Search Results - "Rego, E. M."

Synthetic phosphoethanolamine has in vitro and in vivo anti-leukemia effects by Ferreira, A K, Santana-Lemos, B A A, Rego, E M, Filho, O M R, Chierice, G O, Maria, D A

“…Background: We recently showed that synthetic phosphoethanolamine reduces tumour growth and inhibits lung metastasis in vivo . Here, we investigated its…”
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Leukemia with distinct phenotypes in transgenic mice expressing PML/RARα, PLZF/RARα or NPM/RARα by REGO, E. M, RUGGERO, D, TRIBIOLI, C, CATTORETTI, G, KOGAN, S, REDNER, R. L, PANDOLFI, P. P

“…Recurrent chromosomal translocations involving the RAR alpha locus on chromosome 17 are the hallmark of acute promyelocytic leukemia (APL). The RAR alpha gene…”
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CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice by Lange, A P, Almeida, L Y, Araújo Silva, C L, Scheucher, P S, Chahud, F, Krause, A, Bohlander, S K, Rego, E M

“…Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed…”
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FLORENCE: a randomized, double-blind, phase III pivotal study of febuxostat versus allopurinol for the prevention of tumor lysis syndrome (TLS) in patients with hematologic malignancies at intermediate to high TLS risk by Spina, M., Nagy, Z., Ribera, J.M., Federico, M., Aurer, I., Jordan, K., Borsaru, G., Pristupa, A.S., Bosi, A., Grosicki, S., Glushko, N.L., Ristic, D., Jakucs, J., Montesinos, P., Mayer, J., Rego, E.M., Baldini, S., Scartoni, S., Capriati, A., Maggi, C.A., Simonelli, C.

“…Serum uric acid (sUA) control is of key relevance in tumor lysis syndrome (TLS) prevention as it correlates with both TLS and renal event risk. We sought to…”
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(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo by dos Santos, G A S, Abreu e Lima, R S, Pestana, C R, Lima, A S G, Scheucher, P S, Thomé, C H, Gimenes-Teixeira, H L, Santana-Lemos, B A A, Lucena-Araujo, A R, Rodrigues, F P, Nasr, R, Uyemura, S A, Falcão, R P, de Thé, H, Pandolfi, P P, Curti, C, Rego, E M

“…The vitamin E derivative (+)α-tocopheryl succinate (α-TOS) exerts pro-apoptotic effects in a wide range of tumors and is well tolerated by normal tissues…”
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P440: THE COMBINATION VENETOCLAX PLUS MCL1 OVERCOMES DRUG RESISTANCE IN ACUTE PROMYELOCYTIC LEUKEMIA by Pereira-Martins, D. A., Noguera, N. I., Ottone, T., Diepstra, A., Ortiz, C., Weinhauser, I., Huls, G., Schuringa, J. J., Rego, E. M., Ammatuna, E.

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Disrupting membrane raft domains by alkylphospholipids by Gomide, A.B., Thomé, C.H., dos Santos, G.A., Ferreira, G.A., Faça, V.M., Rego, E.M., Greene, L.J., Stabeli, R.G., Ciancaglini, P., Itri, R.

“…Using phase contrast and fluorescence microscopy we study the influence of the alkylphospholipid, ALP, 10-(octyloxy) decyl-2-(trimethylammonium) ethyl…”
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Biological X-ray irradiator characterization for use with small animals and cells by Bruno, A Colello, Mazaro, S J, Amaral, L L, Rego, E M, Oliveira, H F, Pavoni, J F

“…This study presents the characterization of an X-ray irradiator through dosimetric tests, which confirms the actual dose rate that small animals and cells will…”
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Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A by Furtado, F M, Scheucher, P S, Santana, B A, Scatena, N F, Calado, R T, Rego, E M, Matos, D M, Falcão, R P

“…Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic clinical entity characterized by the proliferation of monoclonal B cells not meeting the diagnosis…”
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P439: ASSOCIATING EX VIVO DRUG SENSITIVITY WITH METABOLIC STATUS IDENTIFIES EFFECTIVE COMBINATION STRATEGIES IN ACUTE MYELOID LEUKEMIA by Pereira‐Martins, D. A., Griessinger, E., Weinhauser, I., Coelho‐Silva, J. L., Silveira, D. R., Quek, L., Erdem, A., Hilberink, J. R., Paula, E. V., Olalla Saad, S. T., Ammatuna, E., Huls, G., Rego, E. M., Lucena‐Araujo, A. R., Schuringa, J. J.

