Search Results - "Regina Souza Lima, Flavia"

Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies by Geraldo, Luiz Henrique Medeiros, Spohr, Tânia Cristina Leite de Sampaio, Amaral, Rackele Ferreira do, Fonseca, Anna Carolina Carvalho da, Garcia, Celina, Mendes, Fabio de Almeida, Freitas, Catarina, dosSantos, Marcos Fabio, Lima, Flavia Regina Souza

“…Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review…”
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The impact of microglial activation on blood-brain barrier in brain diseases by da Fonseca, Anna Carolina Carvalho, Matias, Diana, Garcia, Celina, Amaral, Rackele, Geraldo, Luiz Henrique, Freitas, Catarina, Lima, Flavia Regina Souza

“…The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs) together with neurons and glial cells, including microglia, forms…”
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and glial cells: Insights and perspectives by Vargas, Gabriele, Medeiros Geraldo, Luiz Henrique, Gedeão Salomão, Natália, Viana Paes, Marciano, Regina Souza Lima, Flavia, Carvalho Alcantara Gomes, Flávia

“…In December 2019, a pneumonia outbreak was reported in Wuhan, Hubei province, China. Since then, the World Health Organization declared a public health…”
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The reciprocal interactions between astrocytes and prostate cancer cells represent an early event associated with brain metastasis by de Oliveira Barros, Eliane Gouvêa, Palumbo, Antonio, Mello, Pedro Lucas Prado, de Mattos, Rômulo Medina, da Silva, Julianna Henriques, Pontes, Bruno, Viana, Nathan Bessa, do Amaral, Rackele Ferreira, Lima, Flavia Regina Souza, da Costa, Nathalia Meireles, Palmero, Celia Yelimar, Miranda-Alves, Leandro, Takiya, Christina Maeda, Nasciutti, Luiz Eurico

“…Tumor establishment, growth, and survival are supported by interactions with microenvironment components. Here, we investigated whether the interactions…”
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The multiple functions of PrPC in physiological, cancer, and neurodegenerative contexts by Grimaldi, Izabella, Leser, Felipe Saceanu, Janeiro, José Marcos, da Rosa, Bárbara Gomes, Campanelli, Ana Clara, Romão, Luciana, Lima, Flavia Regina Souza

“…Cellular prion protein (PrP C ) is a highly conserved glycoprotein, present both anchored in the cell membrane and soluble in the extracellular medium. It has…”
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Lack of galectin-3 speeds Wallerian degeneration by altering TLR and pro-inflammatory cytokine expressions in injured sciatic nerve by Mietto, Bruno Siqueira, Jurgensen, Sofia, Alves, Lucinéia, Pecli, Cyntia, Narciso, Marcelo Sampaio, Assunção-Miranda, Iranaia, Villa-Verde, Dea Maria Serra, de Souza Lima, Flávia Regina, de Menezes, João Ricardo Lacerda, Benjamim, Cláudia Farias, Bozza, Marcelo Torres, Martinez, Ana Maria Blanco

“…Wallerian degeneration (WD) comprises a series of events that includes activation of non‐neuronal cells and recruitment of immune cells, creating an…”
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Glioblastoma cells: A heterogeneous and fatal tumor interacting with the parenchyma by Alves, Tercia Rodrigues, Lima, Flavia Regina Souza, Kahn, Suzana Assad, Lobo, Denise, Dubois, Luiz Gustavo Feijó, Soletti, Rossana, Borges, Helena, Neto, Vivaldo Moura

“…Glioblastomas (GBMs) are considered to be one of the deadliest human cancers, characterized by a high proliferative rate, aggressive invasiveness and…”
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High levels of Cellular Prion Protein improve astrocyte development by Hartmann, Camila Arantes, Martins, Vilma Regina, Lima, Flavia Regina Souza

“…► PrPC over-expression promotes resistance to death and early maturation of astrocytes. ► PrPC interacts with STI1 and induces astrocyte survival through the…”
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Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis by Moraes, Carolina A., Santos, Gabriel, Spohr, Tania Cristina Leite de Sampaio e, D’Avila, Joana C., Lima, Flávia Regina Souza, Benjamim, Claudia Farias, Bozza, Fernando A., Gomes, Flávia Carvalho Alcantara

“…Recent clinical studies have shown that sepsis survivors may develop long-term cognitive impairments. The cellular and molecular mechanisms involved in these…”
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The multiple functions of the co-chaperone stress inducible protein 1 by da Fonseca, Anna Carolina Carvalho, Matias, Diana, Geraldo, Luiz Henrique Medeiros, Leser, Felipe Saceanu, Pagnoncelli, Iohana, Garcia, Celina, do Amaral, Rackele Ferreira, da Rosa, Barbara Gomes, Grimaldi, Izabella, de Camargo Magalhães, Eduardo Sabino, Cóppola-Segovia, Valentín, de Azevedo, Evellyn Mayla, Zanata, Silvio Marques, Lima, Flavia Regina Souza

“…[Display omitted] •STI1 is a co-chaperone involved in the correct client proteins' folding.•Extracellular STI1 is crucial for CNS maintenance and…”
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GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling by Matias, Diana, Dubois, Luiz Gustavo, Pontes, Bruno, Rosário, Luciane, Ferrer, Valeria Pereira, Balça-Silva, Joana, Fonseca, Anna Carolina Carvalho, Macharia, Lucy Wanjiku, Romão, Luciana, e Spohr, Tania Cristina Leite de Sampaio, Chimelli, Leila, Filho, Paulo Niemeyer, Lopes, Maria Celeste, Abreu, José Garcia, Lima, Flavia Regina Souza, Moura-Neto, Vivaldo

