Irina, Ranjan, Ravi

“…The role of fiber orientation on a global chamber level in sustaining atrial fibrillation (AF) is unknown. The goal of this study was to correlate the fiber…”
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A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene by Fan, Zhiqiang, Perisse, Iuri Viotti, Cotton, Calvin U, Regouski, Misha, Meng, Qinggang, Domb, Chaim, Van Wettere, Arnaud J, Wang, Zhongde, Harris, Ann, White, Kenneth L, Polejaeva, Irina A

“…Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The major cause of limited life span…”
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Stellate cells are in utero markers of pancreatic disease in cystic fibrosis by Leir, Shih-Hsing, Tkachenko, Svyatoslav, Paranjapye, Alekh, Meckler, Frederick, Van Wettere, Arnaud J, Kerschner, Jenny L, Kuznetsov, Elizabeth, Schacht, Makayla, Gillurkar, Pulak, Regouski, Misha, Viotti Perisse, Iuri, Marriott, Cheyenne M, Liu, Ying, Bunderson, Ian, White, Kenneth L, Polejaeva, Irina A, Harris, Ann

“…Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic…”
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Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system by Wu, Hua, Fan, Zhiqiang, Brandsrud, Michelle, Meng, Qinggang, Bobbitt, Molly, Regouski, Misha, Stott, Rusty, Sweat, Alexis, Crabtree, Jackelyn, Hogan, Robert J., Tripp, Ralph A., Wang, Zhongde, Polejaeva, Irina A., Sullivan, Eddie J.

“…To address the unmet needs for human polyclonal antibodies both as therapeutics and diagnostic reagents, building upon our previously established…”
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Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling by Davies, Christopher J., Fan, Zhiqiang, Morgado, Kira P., Liu, Ying, Regouski, Misha, Meng, Qinggang, Thomas, Aaron J., Yun, Sang-Im, Song, Byung-Hak, Frank, Jordan C., Perisse, Iuri V., Van Wettere, Arnaud, Lee, Young-Min, Polejaeva, Irina A.

“…Type I interferons (IFNs) initiate immune responses to viral infections. Their effects are mediated by the type I IFN receptor, IFNAR, comprised of two…”
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Early developmental phenotypes in the cystic fibrosis sheep model by Van Wettere, Arnaud J., Leir, Shih‐Hsing, Cotton, Calvin U., Regouski, Misha, Viotti Perisse, Iuri, Kerschner, Jenny L., Paranjapye, Alekh, Fan, Zhiqiang, Liu, Ying, Schacht, Makayla, White, Kenneth L., Polejaeva, Irina A., Harris, Ann

“…Highly effective modulator therapies for cystic fibrosis (CF) make it a treatable condition for many people. However, although CF respiratory illness occurs…”
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Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics by Viotti Perisse, Iuri, Fan, Zhiqiang, Van Wettere, Arnaud, Liu, Ying, Leir, Shih‐Hsing, Keim, Jacob, Regouski, Misha, Wilson, Michael D., Cholewa, Kelly M., Mansbach, Sara N., Kelley, Thomas J., Wang, Zhongde, Harris, Ann, White, Kenneth L., Polejaeva, Irina A.

“…Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. The F508del and G542X are the most…”
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MP-453085-7 PROGESTERONE WITHDRAWAL ASSOCIATED WITH INCREASED ATRIAL FIBRILLATION SUSCEPTIBILITY IN FEMALES by Regouski, Misha, Liu, Ying, Rutigliano, Heloisa, Polejaeva, Irina, Cutler, Michael J.

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301.4: Gal knockout sheep: a new paradigm for future preclinical biological heart valve testing by McGregor, Christopher GA, Byrne, Guerard W, Fan, Zhiqiang, Liu, Ying, Regouski, Misha, Polejaeva, Irina A

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Abstract 4136863: Diffuse Functional and Structural Abnormalities in Fibrosis: Potential Structural Basis for Sustaining Atrial Fibrillation by Kwan, Eugene, ghafoori, elyar, Good, Wilson, Regouski, Misha, Moon, Boyce, Fish, Jeffrey, Hsu, Edward, Polejaeva, Irina, MacLeod, Rob, Dosdall, Derek, Ranjan, Ravi

“…Abstract only Background: Structural remodeling is associated with atrial fibrillation (AF), but detailed structural and functional characteristics is not well…”
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Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males by Ciccarelli, Michela, Giassetti, Mariana I., Miao, Deqiang, Oatley, Melissa J., Robbins, Colton, Lopez-Biladeau, Blanca, Waqas, Muhammad Salman, Tibary, Ahmed, Whitelaw, Bruce, Lillico, Simon, Park, Chi-Hun, Park, Ki-Eun, Telugu, Bhanu, Fan, Zhiqiang, Liu, Ying, Regouski, Misha, Polejaeva, Irina A., Oatley, Jon M.

