Search Results - "Regna, Nicole L"

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus by Shimp, Samuel K, Chafin, Cristen B, Regna, Nicole L, Hammond, Sarah E, Read, Molly A, Caudell, David L, Rylander, MarissaNichole, Reilly, Christopher M

“…Elevated expression of heat shock protein 90 (HSP90) has been found in kidneys and serum of systemic lupus erythematosus (SLE) patients and MRL/Mp- Fas lpr /…”
Get full text

Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo by Regna, Nicole L, Chafin, Cristen B, Hammond, Sarah E, Puthiyaveetil, Abdul G, Caudell, David L, Reilly, Christopher M

“…Abstract We sought to determine if a specific class I and II HDAC inhibitor (ITF2357) was able to decrease disease in lupus-prone NZB/W mice through regulation…”
Get full text

Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice by Regna, Nicole L, Vieson, Miranda D, Luo, Xin M, Chafin, Cristen B, Puthiyaveetil, Abdul Gafoor, Hammond, Sarah E, Caudell, David L, Jarpe, Matthew B, Reilly, Christopher M

“…Abstract We sought to determine if a selective HDAC6 inhibitor (ACY-738) decreases disease in NZB/W mice. From 22 to 38 weeks-of-age, mice were injected…”
Get full text

HDAC expression and activity is upregulated in diseased lupus-prone mice by Regna, Nicole L., Vieson, Miranda D., Gojmerac, Alexander M., Luo, Xin M., Caudell, David L., Reilly, Christopher M.

“…Prior studies have shown that pan-HDAC inhibition can decrease disease in lupus mice; however, the mechanisms(s) remain to be elucidated. MRL/MpJ-Faslpr…”
Get full text

Cellular and urinary microRNA alterations in NZB/W mice with hydroxychloroquine or prednisone treatment by Chafin, Cristen B., Regna, Nicole L., Hammond, Sarah E., Reilly, Christopher M.

“…Determining alterations to disease-associated miRNAs induced by specific therapeutics may allow the use of tailored therapy in lupus. We determined miRNA…”
Get full text

MicroRNA-let-7a expression is increased in the mesangial cells of NZB/W mice and increases IL-6 production in vitro by Chafin, Cristen B., Regna, Nicole L., Dai, Rujuan, Caudell, David L., Reilly, Christopher M.

“…Abstract Recent evidence supports a role for epigenetic alterations in the pathogenesis of systemic lupus erythematosus (SLE). MicroRNAs (miRNAs or miRs) are…”
Get full text

MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFκB activation in vitro by Chafin, Cristen B, Regna, Nicole L, Caudell, David L, Reilly, Christopher M

“…Epigenetic factors, including altered microRNA (miRNA) expression, may contribute to aberrant immune cell function in systemic lupus erythematosus (SLE)…”
Get full text

HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways by Shimp, Samuel K., Parson, Carl D., Regna, Nicole L., Thomas, Alicia N., Chafin, Cristen B., Reilly, Christopher M., Nichole Rylander, M.

“…Objective This study was designed to determine whether inhibition of heat shock protein 90 (HSP90) reduces pro-inflammatory mediator production by decreasing…”
Get full text

MicroRNA-let-7a promotes E2F-mediated cell proliferation and NF[kappa]B activation in vitro by Chafin, Cristen B, Regna, Nicole L, Caudell, David L, Reilly, Christopher M

“…Epigenetic factors, including altered microRNA (miRNA) expression, may contribute to aberrant immune cell function in systemic lupus erythematosus (SLE)…”
Get full text

MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFKB activation in vitro by Cristen B Chafin Nicole L Regna David L Caudell Christopher M Reilly

“…Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）…”
Get full text

HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-[kappa]B pathways by Shimp, Samuel K, Parson, Carl D, Regna, Nicole L, Thomas, Alicia N, Chafin, Cristen B, Reilly, Christopher M, Nichole Rylander, M

“…This study was designed to determine whether inhibition of heat shock protein 90 (HSP90) reduces pro-inflammatory mediator production by decreasing the nuclear…”
Get full text

Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis by Regna, Nicole L

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease requiring a genetic predisposition coupled with an environmental trigger in order for…”
Get full text

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus by Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly

“…Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and…”
Get full text