Search Results - "Regenbrecht, Christian R. A."

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures by Schumacher, Dirk, Andrieux, Geoffroy, Boehnke, Karsten, Keil, Marlen, Silvestri, Alessandra, Silvestrov, Maxine, Keilholz, Ulrich, Haybaeck, Johannes, Erdmann, Gerrit, Sachse, Christoph, Templin, Markus, Hoffmann, Jens, Boerries, Melanie, Schäfer, Reinhold, Regenbrecht, Christian R A

“…Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of…”
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The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells by Redmer, Torben, Welte, Yvonne, Behrens, Diana, Fichtner, Iduna, Przybilla, Dorothea, Wruck, Wasco, Yaspo, Marie-Laure, Lehrach, Hans, Schäfer, Reinhold, Regenbrecht, Christian R A

“…Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug…”
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Photon and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models by Roohani, Siyer, Loskutov, Jürgen, Heufelder, Jens, Ehret, Felix, Wedeken, Lena, Regenbrecht, Manuela, Sauer, Rica, Zips, Daniel, Denker, Andrea, Joussen, Antonia M, Regenbrecht, Christian R A, Kaul, David

“…Despite their heterogeneity, the current standard preoperative radiotherapy regimen for localized high-grade soft tissue sarcoma (STS) follows a one fits all…”
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Status of estrogen receptor 1 (ESR1) gene in mastopathy predicts subsequent development of breast cancer by Soysal, Savas D., Kilic, Incken B., Regenbrecht, Christian R. A., Schneider, Sandra, Muenst, Simone, Kilic, Nerbil, Güth, Uwe, Dietel, Manfred, Terracciano, Luigi M., Kilic, Ergin

“…Mastopathy is a common disease of the breast likely associated with elevated estrogen levels and a putative risk factor for breast cancer. The role of estrogen…”
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Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives by Müller, Denise, Loskutov, Jürgen, Küffer, Stefan, Marx, Alexander, Regenbrecht, Christian R A, Ströbel, Philipp, Regenbrecht, Manuela J

“…Cell culture model systems are fundamental tools for studying cancer biology and identifying therapeutic vulnerabilities in a controlled environment. TET cells…”
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Neural cell adhesion molecule isoform 140 declines with rise of WHO grade in human gliomas and serves as indicator for the invasion zone of multiform glioblastomas and brain metastases by Duenisch, Pedro, Reichart, Rupert, Mueller, Ulrike, Brodhun, Michael, Bjerkvig, Rolf, Romeike, Bernd, Walter, Jan, Herbold, Christian, Regenbrecht, Christian R. A, Kalff, Rolf, Kuhn, Susanne A

“…Purpose Gliomas are highly invasive neuroepithelial tumors with a propensity of malignant transformation and very restricted treatment options. The neural cell…”
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Glioblastoma cells express functional cell membrane receptors activated by daily used medical drugs by Kuhn, Susanne A., Mueller, Ulrike, Hanisch, Uwe-K., Regenbrecht, Christian R. A., Schoenwald, Ilona, Brodhun, Michael, Kosmehl, Hartwig, Ewald, Christian, Kalff, Rolf, Reichart, Rupert

“…Purpose Calcium ions are highly versatile spacial and temporal intracellular signals of non-excitable cells and have an important impact on nearly every aspect…”
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From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity by Gambara, Guido, Gaebler, Manuela, Keilholz, Ulrich, Regenbrecht, Christian R A, Silvestri, Alessandra

“…Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of…”
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Three-Dimensional Patient-Derived In Vitro Sarcoma Models: Promising Tools for Improving Clinical Tumor Management by Gaebler, Manuela, Silvestri, Alessandra, Haybaeck, Johannes, Reichardt, Peter, Lowery, Caitlin D, Stancato, Louis F, Zybarth, Gabriele, Regenbrecht, Christian R A

“…Over the past decade, the development of new targeted therapeutics directed against specific molecular pathways involved in tumor cell proliferation and…”
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Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer by Sankarasubramanian, Sushmitha, Pfohl, Ulrike, Regenbrecht, Christian R. A., Reinhard, Christoph, Wedeken, Lena

