Search Results - "Regan, Kevin M"
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CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage
Published in Science (American Association for the Advancement of Science) (13-10-2006)“…The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage--induced cell…”
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2
Skp2 Inhibits FOXO1 in Tumor Suppression through Ubiquitin-Mediated Degradation
Published in Proceedings of the National Academy of Sciences - PNAS (01-02-2005)“…Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis…”
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3
RhoA as a Mediator of Clinically Relevant Androgen Action in Prostate Cancer Cells
Published in Molecular endocrinology (Baltimore, Md.) (01-05-2012)“…Recently, we have identified serum response factor (SRF) as a mediator of clinically relevant androgen receptor (AR) action in prostate cancer (PCa). Genes…”
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Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion-independent prostate cancer cells
Published in Cancer research (Chicago, Ill.) (15-10-2007)“…Systemic prostate cancer therapy requires androgen ablation, which inhibits the production or action of androgens. Prostate cancer ultimately relapses during…”
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5
Androgen Modulation of Coregulator Expression in Prostate Cancer Cells
Published in Molecular endocrinology (Baltimore, Md.) (01-04-2009)“…Aberrant coregulator expression that occurs during prostate cancer (PCa) progression correlates with poor prognosis and aggressive disease. This has been…”
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Androgen Induction of the Androgen Receptor Coactivator Four and a Half LIM Domain Protein-2: Evidence for a Role for Serum Response Factor in Prostate Cancer
Published in Cancer research (Chicago, Ill.) (01-11-2007)“…Androgen receptor (AR) activity is critical for prostate cancer progression. Overexpression of several AR-associated coactivators has been shown to be…”
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7
Androgen deprivation increases p300 expression in prostate cancer cells
Published in Cancer research (Chicago, Ill.) (01-04-2007)“…Standard therapy for nonorgan confined prostate cancer aims to block the production or action of androgens. Although initially successful, antiandrogen therapy…”
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Identification of a Clinically Relevant Androgen-Dependent Gene Signature in Prostate Cancer
Published in Cancer research (Chicago, Ill.) (01-03-2011)“…The androgen receptor (AR) is the principal target for treatment of non-organ-confined prostate cancer (PCa). Androgen deprivation therapies (ADT) directed…”
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Androgens repress expression of the f-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells
Published in The Prostate (01-02-2012)“…BACKGROUND Androgens control homeostasis of the normal prostate and growth of prostate cancer (PCa) through the androgen receptor (AR) by regulating gene…”
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Higher Prevalence of Babesia microti than Borrelia burgdorferi in Small Mammal Species in Central Pennsylvania, United States
Published in Vector borne and zoonotic diseases (Larchmont, N.Y.) (01-02-2020)“…can lead to severe babesiosis in immunosuppressed populations, but due to high numbers of asymptomatic cases, clinical reporting is unable to define its…”
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CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy
Published in Cancer research (Chicago, Ill.) (01-04-2014)“…Despite the high incidence and mortality of prostate cancer, the etiology of this disease is not fully understood. In this study, we develop functional…”
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Differential regulation of steroid nuclear receptor coregulator expression between normal and neoplastic prostate epithelial cells
Published in The Prostate (15-06-2010)“…BACKGROUND Deregulated androgen receptor (AR) action is critical for prostate cancer (PCa) progression. Aberrant expression of AR‐associated coregulators…”
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13
Effects of the 5 alpha-reductase inhibitor dutasteride on gene expression in prostate cancer xenografts
Published in The Prostate (01-12-2009)“…BACKGROUND In the prostate, androgens play a crucial role in normal and cancerous growth; hence the androgenic pathway has become a target of therapeutic…”
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Abstract 2924: Constitutively active androgen receptor splice variants function independently of full-length androgen receptor in a cell-based model of castrate-resistant prostate cancer
Published in Cancer research (Chicago, Ill.) (15-04-2012)“…Abstract Recent studies suggest that progression to castrate-resistant prostate cancer (CRPC) is due to generation of androgen receptor (AR) splice variants,…”
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15
Selective Role of an NH sub(2)-Terminal WxxLF Motif for Aberrant Androgen Receptor Activation in Androgen Depletion-Independent Prostate Cancer Cells
Published in Cancer research (Chicago, Ill.) (01-10-2007)“…Systemic prostate cancer therapy requires androgen ablation, which inhibits the production or action of androgens. Prostate cancer ultimately relapses during…”
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Journal Article -
16
CDK2-dependent phosphorylation of F0X01 as an apoptotic response to DNA damage
Published in Science (American Association for the Advancement of Science) (13-10-2006)“…The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell…”
Get full text
Journal Article