“…Glioblastoma is an extremely aggressive and deadly brain tumor known for its striking cellular heterogeneity and capability to communicate with…”
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Perinatal Asphyxia and Brain Development: Mitochondrial Damage Without Anatomical or Cellular Losses by Lima, Jean Pierre Mendes, Rayêe, Danielle, Silva-Rodrigues, Thaia, Pereira, Paula Ribeiro Paes, Mendonca, Ana Paula Miranda, Rodrigues-Ferreira, Clara, Szczupak, Diego, Fonseca, Anna, Oliveira, Marcus F., Lima, Flavia Regina Souza, Lent, Roberto, Galina, Antonio, Uziel, Daniela

“…Perinatal asphyxia remains a significant cause of neonatal mortality and is associated with long-term neurodegenerative disorders. In the present study, we…”
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Identity of the cells recruited to a lesion in the central nervous system of a decapod crustacean by Chaves-da-Silva, Paula Grazielle, de Barros, Cintia Monteiro, Lima, Flávia Regina Souza, Biancalana, Adriano, Martinez, Ana Maria Blanco, Allodi, Silvana

“…In a previous study, we analyzed and described the features of the degeneration of the protocerebral tract (PCT) of the crustacean Ucides cordatus, after the…”
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Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response by Garcia, Carlos Gustavo, Kahn, Suzana Assad, Geraldo, Luiz Henrique Medeiros, Romano, Igor, Domith, Ivan, Silva, Deborah Christinne Lima e, dos Santos Assunção, Fernando, Ferreira, Marcos José, Portugal, Camila Cabral, de Souza, Jorge Marcondes, Romão, Luciana Ferreira, Netto, Annibal Duarte Pereira, Lima, Flávia Regina Souza, Cossenza, Marcelo

“…Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor and still lacks effective therapeutic strategies. It has already been shown…”
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The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model by Garcia, Celina, Dubois, Luiz Gustavo, Xavier, Anna Lenice, Geraldo, Luiz Henrique, da Fonseca, Anna Carolina Carvalho, Correia, Ana Helena, Meirelles, Fernanda, Ventura, Grasiella, Romão, Luciana, Canedo, Nathalie Henriques Silva, de Souza, Jorge Marcondes, de Menezes, João Ricardo Lacerda, Moura-Neto, Vivaldo, Tovar-Moll, Fernanda, Lima, Flavia Regina Souza

“…Glioblastoma (GBM) is the most common primary brain tumor and the most aggressive glial tumor. This tumor is highly heterogeneous, angiogenic, and insensitive…”
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Microglia in Cancer: For Good or for Bad? by da Fonseca, Anna Carolina Carvalho, Amaral, Rackele, Garcia, Celina, Geraldo, Luiz Henrique, Matias, Diana, Lima, Flavia Regina Souza

“…Glioblastoma is a malignant tumor of astrocytic origin that is highly invasive, proliferative and angiogenic. Despite current advances in multimodal therapies,…”
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The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiforme tumorigenesis by Oliveira-Nunes, Maria Cecília, Assad Kahn, Suzana, de Oliveira Barbeitas, Ana Luiza, E Spohr, Tania Cristina Leite de Sampaio, Dubois, Luiz Gustavo Feijó, Ventura Matioszek, Grasiella Maria, Querido, William, Campanati, Loraine, de Brito Neto, José Marques, Lima, Flavia Regina Souza, Moura-Neto, Vivaldo, Carneiro, Katia

“…Glioblastoma (GBM) is the most common primary brain tumor presenting self-renewing cancer stem cells. The role of these cells on the development of the tumors…”
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Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages by Carvalho da Fonseca, Anna Carolina, Wang, Huaqing, Fan, Haitao, Chen, Xuebo, Zhang, Ian, Zhang, Leying, Lima, Flavia Regina Souza, Badie, Behnam

“…Abstract Factors released by glioma-associated microglia/macrophages (GAMs) play an important role in the growth and infiltration of tumors. We have previously…”
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CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma by Geraldo, Luiz Henrique, Garcia, Celina, Xu, Yunling, Leser, Felipe Saceanu, Grimaldi, Izabella, de Camargo Magalhães, Eduardo Sabino, Dejaegher, Joost, Solie, Lien, Pereira, Cláudia Maria, Correia, Ana Helena, De Vleeschouwer, Steven, Tavitian, Bertrand, Canedo, Nathalie Henriques Silva, Mathivet, Thomas, Thomas, Jean-Leon, Eichmann, Anne, Lima, Flavia Regina Souza

“…Glioblastoma (GBM) is the most common and fatal primary tumor of the central nervous system (CNS) and current treatments have limited success. Chemokine…”
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EVALUATION OF MIR-181 FAMILY MEMBERS IN ORAL CANCER by DE CARVALHO LYRA, SILVIA MARIA, LIMA, ANA BEATRIZ MACHADO, MOLERI, ANDRÉA BRAGA, LIMA, FLAVIA REGINA SOUZA, DEZONNE, RÔMULO SPERDUTO, DA SILVA BOGHOSSIAN, CARINA MACIEL, PEREIRA, CLAUDIA MARIA

“…Oral cancer is the seventh most frequent type of cancer in the Brazilian population, with high invasiveness, metastasis rates, and recurrence. The main risk…”
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