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S252: M2‐POLARIZED MACROPHAGES CONTROL LEUKEMIC STEM CELL FATE BY PROMOTING METABOLIC REPROGRAMMING by Weinhäuser, I., Pereira‐Martins, D. A., Hilberink, J. R., Almeida, L. Y., Silveira, D. R. A., Quek, L., Hogeling, S. M, Mota, J. M., Ammatuna, E., Lucena‐Araujo, A. R., Huls, G. A., Rego, E. M., Schuringa, J. J.

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P396: DYSREGULATED DNAM‐1 AND KIR2DL1 EXPRESSION IN NATURAL KILLER CELLS CORRELATES WITH POOR OUTCOME IN ACUTE MYELOID LEUKEMIA by F O Costa, A., O Marani, L., A Lopes, I., S Binelli, L., S Scheucher, P., L S Schiavinato, J., A Madeira, M. I., B B Pagnano, K., K Duarte, B., F Glória, A. B., M Rego, E., Traina, F., Welner, R., L Figueiredo‐Pontes, L.

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PB1814: RARE PHENOTYPE WITH CD33 ABSENT IN ACUTE MYELOID LEUKEMIA MIMICKING MRD POSITIVITY: A CASE REPORT by O Marani, L., Costa, A., B Silva, F., A Madeira, M. I., S Scheucher, P., L S Schiavinato, J., G Lima, A. S., B B Pagnano, K., K Duarte, B., Freeman, S., M Rego, E., Traina, F., L Figueiredo‐Pontes, L.

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YM115, A PHARMACOLOGICAL SUPPRESSANT OF SURVIVIN/XIAP, EXHIBITS ANTINEOPLASTIC ACTIVITY IN JAK2V617F CELLS by JAEG Carlos, K Lima, EM Rego, LV Cost-Lotufo, JA Machad-Neto

“…Objective: The central role of the control of apoptosis in the pathophysiology of Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) has been…”
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CHRONIC LYMPHOCYTIC LEUKEMIA WITH PERICARDIAL INFILTRATION: A CASE REPORT by RDF Farias, MRF Dória, L Nardinelli, WF Silva, EDPR Velloso, RCB Melo, CA Silva, EM Rego, V Rocha, V Buccheri

“…Introduction: Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults. It commonly has an indolent course and can infiltrate any organ…”
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RENAL INVOLVEMENT IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: A CASE SERIES by JCK Dos-Santos, MW Araujo, EC Costalong, RCB Melo, VTCE Silv, WF Silva, EM Rego, V Rocha, V Buccheri

“…Introduction: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. It can infiltrate any organ, most commonly lymph nodes. When renal…”
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HIGH LEUKEMIC STEM CELL FREQUENCY IN FLT3- MUTATED ACUTE MYELOID LEUKEMIA PATIENTS WITH NORMAL KARYOTYPE: IMPLICATIONS FOR PROGNOSIS by CAB Garcia, LO Marani, M Medeiros, MIA Madeira, K Pagnano, E Nunes, ABF Glória, EM Rego, AG Carvalho, F Traina, LL Figueiredo-Pontes

“…Normal karyotype in Acute Myeloid Leukemia (NK-AML) occurs in 40-50% of patients. Leukemic Stem Cells (LSC) persistence is known to trigger relapse, but the…”
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CHALLENGES IN PREDICTING THROMBOEMBOLIC RISK IN ACUTE LEUKEMIA: CLINICAL PROFILING AND LIMITATIONS OF CURRENT SCORING SYSTEMS by LV Carvalho, JVR Oliveira, RCB Melo, FR Mendes, C Rothschild, EDRP Velloso, V Rocha, EM Rego, FA Orsi, WF Silva

“…Introduction: Patients with newly diagnosed Acute Leukemia (AL) are prone to an increased risk of thrombosis through mechanisms not completely understood. The…”
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35 years of the Brazilian Journal of Medical and Biological Research by Rego, E M, Pereira Leite, J, Bensenor, I, Chammas, R, Nogueira de Francischi, J, da Luz, P L

“…The authors pay homage to the three founders of the Brazilian Journal of Medical and Biological Research Profs. Lewis Joel Greene, Sérgio Henrique Ferreira and…”
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COMPARISON OF EARLY MORTALITY BETWEEN ACUTE MYELOID LEUCEMIA PATIENTS TREATED IN PUBLIC OR PRIVATE CENTERS: ANALYSIS FROM THE BRAZILIAN ACUTE MYELOID LEUKEMIA REGISTRY by LL Perruso, A Costa, WF Silva, FR Mendes, V Pfister, RS Siquieroli, J Martins, C Chiattone, M Nascimento, ER Mattos, MDH Perico, YS Rabelo, EM Rego

“…The Brazilian Acute Myeloid Leukemia Registry (RBLMA) is a recent initiative aimed at determining the clinical and epidemiological aspects of acute myeloid…”
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