Search Results - "Regan, Kevin M"

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  1. 1

    CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage by Huang, Haojie, Regan, Kevin M., Lou, Zhenkun, Chen, Junjie, Tindall, Donald J.

    “…The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage--induced cell…”
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  2. 2

    Skp2 Inhibits FOXO1 in Tumor Suppression through Ubiquitin-Mediated Degradation by Huang, Haojie, Regan, Kevin M., Wang, Fang, Wang, Diping, Smith, David I., Jan M. A. van Deursen, Tindall, Donald J., Hershko, Avram

    “…Forkhead transcription factors FOXO1 (FKHR), FOXO3a (FKHRL1), and FOXO4 (AFX) play a pivotal role in tumor suppression by inducing growth arrest and apoptosis…”
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  3. 3

    RhoA as a Mediator of Clinically Relevant Androgen Action in Prostate Cancer Cells by Schmidt, Lucy J, Duncan, Kelly, Yadav, Neelu, Regan, Kevin M, Verone, Alissa R, Lohse, Christine M, Pop, Elena A, Attwood, Kristopher, Wilding, Gregory, Mohler, James L, Sebo, Thomas J, Tindall, Donald J, Heemers, Hannelore V

    Published in Molecular endocrinology (Baltimore, Md.) (01-05-2012)
    “…Recently, we have identified serum response factor (SRF) as a mediator of clinically relevant androgen receptor (AR) action in prostate cancer (PCa). Genes…”
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  4. 4

    Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion-independent prostate cancer cells by DEHM, Scott M, REGAN, Kevin M, SCHMIDT, Lucy J, TINDALL, Donald J

    Published in Cancer research (Chicago, Ill.) (15-10-2007)
    “…Systemic prostate cancer therapy requires androgen ablation, which inhibits the production or action of androgens. Prostate cancer ultimately relapses during…”
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  5. 5

    Androgen Modulation of Coregulator Expression in Prostate Cancer Cells by Heemers, Hannelore V, Regan, Kevin M, Schmidt, Lucy J, Anderson, S. Keith, Ballman, Karla V, Tindall, Donald J

    Published in Molecular endocrinology (Baltimore, Md.) (01-04-2009)
    “…Aberrant coregulator expression that occurs during prostate cancer (PCa) progression correlates with poor prognosis and aggressive disease. This has been…”
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  6. 6

    Androgen Induction of the Androgen Receptor Coactivator Four and a Half LIM Domain Protein-2: Evidence for a Role for Serum Response Factor in Prostate Cancer by HEEMERS, Hannelore V, REGAN, Kevin M, DEHM, Scott M, TINDALL, Donald J

    Published in Cancer research (Chicago, Ill.) (01-11-2007)
    “…Androgen receptor (AR) activity is critical for prostate cancer progression. Overexpression of several AR-associated coactivators has been shown to be…”
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  7. 7

    Androgen deprivation increases p300 expression in prostate cancer cells by HEEMERS, Hannelore V, SEBO, Thomas J, DEBES, Jose D, REGAN, Kevin M, RACLAW, Kristin A, MURPHY, Linda M, HOBISCH, Alfred, CULIG, Zoran, TINDALL, Donald J

    Published in Cancer research (Chicago, Ill.) (01-04-2007)
    “…Standard therapy for nonorgan confined prostate cancer aims to block the production or action of androgens. Although initially successful, antiandrogen therapy…”
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  8. 8

    Identification of a Clinically Relevant Androgen-Dependent Gene Signature in Prostate Cancer by HEEMERS, Hannelore V, SCHMIDT, Lucy J, ZHIFU SUN, REGAN, Kevin M, KEITH ANDERSON, S, DUNCAN, Kelly, DAN WANG, SONG LIU, BALLMAN, Karla V, TINDALL, Donald J

    Published in Cancer research (Chicago, Ill.) (01-03-2011)
    “…The androgen receptor (AR) is the principal target for treatment of non-organ-confined prostate cancer (PCa). Androgen deprivation therapies (ADT) directed…”
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  9. 9

    Androgens repress expression of the f-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells by Jiang, Jingting, Pan, Yunqian, Regan, Kevin M., Wu, Changping, Zhang, Xueguang, Tindall, Donald J., Huang, Haojie

    Published in The Prostate (01-02-2012)
    “…BACKGROUND Androgens control homeostasis of the normal prostate and growth of prostate cancer (PCa) through the androgen receptor (AR) by regulating gene…”
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  10. 10

    Higher Prevalence of Babesia microti than Borrelia burgdorferi in Small Mammal Species in Central Pennsylvania, United States by Rocco, Joseph M, Regan, Kevin M, Larkin, Jeffery L, Eichelberger, Charlie, Wisgo, Joseph, Nealen, Paul M, Irani, Vida R

    “…can lead to severe babesiosis in immunosuppressed populations, but due to high numbers of asymptomatic cases, clinical reporting is unable to define its…”
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  11. 11

    CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy by LIYA DING, SHUAI CHEN, JUN ZHANG, SCHMECHEL, Stephen C, CHEVILLE, John C, VAN DEURSEN, Jan, TINDALL, Donald J, HAOJIE HUANG, PING LIU, YUNQIAN PAN, JIAN ZHONG, REGAN, Kevin M, LIGUO WANG, CHUNRONG YU, RIZZARDI, Anthony, LIANG CHENG

    Published in Cancer research (Chicago, Ill.) (01-04-2014)
    “…Despite the high incidence and mortality of prostate cancer, the etiology of this disease is not fully understood. In this study, we develop functional…”
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  12. 12

    Differential regulation of steroid nuclear receptor coregulator expression between normal and neoplastic prostate epithelial cells by Heemers, Hannelore V., Schmidt, Lucy J., Kidd, Emily, Raclaw, Kristin A., Regan, Kevin M., Tindall, Donald J.

    Published in The Prostate (15-06-2010)
    “…BACKGROUND Deregulated androgen receptor (AR) action is critical for prostate cancer (PCa) progression. Aberrant expression of AR‐associated coregulators…”
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  13. 13

    Effects of the 5 alpha-reductase inhibitor dutasteride on gene expression in prostate cancer xenografts by Schmidt, Lucy J., Regan, Kevin M., Anderson, S. Keith, Sun, Zhifu, Ballman, Karla V., Tindall, Donald J.

    Published in The Prostate (01-12-2009)
    “…BACKGROUND In the prostate, androgens play a crucial role in normal and cancerous growth; hence the androgenic pathway has become a target of therapeutic…”
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  14. 14
  15. 15

    Selective Role of an NH sub(2)-Terminal WxxLF Motif for Aberrant Androgen Receptor Activation in Androgen Depletion-Independent Prostate Cancer Cells by Dehm, Scott M, Regan, Kevin M, Schmidt, Lucy J, Tindall, Donald J

    Published in Cancer research (Chicago, Ill.) (01-10-2007)
    “…Systemic prostate cancer therapy requires androgen ablation, which inhibits the production or action of androgens. Prostate cancer ultimately relapses during…”
    Get full text
    Journal Article
  16. 16

    CDK2-dependent phosphorylation of F0X01 as an apoptotic response to DNA damage by HAOJIE HUANG, REGAN, Kevin M, ZHENKUN LOU, JUNJIE CHEN, TINDALL, Donald J

    “…The function of cyclin-dependent kinase 2 (CDK2) is often abolished after DNA damage. The inhibition of CDK2 plays a central role in DNA damage-induced cell…”
    Get full text
    Journal Article