“…Spermatogonial stem cell transplantation (SSCT) is an experimental technique for transfer of germline between donor and recipient males that could be used as a…”
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A retrospective analysis of sheep generated by somatic cell nuclear transfer by Liu, Ying, Stott, Rusty, Regouski, Misha, Fan, Zhiqiang, Perisse, Iuri Viotti, Patrick, Tayler, Keim, Jacob, Meng, Qinggang, Polejaeva, Irina A.

“…Somatic cell nuclear transfer (SCNT) is one of the primary methods for production of genetically engineered sheep, which allows for gene editing or transgene…”
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Diffuse functional and structural abnormalities in fibrosis: Potential structural basis for sustaining atrial fibrillation by Kwan, Eugene, Ghafoori, Elyar, Good, Wilson, Regouski, Misha, Moon, Boyce, Fish, Jeffrey M., Hsu, Edward, Polejaeva, Irina A., MacLeod, Rob S., Dosdall, Derek J., Ranjan, Ravi

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Novel Sheep Model of Sickle Cell Disease Reproduces Human Clinical and Laboratory Parameters by Kuczynski, Caroline E., Perisse, Iuri V., Regouski, Misha, Alipour, Elmira, LaPradd, Cecily, Liu, Ying, Beaty, Michael W., Kim-Shapiro, Daniel B., Atala, Anthony, Polejaeva, Irina, Porada, Christopher D., Almeida-Porada, M. Graca

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Gene Knockouts in Goats Using CRISPR/Cas9 System and Somatic Cell Nuclear Transfer by Fan, Zhiqiang, Yang, Min, Regouski, Misha, Polejaeva, Irina A

“…The combination of CRISPR/Cas9 and SCNT techniques greatly facilitates the production of gene-edited livestock. Here, we describe the detailed procedure to…”
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Assessment of microchimerism following somatic cell nuclear transfer and natural pregnancies in goats by Gash, Kirsten K, Yang, Min, Fan, Zhiqiang, Regouski, Misha, Rutigliano, Heloisa M, Polejaeva, Irina A

“…Abstract Microchimerism is defined as the presence of a small population of cells or DNA in 1 organism originated from a genetically different organism. It is…”
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Effects of three different media on in vitro maturation and development, intracellular glutathione and reactive oxygen species levels, and maternal gene expression of abattoir-derived goat oocytes by Fan, Zhiqiang, Yang, Min, Regouski, Misha, Polejaeva, Irina A.

“…•The effect of three maturation media has been evaluated on the in vitro maturation and developmental competence of abattoir-derived goat oocytes.•The…”
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Oocytes from small and large follicles exhibit similar development competence following goat cloning despite their differences in meiotic and cytoplasmic maturation by Yang, Min, Hall, Justin, Fan, Zhiqiang, Regouski, Misha, Meng, Qinggang, Rutigliano, Heloisa M., Stott, Rusty, Rood, Kerry A., Panter, Kip E., Polejaeva, Irina A.

“…Reduced developmental competence after IVF has been reported using oocyte derived from small follicles in several species including cattle, sheep, and goats…”
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Transcriptomic analysis of lung development in wildtype and CFTR−/− sheep suggests an early inflammatory signature in the CF distal lung by Kerschner, Jenny L., Paranjapye, Alekh, Schacht, Makayla, Meckler, Frederick, Huang, Felix, Bebek, Gurkan, Van Wettere, Arnaud J., Regouski, Misha, Perisse, Iuri Viotti, White, Kenneth L., Polejaeva, Irina A., Leir, Shih-Hsing, Harris, Ann

“…The precise molecular events initiating human lung disease are often poorly characterized. Investigating prenatal events that may underlie lung disease in…”
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