Search Results - "Regehr, G."

The Mechanisms and Functions of Synaptic Facilitation by Jackman, Skyler L., Regehr, Wade G.

“…The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of…”
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Short-term presynaptic plasticity by Regehr, Wade G

“…Different types of synapses are specialized to interpret spike trains in their own way by virtue of the complement of short-term synaptic plasticity mechanisms…”
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Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release by Kaeser, Pascal S, Regehr, Wade G

“…Most neuronal communication relies upon the synchronous release of neurotransmitters, which occurs through synaptic vesicle exocytosis triggered by action…”
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Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses by Turecek, Josef, Regehr, Wade G

“…When an action potential invades a presynaptic terminal it evokes large, brief Ca signals that trigger vesicle fusion within milliseconds that is followed by a…”
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A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types by Kozareva, Velina, Martin, Caroline, Osorno, Tomas, Rudolph, Stephanie, Guo, Chong, Vanderburg, Charles, Nadaf, Naeem, Regev, Aviv, Regehr, Wade G., Macosko, Evan

“…The cerebellar cortex is a well-studied brain structure with diverse roles in motor learning, coordination, cognition and autonomic regulation. However,  a…”
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Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release by Turecek, Josef, Regehr, Wade G.

“…Neurotransmitter release can be synchronous and occur within milliseconds of action potential invasion, or asynchronous and persist for tens of milliseconds…”
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Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells by Han, Kyung-Seok, Guo, Chong, Chen, Christopher H., Witter, Laurens, Osorno, Tomas, Regehr, Wade G.

“…Correlated neuronal activity at various timescales plays an important role in information transfer and processing. We find that in awake-behaving mice, an…”
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Identification of an Inhibitory Circuit that Regulates Cerebellar Golgi Cell Activity by Hull, Court, Regehr, Wade G.

“…Here we provide evidence that revises the inhibitory circuit diagram of the cerebellar cortex. It was previously thought that Golgi cells, interneurons that…”
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Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool by Thanawala, Monica S, Regehr, Wade G

“…The steep calcium dependence of synaptic strength that has been observed at many synapses is thought to reflect a calcium dependence of the probability of…”
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Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells by Guo, Chong, Huson, Vincent, Macosko, Evan Z., Regehr, Wade G.

“…Many neuron types consist of populations with continuously varying molecular properties. Here, we show a continuum of postsynaptic molecular properties in…”
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Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons by Witter, Laurens, Rudolph, Stephanie, Pressler, R. Todd, Lahlaf, Safiya I., Regehr, Wade G.

“…Purkinje cells (PCs) provide the sole output from the cerebellar cortex. Although PCs are well characterized on many levels, surprisingly little is known about…”
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Achieving high-frequency optical control of synaptic transmission by Jackman, Skyler L, Beneduce, Brandon M, Drew, Iain R, Regehr, Wade G

“…The optogenetic tool channelrhodopsin-2 (ChR2) is widely used to excite neurons to study neural circuits. Previous optogenetic studies of synapses suggest that…”
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Short-term synaptic plasticity by Zucker, Robert S, Regehr, Wade G

“…Synaptic transmission is a dynamic process. Postsynaptic responses wax and wane as presynaptic activity evolves. This prominent characteristic of chemical…”
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Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex by Guo, Chong, Witter, Laurens, Rudolph, Stephanie, Elliott, Hunter L., Ennis, Katelin A., Regehr, Wade G.

“…Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons…”
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Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain by Yamada, Tomoko, Yang, Yue, Hemberg, Martin, Yoshida, Toshimi, Cho, Ha Young, Murphy, J. Patrick, Fioravante, Diasynou, Regehr, Wade G., Gygi, Steven P., Georgopoulos, Katia, Bonni, Azad

“…Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained…”
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Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje Cells by Kreitzer, Anatol C, Regehr, Wade G

“…Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced…”
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Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters by Turecek, Josef, Regehr, Wade G

“…The inferior olive (IO) is composed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells. Neurons in different IO subnuclei…”
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Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex by Turecek, Josef, Jackman, Skyler L., Regehr, Wade G.

“…The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cells (PCs). Here, we characterize the properties of the PC-DCN…”
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Inhibitory Regulation of Electrically Coupled Neurons in the Inferior Olive Is Mediated by Asynchronous Release of GABA by Best, Aaron R., Regehr, Wade G.

“…Inhibitory projection neurons in the deep cerebellar nuclei (DCN) provide GABAergic input to neurons of the inferior olive (IO) that in turn produce climbing…”
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Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex by Guo, Chong, Rudolph, Stephanie, Neuwirth, Morgan E, Regehr, Wade G

“…Circuitry of the cerebellar cortex is regionally and functionally specialized. Unipolar brush cells (UBCs), and Purkinje cell (PC) synapses made by axon…”
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