Search Results - "Regan, R F"

Interactions between NO, CO and an endothelium‐derived hyperpolarizing factor (EDHF) in maintaining patency of the ductus arteriosus in the mouse by Baragatti, B, Brizzi, F, Barogi, S, Laubach, V E, Sodini, D, Shesely, E G, Regan, R F, Coceani, F

“…Background and purpose: Prenatal patency of ductus arteriosus is maintained by prostaglandin (PG) E2, possibly along with nitric oxide (NO) and carbon monoxide…”
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Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury by Regan, R.F, Kumar, N, Gao, F, Guo, Y

“…Hemin is released from hemoglobin after CNS hemorrhage and may contribute to its cytotoxic effect. In a prior study, we demonstrated that heme oxygenase-1…”
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Heme oxygenase-1 induction protects murine cortical astrocytes from hemoglobin toxicity by Regan, Raymond F, Guo, Yaping, Kumar, Nidhi

“…Exposure to micromolar concentrations of hemoglobin (Hb) results in the oxidative death of cultured cortical neurons, but glia are resistant. The role of heme…”
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The Effect of Magnesium on Oxidative Neuronal Injury In Vitro by Regan, Raymond F., Jasper, Edward, Guo, Yaping, Panter, S. Scott

“…: The effect of magnesium on the oxidative neuronal injury induced by hemoglobin was assessed in murine cortical cell cultures. Exposure to 5 µM hemoglobin in…”
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Glutamate neurotoxicity in spinal cord cell culture by Regan, R F, Choi, D W

“…The neurotoxicity of glutamate was investigated quantitatively in mixed neuronal and glial spinal cord cell cultures from fetal mice at 12-13 days of…”
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Hemin uptake and release by neurons and glia by Chen-Roetling, J, Cai, Y, Lu, X, Regan, R F

“…Hemin accumulates in intracerebral hematomas and may contribute to cell injury in adjacent tissue. Despite its relevance to hemorrhagic CNS insults, very…”
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Neurotoxicity of hemoglobin in cortical cell culture by Regan, R F, Panter, S S

“…Hemoglobin (Hb) has been demonstrated to be neurotoxic when injected into the cerebral cortex in vivo. However, associated systemic factors such as ischemia…”
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Toxic effect of hemoglobin on spinal cord neurons in culture by Regan, R F, Guo, Y

“…The vulnerability of spinal cord neurons to hemoglobin was quantitatively assessed in primary cultures derived from fetal mice. Exposure to hemoglobin for 28 h…”
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Ultrastructure of excitotoxic neuronal death in murine cortical culture by Regan, R.F., Panter, S.S., Witz, A., Tilly, J.L., Giffard, R.G.

“…Ischemic and traumatic brain injury are likely to involve neuronal injury triggered by glutamate receptor overactivation. Although excitotoxic neuronal injury…”
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Hemoglobin potentiates excitotoxic injury in cortical cell culture by Regan, R F, Panter, S S

“…Excessive activation of glutamate receptors may contribute to neuronal loss after a traumatic or ischemic central nervous system insult. Such injuries are…”
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Potentiation of excitotoxic injury by high concentrations of extracellular reduced glutathione by Regan, R.F, Guo, Y.P

“…Glutathione is present in the central nervous system in millimolar concentrations, and is a predominant intracellular antioxidant and detoxicant. In addition,…”
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The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture by Regan, R F, Choi, D W

“…A traumatic insult was delivered to murine cortical neuronal and glial cell cultures by tearing the cell layer with a stylet in a grid pattern. Consistent with…”
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The vulnerability of spinal cord neurons to excitotoxic injury: Comparison with cortical neurons by Regan, Raymond F

“…The neurotoxicity of the glutamate receptor agonists N-methyl- d-aspartate (NMDA), (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainate…”
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Extracellular reduced glutathione increases neuronal vulnerability to combined chemical hypoxia and glucose deprivation by Regan, Raymond F, Guo, Yaping

“…In addition to its intracellular antioxidant role, reduced glutathione (GSH) is released by CNS cells and may mediate or modulate excitatory neurotransmission…”
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Hemin induces an iron-dependent, oxidative injury to human neuron-like cells by Goldstein, Laurel, Teng, Zhi-Peng, Zeserson, Eli, Patel, Monica, Regan, Raymond F.

“…Hemin is released from hemoglobin after CNS hemorrhage and is present at high micromolar concentrations in intracranial hematomas. This highly reactive…”
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Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity by Rogers, Bret, Yakopson, Vladimir, Teng, Zhi-Ping, Guo, Yaping, Regan, Raymond F

“…When cortical neurons are exposed to hemoglobin, they undergo oxidative stress that ultimately results in iron-dependent cell death. Heme oxygenase (HO)-2 is…”
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Heme oxygenase-2 gene deletion increases astrocyte vulnerability to hemin by Chen, Jing, Regan, Raymond F

“…In a prior study, we observed that heme oxygenase-2 gene deletion protected murine cortical neurons from heme-mediated injury. In the course of these studies,…”
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NMDA neurotoxicity in murine cortical cell cultures is not attenuated by hemoglobin or inhibition of nitric oxide synthesis by Regan, R F, Renn, K E, Panter, S S

“…The role of nitric oxide in N-methyl-D-aspartate (NMDA) neurotoxicity was investigated in murine cortical cell cultures. Exposure of cultures to 300 microM…”
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Traumatic neuronal injury in cortical cell culture is attenuated by 21-aminosteroids by Regan, Raymond F., Panter, S. Scott

“…The effect of the 21-aminosteroids U74500A and U74389F, alone and in combination with the NMDA receptor antagonist MK-801, on traumatic neuronal injury was…”
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Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures by Regan, Raymond F, Guo, Yaping

“…A growing body of evidence supports the hypothesis that estrogens may be beneficial in Alzheimer's disease and other neurodegenerative processes. Less is known…”
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