Search Results - "Rege, Juilee"

11-Oxygenated androgens in health and disease by Turcu, Adina F., Rege, Juilee, Auchus, Richard J., Rainey, William E.

“…The adrenal gland is a source of sex steroid precursors, and its activity is particularly relevant during fetal development and adrenarche. Following puberty,…”
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11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche by Rege, Juilee, Turcu, Adina F, Kasa-Vubu, Josephine Z, Lerario, Antonio M, Auchus, Gabriela C, Auchus, Richard J, Smith, Joshua M, White, Perrin C, Rainey, William E

“…Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S) associated with the development of a functional adrenal zona reticularis. Clinical…”
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Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood by Davio, Angela, Woolcock, Helen, Nanba, Aya T, Rege, Juilee, O’Day, Patrick, Ren, Jianwei, Zhao, Lili, Ebina, Hiroki, Auchus, Richard, Rainey, William E, Turcu, Adina F

“…Abstract Context The gonads are the major source of sex steroids during reproductive ages. The gonadal function declines abruptly in women and gradually in…”
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The steroid metabolome of adrenarche by Rege, Juilee, Rainey, William E

“…Adrenarche is an endocrine developmental process whereby humans and select nonhuman primates increase adrenal output of a series of steroids, especially DHEA…”
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Liquid Chromatography–Tandem Mass Spectrometry Analysis of Human Adrenal Vein 19-Carbon Steroids Before and After ACTH Stimulation by Rege, Juilee, Nakamura, Yasuhiro, Satoh, Fumitoshi, Morimoto, Ryo, Kennedy, Michael R, Layman, Lawrence C, Honma, Seijiro, Sasano, Hironobu, Rainey, William E

“…Context: A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been reported. This is the first study that uses liquid…”
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Circulating 11-oxygenated androgens across species by Rege, Juilee, Garber, Scott, Conley, Alan J., Elsey, Ruth M., Turcu, Adina F., Auchus, Richard J., Rainey, William E.

“…•11-oxygenated androgens, as well as DHEA and DHEAS were quantified using LC–MS/MS in 18 animal species.•The serum concentration of DHEA and DHEAS in sexually…”
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Targeted Mutational Analysis of Cortisol-Producing Adenomas by Rege, Juilee, Hoxie, Jessie, Liu, Chia-Jen, Cash, Morgan N, Luther, James M, Gellert, Lan, Turcu, Adina F, Else, Tobias, Giordano, Thomas J, Udager, Aaron M, Rainey, William E, Nanba, Kazutaka

“…Somatic gene mutations have been identified in only about half of cortisol-producing adenomas (CPAs). Affected genes include PRKACA, GNAS, PRKAR1A, and CTNNB1…”
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Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency by Turcu, Adina F, Rege, Juilee, Chomic, Robert, Liu, Jiayan, Nishimoto, Hiromi K, Else, Tobias, Moraitis, Andreas G, Palapattu, Ganesh S, Rainey, William E, Auchus, Richard J

“…Context: Marked elevations of 17-hydroxyprogesterone (17OHP) are characteristic of classic 21-hydroxylase deficiency (21OHD). Testing of 17OHP provides the…”
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Transcriptome Profiling Reveals Differentially Expressed Transcripts Between the Human Adrenal Zona Fasciculata and Zona Reticularis by Rege, Juilee, Nakamura, Yasuhiro, Wang, Tao, Merchen, Todd D, Sasano, Hironobu, Rainey, William E

“…Context: The human adrenal zona fasciculata (ZF) and zona reticularis (ZR) are responsible for the production of cortisol and 19-carbon steroids (often called…”
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Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry by Teuber, James P., Nanba, Kazutaka, Turcu, Adina F., Chen, Xuan, Zhao, Lili, Else, Tobias, Auchus, Richard J., Rainey, William E., Rege, Juilee

“…•19 steroids were measured from OCT-embedded CPA and normal adjacent adrenal (AdjN) tissue samples.•CYP17A1 and HSD3B2 immunohistochemistry confirmed the…”
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Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate by Rege, Juilee, Karashima, Shigehiro, Lerario, Antonio M, Smith, Joshua M, Auchus, Richard J, Kasa-Vubu, Josephine Z, Sasano, Hironobu, Nakamura, Yasuhiro, White, Perrin C, Rainey, William E

