Search Results - "Regan, Samantha L"

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers by Regan, Samantha L., Hufgard, Jillian R., Pitzer, Emily M., Sugimoto, Chiho, Hu, Yueh-Chiang, Williams, Michael T., Vorhees, Charles V.

“…Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75–90%…”
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A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats by Regan, Samantha L., Pitzer, Emily M., Hufgard, Jillian R., Sugimoto, Chiho, Williams, Michael T., Vorhees, Charles V.

“…Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate,…”
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Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model by Williams, Michael T, Sugimoto, Chiho, Regan, Samantha L, Pitzer, Emily M, Fritz, Adam L, Sertorio, Mathieu, Mascia, Anthony E, Vatner, Ralph E, Perentesis, John P, Vorhees, Charles V

“…Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive…”
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Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague–Dawley rats by Gutierrez, Arnold, Regan, Samantha L., Hoover, Christopher S., Williams, Michael T., Vorhees, Charles V.

“…Rationale Methamphetamine (MA) is an abused psychostimulant that causes cognitive deficits after chronic use. Neostriatal dopamine receptors play a role in MA…”
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Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats by Regan, Samantha L, Cryan, Michael T, Williams, Michael T, Vorhees, Charles V, Ross, Ashley E

“…Latrophilin-3 (LPHN3) is an adhesion G protein coupled receptor involved in regulating neuroplasticity. Variants of LPHN3 are associated with increased risk of…”
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Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects by Williams, Michael T., Sugimoto, Chiho, Regan, Samantha L., Pitzer, Emily M., Fritz, Adam L., Mascia, Anthony E., Sertorio, Mathieu, Vatner, Ralph E., Perentesis, John P., Vorhees, Charles V.

“…Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of…”
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Impulsive choice in two different rat models of ADHD-Spontaneously hypertensive and Lphn3 knockout rats by Carbajal, Monica S, Bounmy, Asiah J C, Harrison, Olivia B, Nolen, Hunter G, Regan, Samantha L, Williams, Michael T, Vorhees, Charles V, Sable, Helen J K

“…Impulsivity is a symptom of attention-deficit/hyperactivity disorder (ADHD) and variants in the ) gene (OMIM 616417) have been linked to ADHD. This project…”
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Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats by Pitzer, Emily M., Sugimoto, Chiho, Regan, Samantha L., Gudelsky, Gary A., Williams, Michael T., Vorhees, Charles V.

“…[Display omitted] •Low dose deltamethrin (DLM) effects have been reported in developing rodents.•Rats treated with DLM from P3-20 showed effects on NMDA-NR2A…”
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Review of rodent models of attention deficit hyperactivity disorder by Regan, Samantha L., Williams, Michael T., Vorhees, Charles V.

“…•ADHD is polygenic with multiple small effect gene variants contributing.•ADHD is associated with some environmental chemical or drug exposures.•Selectively…”
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Subsecond spontaneous catecholamine release in mesenteric lymph node ex vivo by Lim, Gary N., Regan, Samantha L., Ross, Ashley E.

“…Measuring the dynamics of neurochemical‐regulated immunity, particularly in the gut, has been a growing interest over the last several years because of its…”
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Latrophilin-3 disruption: Effects on brain and behavior by Regan, Samantha L., Williams, Michael T., Vorhees, Charles V.

“…•Latrophilins are adhesion G-protein-coupled receptors.•Latrophilin-3 (Lphn3) is a trans-synaptic regulator of synaptic function.•21 gene variants of LPHN3 are…”
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H2A monoubiquitination: insights from human genetics and animal models by Ryan, Charles W., Peirent, Emily R., Regan, Samantha L., Guxholli, Alba, Bielas, Stephanie L.

“…Metazoan development arises from spatiotemporal control of gene expression, which depends on epigenetic regulators like the polycomb group proteins (PcG) that…”
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Latrophilin‐3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity by Regan, Samantha L., Sugimoto, Chiho, Dawson, Hannah E., Williams, Michael T., Vorhees, Charles V.

“…Latrophilin‐3 (LPHN3) is a brain specific G‐protein coupled receptor associated with increased risk of attention deficit hyperactivity disorder (ADHD) and…”
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A better approach to in vivo developmental neurotoxicity assessment: Alignment of rodent testing with effects seen in children after neurotoxic exposures by Vorhees, Charles V., Sprowles, Jenna N., Regan, Samantha L., Williams, Michael T.

“…High throughput screens for developmental neurotoxicity (DN) will facilitate evaluation of chemicals and can be used to prioritize those designated for…”
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TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome by Werren, Elizabeth A., LaForce, Geneva R., Srivastava, Anshika, Perillo, Delia R., Li, Shaokun, Johnson, Katherine, Baris, Safa, Berger, Brandon, Regan, Samantha L., Pfennig, Christian D., de Munnik, Sonja, Pfundt, Rolph, Hebbar, Malavika, Jimenez-Heredia, Raúl, Karakoc-Aydiner, Elif, Ozen, Ahmet, Dmytrus, Jasmin, Krolo, Ana, Corning, Ken, Prijoles, E. J., Louie, Raymond J., Lebel, Robert Roger, Le, Thuy-Linh, Amiel, Jeanne, Gordon, Christopher T., Boztug, Kaan, Girisha, Katta M., Shukla, Anju, Bielas, Stephanie L., Schaffer, Ashleigh E.

“…THOC6 variants are the genetic basis of autosomal recessive THOC6 Intellectual Disability Syndrome (TIDS). THOC6 is critical for mammalian Transcription Export…”
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Effects of Permethrin or Deltamethrin Exposure in Adult Sprague Dawley Rats on Acoustic and Light Prepulse Inhibition of Acoustic or Tactile Startle by Regan, Samantha L., Sugimoto, Chiho, Fritz, Adam L., Vorhees, Charles V., Williams, Michael T.

“…The effects of permethrin (PRM) and deltamethrin (DLM) on acoustic or light prepulse inhibition of the acoustic startle response (ASR) and tactile startle…”
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An assessment of executive function in two different rat models of attention‐deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats by Sable, Helen J. K., Lester, Deranda B., Potter, Joshua L., Nolen, Hunter G., Cruthird, Destinee M., Estes, Lauren M., Johnson, Alyssa D., Regan, Samantha L., Williams, Michael T., Vorhees, Charles V.

“…Attention‐deficit/hyperactivity disorder (ADHD) a common neurodevelopmental disorder of childhood and often comorbid with other externalizing disorders (EDs)…”
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A Gad2 specific Slc6a8 deletion recapitulates the contextual and cued freezing deficits seen in Slc6a8 mice by Sugimoto, Chiho, Perna, Marla K., Regan, Samantha L., Tepe, Erin A., Liou, Rosalyn, Fritz, Adam L., Williams, Michael T., Vorhees, Charles V., Skelton, Matthew R.

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Cognitive and behavioral effects of whole brain conventional or high dose rate by Williams, Michael T, Sugimoto, Chiho, Regan, Samantha L, Pitzer, Emily M, Fritz, Adam L, Sertorio, Mathieu, Mascia, Anthony E, Vatner, Ralph E, Perentesis, John P, Vorhees, Charles V

“…Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive…”
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3174: Effects of whole brain conventional or FLASH proton irradiation in Sprague Dawley rats by Vorhees, Charles V., Sugimoto, Chiho, Regan, Samantha L., Pitzer, Emily M., Fritz, Adam L., Gollaway, Brooke M., Sertorio, Mathieu, Mascia, Anthony E., Vatner, Ralph E., Parentesis, John P., Williams, Michael T.

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