“…Pancreatic cancer is one of the deadliest cancers and remains a major unsolved health problem. While pancreatic ductal adenocarcinoma (PDAC) is associated with…”
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Precision Oncology Beyond Genomics: The Future Is Here—It Is Just Not Evenly Distributed by Pfohl, Ulrike, Pflaume, Alina, Regenbrecht, Manuela, Finkler, Sabine, Graf Adelmann, Quirin, Reinhard, Christoph, Regenbrecht, Christian, Wedeken, Lena

“…Cancer is a multifactorial disease with increasing incidence. There are more than 100 different cancer types, defined by location, cell of origin, and genomic…”
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Characterization of small spheres derived from various solid tumor cell lines: are they suitable targets for T cells? by Busse, Antonia, Letsch, Anne, Fusi, Alberto, Nonnenmacher, Anika, Stather, David, Ochsenreither, Sebastian, Regenbrecht, Christian RA, Keilholz, Ulrich

“…T cell based immunotherapy has been investigated in a variety of malignancies and analyses have been mostly founded on in vitro data with tumor cell…”
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Data management strategies for multinational large-scale systems biology projects by Wruck, Wasco, Peuker, Martin, Regenbrecht, Christian R A

“…Good accessibility of publicly funded research data is essential to secure an open scientific system and eventually becomes mandatory [Wellcome Trust will…”
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors by Schütte, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildiriman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans- Jörg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schäfer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure

“…Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular…”
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Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells by Regan, Joseph L., Schumacher, Dirk, Staudte, Stephanie, Steffen, Andreas, Haybaeck, Johannes, Keilholz, Ulrich, Schweiger, Caroline, Golob-Schwarzl, Nicole, Mumberg, Dominik, Henderson, David, Lehrach, Hans, Regenbrecht, Christian R.A., Schäfer, Reinhold, Lange, Martin

“…Colon cancer is a heterogeneous tumor driven by a subpopulation of cancer stem cells (CSCs). To study CSCs in colon cancer, we used limiting dilution spheroid…”
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Cancer stem cells in solid tumors: elusive or illusive? by Welte, Yvonne, Adjaye, James, Lehrach, Hans R, Regenbrecht, Christian Ra

“…During the past years in vivo transplantation experiments and in vitro colony-forming assays indicated that tumors arise only from rare cells. These cells were…”
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Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures by Boehnke, Karsten, Iversen, Philip W, Schumacher, Dirk, Lallena, María José, Haro, Rubén, Amat, Joaquín, Haybaeck, Johannes, Liebs, Sandra, Lange, Martin, Schäfer, Reinhold, Regenbrecht, Christian R A, Reinhard, Christoph, Velasco, Juan A

“…The application of patient-derived three-dimensional culture systems as disease-specific drug sensitivity models has enormous potential to connect compound…”
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Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model by Banning, Antje, Regenbrecht, Christian R.A., Tikkanen, Ritva

“…Flotillins are highly conserved and widely spread proteins that function in receptor tyrosine kinase signaling and membrane trafficking processes. Flotillin-1…”
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Reflection of neuroblastoma intratumor heterogeneity in the new OHC‐NB1 disease model by Thole, Theresa M., Toedling, Joern, Sprüssel, Annika, Pfeil, Sebastian, Savelyeva, Larissa, Capper, David, Messerschmidt, Clemens, Beule, Dieter, Groeneveld‐Krentz, Stefanie, Eckert, Cornelia, Gambara, Guido, Henssen, Anton G., Finkler, Sabine, Schulte, Johannes H., Sieber, Anja, Bluethgen, Nils, Regenbrecht, Christian R. A., Künkele, Annette, Lodrini, Marco, Eggert, Angelika, Deubzer, Hedwig E.

“…Accurate modeling of intratumor heterogeneity presents a bottleneck against drug testing. Flexibility in a preclinical platform is also desirable to support…”
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A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer by Pfohl, Ulrike, Loskutov, Jürgen, Bashir, Sanum, Kühn, Ralf, Herter, Patrick, Templin, Markus, Mamlouk, Soulafa, Belanov, Sergei, Linnebacher, Michael, Bürtin, Florian, Vetter, Marcus, Reinhard, Christoph, Wedeken, Lena, Regenbrecht, Christian R. A.

“…Background: In colorectal cancer (CRC), mutations of genes associated with the TGF-β/BMP signaling pathway, particularly affecting SMAD4, are known to…”
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