“…Context: Adrenal production of dehydroepiandrosterone sulfate (DHEA-S) increases throughout childhood owing to expansion of the zona reticularis (ZR). ZR…”
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Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations by Lim, Jung Soo, Plaska, Samuel W, Rege, Juilee, Rainey, William E, Turcu, Adina F

“…Somatic gene mutations that facilitate inappropriate intracellular calcium entrance have been identified in most aldosterone-producing adenomas (APAs). Studies…”
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Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis by Ghayee, Hans K, Xu, Yiling, Hatch, Heather, Brockway, Richard, Multani, Asha S, Gu, Tongjun, Bollag, Wendy B, Turcu, Adina, Rainey, William E, Rege, Juilee, Nanba, Kazutaka, Bhagwandin, Vikash J, Nwariaku, Fiemu, Stastny, Victor, Gazdar, Adi F, Shay, Jerry W, Auchus, Richard J, Tevosian, Sergei G

“…The human adrenal cortex is composed of distinct zones that are the main source of steroid hormone production. The mechanism of adrenocortical cell…”
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Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis by Rege, Juilee, Nishimoto, Hiromi Koso, Nishimoto, Koshiro, Rodgers, Raymond J, Auchus, Richard J, Rainey, William E

“…Bone morphogenetic proteins (BMPs) comprise one of the largest subgroups in the TGF-β ligand superfamily. We have identified a functional BMP system equipped…”
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Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas by Rege, Juilee, Nanba, Kazutaka, Blinder, Amy R, Plaska, Samuel, Udager, Aaron M, Vats, Pankaj, Kumar-Sinha, Chandan, Giordano, Thomas J, Rainey, William E, Else, Tobias

“…Abstract Somatic mutations driving aldosterone production have been identified in approximately 90% of aldosterone-producing adenomas (APAs) using an…”
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Transcriptomic Response Dynamics of Human Primary and Immortalized Adrenocortical Cells to Steroidogenic Stimuli by Wellman, Kimberly, Fu, Rui, Baldwin, Amber, Rege, Juilee, Murphy, Elisabeth, Rainey, William E., Mukherjee, Neelanjan

“…Adrenal steroid hormone production is a dynamic process stimulated by adrenocorticotropic hormone (ACTH) and angiotensin II (AngII). These ligands initialize a…”
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11-Oxygenated C19 Steroids Do Not Decline With Age in Women by Nanba, Aya T, Rege, Juilee, Ren, Jianwei, Auchus, Richard J, Rainey, William E, Turcu, Adina F

“…Abstract Context The ovaries and adrenals are sources of androgens in women. Although dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and testosterone (T)…”
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Human Gonads Do Not Contribute to the Circulating Pool of 11-Oxygenated Androgens by Charoensri, Suranut, Rege, Juilee, Lee, Chaelin, Marko, Xhorlina, Sherk, William, Sholinyan, Julieta, Rainey, William E, Turcu, Adina F

“…Androstenedione (A4) and testosterone (T) are produced by both the adrenal glands and the gonads. The adrenal enzyme 11β-hydroxylase (CYP11B1) executes the…”
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Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma by Nanba, Kazutaka, Blinder, Amy R., Rege, Juilee, Hattangady, Namita G., Else, Tobias, Liu, Chia-Jen, Tomlins, Scott A., Vats, Pankaj, Kumar-Sinha, Chandan, Giordano, Thomas J., Rainey, William E.

“…Driver somatic mutations for aldosterone excess have been found in ≈90% of aldosterone-producing adenomas (APAs) using an aldosterone synthase (CYP11B2)-guided…”
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An in Vitro triple screen model for human mineralocorticoid receptor activity by Liu, Haiping, Konzen, Sonja, Coy, Asha, Rege, Juilee, Gomez-Sanchez, Celso E., Rainey, William E., Turcu, Adina F.

“…The mineralocorticoid receptor (MR, NR3C2) mediates ion and water homeostasis in epithelial cells of the distal nephron and other tissues. Aldosterone, the…”
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