Search Results - "Reger, Albert S."

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters by Sutton, Margie N., Lu, Zhen, Li, Yao-Cheng, Zhou, Yong, Huang, Tao, Reger, Albert S., Hurwitz, Amy M., Palzkill, Timothy, Logsdon, Craig, Liang, Xiaowen, Gray, Joe W., Nan, Xiaolin, Hancock, John, Wahl, Geoffrey M., Bast, Robert C.

“…Oncogenic RAS mutations drive cancers at many sites. Recent reports suggest that RAS dimerization, multimerization, and clustering correlate strongly with…”
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Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase by Reger, Albert S, Wu, Rui, Dunaway-Mariano, Debra, Gulick, Andrew M

“…Members of the adenylate-forming family of enzymes play a role in the metabolism of halogenated aromatics and of short, medium, and long chain fatty acids, as…”
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I by Huang, Gilbert Y., Kim, Jeong Joo, Reger, Albert S., Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E., Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W., Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W., Kim, Choel

“…Cyclic guanosine monophosphate (cGMP) and cyclic AMP (cAMP)-dependent protein kinases (PKG and PKA) are closely related homologs, and the cyclic nucleotide…”
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Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation by Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel

“…Cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is a key regulator of smooth muscle and vascular tone and represents an important drug…”
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DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells by Lu, Zhen, Baquero, Maria T, Yang, Hailing, Yang, Maojie, Reger, Albert S, Kim, Choel, Levine, Douglas A, Clarke, Charlotte H, Liao, Warren S-L, Bast Jr, Robert C

“…DIRAS3 is an imprinted tumor suppressor gene that is downregulated in 60% of human ovarian cancers. Re-expression of DIRAS3 at physiological levels inhibits…”
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Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase by Reger, Albert S, Carney, Jill M, Gulick, Andrew M

“…The adenylate-forming enzymes, including acyl-CoA synthetases, the adenylation domains of non-ribosomal peptide synthetases (NRPS), and firefly luciferase,…”
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Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions by Reger, Albert S., Yang, Matthew P., Koide-Yoshida, Shizuyo, Guo, Elaine, Mehta, Shrenik, Yuasa, Keizo, Liu, Alan, Casteel, Darren E., Kim, Choel

“…cGMP-dependent protein kinase (PKG)-interacting proteins (GKIPs) mediate cellular targeting of PKG isoforms by interacting with their leucine zipper (LZ)…”
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Mechanism of 4-Chlorobenzoate:Coenzyme A Ligase Catalysis by Wu, Rui, Cao, Jian, Lu, Xuefeng, Reger, Albert S, Gulick, Andrew M, Dunaway-Mariano, Debra

“…Within the accompanying paper in this issue (Reger et al. (2008) Biochemistry, 47, 8016−8025) we reported the X-ray structure of 4-chlorobenzoate:CoA ligase…”
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The Mechanism of Domain Alternation in the Acyl-Adenylate Forming Ligase Superfamily Member 4-Chlorobenzoate: Coenzyme A Ligase by Wu, Rui, Reger, Albert S, Lu, Xuefeng, Gulick, Andrew M, Dunaway-Mariano, Debra

“…4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate…”
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Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase by Reger, Albert S, Wu, Rui, Dunaway-Mariano, Debra, Gulick, Andrew M

“…Members of the adenylate-forming family of enzymes play a role in the metabolism of halogenated aromatics and of short, medium, and long chain fatty acids, as…”
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Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability by Qin, Liying, Reger, Albert S, Guo, Elaine, Yang, Matthew P, Zwart, Peter, Casteel, Darren E, Kim, Choel

“…cGMP-dependent protein kinase (PKG) Iα is a central regulator of smooth muscle tone and vasorelaxation. The N-terminal leucine zipper (LZ) domain dimerizes and…”
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Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II by Campbell, James C., Kim, Jeong Joo, Li, Kevin Y., Huang, Gilbert Y., Reger, Albert S., Matsuda, Shinya, Sankaran, Banumathi, Link, Todd M., Yuasa, Keizo, Ladbury, John E., Casteel, Darren E., Kim, Choel

“…Membrane-bound cGMP-dependent protein kinase (PKG) II is a key regulator of bone growth, renin secretion, and memory formation. Despite its crucial…”
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DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1 by Sutton, Margie N, Huang, Gilbert Y, Liang, Xiaowen, Sharma, Rajesh, Reger, Albert S, Mao, Weiqun, Pang, Lan, Rask, Philip J, Lee, Kwangkook, Gray, Joshua P, Hurwitz, Amy M, Palzkill, Timothy, Millward, Steven W, Kim, Choel, Lu, Zhen, Bast, Jr, Robert C

“…Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role…”
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Erratum to: Lu Z, Baquero MT, Yang H, Yang M, Reger AS, Kim C, Levine DA, Clarke CH, Liao WS, Bast Jr RC. DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cells. Autophagy 2014; 10:1071-92 by Lu, Zhen, Baquero, Maria T, Yang, Hailing, Yang, Maojie, Reger, Albert S, Kim, Choel, Levine, Douglas A, Clarke, Charlotte H, Liao, Warren S-L, Bast Jr, Robert C

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Rational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate:  Coenzyme A Ligase for Expanded Substrate Range by Wu, Rui, Reger, Albert S, Cao, Jian, Gulick, Andrew M, Dunaway-Mariano, Debra

“…Environmental aromatic acids are transformed to chemical energy in bacteria that possess the requisite secondary pathways. Some of these pathways rely on the…”
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Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II by Campbell, James C., Li, Kevin Y., Kim, Jeong Joo, Huang, Gilbert, Reger, Albert S., Matsuda, Shinya, Sankaran, Banumathi, Link, Todd M., Yuasa, Keizo, Ladbury, John E., Kim, Choel

“…As a central mediator of the natriuretic peptide-cGMP signalling cascade, membrane bound type II cGMP dependent protein kinase (PKG II) is a key regulator of…”
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Structures of human PKG reveal cGMP-selectived activation mechanisms by Huang, Gilbert Y, Kim, Jeong J, Reger, Albert S, Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E, Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W, Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W, Kim, Choel

“…Cyclic guanosine monophosphate (cGMP) is a key secondary messenger that is produced in response to nitric oxide. One of the key mediators of cGMP signaling,…”
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Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli by Sundlov, Jesse A., Garringer, Julie A., Carney, Jill M., Reger, Albert S., Drake, Eric J., Duax, William L., Gulick, Andrew M.

“…The Escherichia coli enterobactin synthetic cluster is composed of six proteins, EntA–EntF, that form the enterobactin molecule from three serine molecules and…”
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Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation by Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel

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Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation by Kim, Jeong Joo, Lorenz, Robin, Arold, Stefan T., Reger, Albert S., Sankaran, Banumathi, Casteel, Darren E., Herberg, Friedrich W., Kim, Choel

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