Adhesive Bioactive Coatings Inspired by Sea Life

Adhesive Bioactive Coatings Inspired by Sea Life

Inspired by nature, in particular by the marine mussels adhesive proteins (MAPs) and by the tough brick-and-mortar nacre-like structure, novel multilayered films are prepared in the present work. Organic–inorganic multilayered films, with an architecture similar to nacre based on bioactive glass nan...

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Bibliographic Details
Published in:Langmuir Vol. 32; no. 2; pp. 560 - 568
Main Authors: Rego, Sónia J, Vale, Ana C, Luz, Gisela M, Mano, João F, Alves, Natália M
Format: Journal Article
Language:English
Published: United States American Chemical Society 19-01-2016
Subjects:
Adhesiveness
Adhesives - chemistry
Animals
Aquatic Organisms
Biomimetic Materials - chemistry
Bivalvia - chemistry
Bivalvia - physiology
Chitosan - chemistry
Coated Materials, Biocompatible - chemistry
Glass - chemistry
Hyaluronic Acid - chemistry
Microscopy, Atomic Force
Nacre - chemistry
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Proteins - chemistry
Proteins - secretion
Quartz Crystal Microbalance Techniques
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Summary:Inspired by nature, in particular by the marine mussels adhesive proteins (MAPs) and by the tough brick-and-mortar nacre-like structure, novel multilayered films are prepared in the present work. Organic–inorganic multilayered films, with an architecture similar to nacre based on bioactive glass nanoparticles (BG), chitosan, and hyaluronic acid modified with catechol groups, which are the main components responsible for the outstanding adhesion in MAPs, are developed for the first time. The biomimetic conjugate is prepared by carbodiimide chemistry and analyzed by ultraviolet–visible spectrophotometry. The buildup of the multilayered films is monitored with a quartz crystal microbalance with dissipation monitoring, and their topography is characterized by atomic force microscopy. The mechanical properties reveal that the films containing catechol groups and BG present an enhanced adhesion. Moreover, the bioactivity of the films upon immersion in a simulated body fluid solution is evaluated by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. It was found that the constructed films promote the formation of bonelike apatite in vitro. Such multifunctional mussel inspired LbL films, which combine enhanced adhesion and bioactivity, could be potentially used as coatings of a variety of implants for orthopedic applications.
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ISSN:0743-7463
1520-5827
DOI:10.1021/acs.langmuir.5b03508