Search Results - "Regan, Kelly"

Neuroepithelial cells and the hypoxia emersion response in the amphibious fish Kryptolebias marmoratus by Regan, Kelly S, Jonz, Michael G, Wright, Patricia A

“…Teleost fish have oxygen-sensitive neuroepithelial cells (NECs) in the gills that appear to mediate physiological responses to hypoxia, but little is known…”
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Retrospective identification of patients with SRRM2‐related neurodevelopmental disorder in a single tertiary children's hospital by Regan‐Fendt, Kelly E., Rippert, Alyssa L., Medne, Livija, Skraban, Cara M., DeJesse, Jeshua, Gray, Christopher, Reichert, Sara L., Staropoli, Nicholas P., Santos, Francis Jeshira Reynoso, Krantz, Ian D., Murrell, Jill R., Izumi, Kosuke

“…SRRM2‐related neurodevelopmental disorder is a recently described genetic diagnosis caused by loss‐of‐function variants in SRRM2. In order to understand the…”
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Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs by Lussier, Yves A, Khodarev, Nikolai N, Regan, Kelly, Corbin, Kimberly, Li, Haiquan, Ganai, Sabha, Khan, Sajid A, Gnerlich, Jennifer L, Gnerlich, Jennifer, Darga, Thomas E, Fan, Hanli, Karpenko, Oleksiy, Paty, Philip B, Posner, Mitchell C, Chmura, Steven J, Hellman, Samuel, Ferguson, Mark K, Weichselbaum, Ralph R

“…Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed…”
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Single sample expression-anchored mechanisms predict survival in head and neck cancer by Yang, Xinan, Regan, Kelly, Huang, Yong, Zhang, Qingbei, Li, Jianrong, Seiwert, Tanguy Y, Cohen, Ezra E W, Xing, H Rosie, Lussier, Yves A

“…Gene expression signatures that are predictive of therapeutic response or prognosis are increasingly useful in clinical care; however, mechanistic (and…”
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Nuclear speckleopathies: developmental disorders caused by variants in genes encoding nuclear speckle proteins by Regan-Fendt, Kelly E., Izumi, Kosuke

“…Nuclear speckles are small, membrane-less organelles that reside within the nucleus. Nuclear speckles serve as a regulatory hub coordinating complex RNA…”
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Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases by Lee, Younghee, Li, Haiquan, Li, Jianrong, Rebman, Ellen, Achour, Ikbel, Regan, Kelly E, Gamazon, Eric R, Chen, James L, Yang, Xinan Holly, Cox, Nancy J, Lussier, Yves A

“…While genome-wide association studies (GWAS) of complex traits have revealed thousands of reproducible genetic associations to date, these loci collectively…”
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Global MicroRNA Profiling for Diagnostic Appraisal of Melanocytic Spitz Tumors by Latchana, Nicholas, MD, MS, Regan, Kelly, BA, Howard, J. Harrison, MD, Aldrink, Jennifer H., MD, Ranalli, Mark A., MD, Peters, Sara B., MD, Zhang, Xiaoli, PhD, Gru, Alejandro, MD, Payne, Philip R.O., PhD, Suarez-Kelly, Lorena P., MD, Carson, William E., MD

“…Abstract Background Melanoma skin cancer remains the leading cause of skin cancer related deaths. Spitz lesions represent a subset of melanocytic skin lesions…”
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Integrative network and transcriptomics-based approach predicts genotype- specific drug combinations for melanoma by Regan, Kelly E, Payne, Philip R O, Li, Fuhai

“…Computational methods for drug combination predictions are needed to identify effective therapies that improve durability and prevent drug resistance in an…”
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Plasma MicroRNA Levels Following Resection of Metastatic Melanoma by Latchana, Nicholas, Abrams, Zachary B, Harrison Howard, J, Regan, Kelly, Jacob, Naduparambil, Fadda, Paolo, Terando, Alicia, Markowitz, Joseph, Agnese, Doreen, Payne, Philip, Carson, William E

“…Melanoma remains the leading cause of skin cancer-related deaths. Surgical resection and adjuvant therapies can result in disease-free intervals for stage III…”
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Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma by Regan-Fendt, Kelly, Li, Ding, Reyes, Ryan, Yu, Lianbo, Wani, Nissar A., Hu, Peng, Jacob, Samson T., Ghoshal, Kalpana, Payne, Philip R.O., Motiwala, Tasneem

“…Objective: Hepatocellular carcinoma (HCC) is frequently diagnosed in patients with late-stage disease who are ineligible for curative surgical therapies. The…”
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MicroRNA profiling of patient plasma for clinical trials using bioinformatics and biostatistical approaches by Markowitz, Joseph, Abrams, Zachary, Jacob, Naduparambil K, Zhang, Xiaoli, Hassani, John N, Latchana, Nicholas, Wei, Lai, Regan, Kelly E, Brooks, Taylor R, Uppati, Sarvani R, Levine, Kala M, Bekaii-Saab, Tanios, Kendra, Kari L, Lesinski, Gregory B, Howard, J Harrison, Olencki, Thomas, Payne, Philip R, Carson, 3rd, William E

“…MicroRNAs (miRNAs) are short noncoding RNAs that function to repress translation of mRNA transcripts and contribute to the development of cancer. We…”
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Correction: Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs by Lussier, Yves A., Khodarev, Nikolai N., Regan, Kelly, Corbin, Kimberly, Li, Haiquan, Ganai, Sabha, Khan, Sajid A., Gnerlich, Jennifer L., Darga, Thomas E., Fan, Hanli, Karpenko, Oleksiy, Paty, Philip B., Posner, Mitchell C., Chmura, Steven J., Hellman, Samuel, Ferguson, Mark K., Weichselbaum, Ralph R.

“…The eighth author's name was spelled incorrectly. (2013) Correction: Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with…”
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Inheritance of cataracts and primary lens luxation in Jack Russell Terriers by Oberbauer, A.M, Holingsworth, S.R, Belanger, J.M, Regan, K.R, Famula, T.R

“…To characterize heritability and mode of inheritance of cataracts and primary lens luxation in Jack Russell Terriers. 872 Jack Russell Terriers from which…”
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Synergy from gene expression and network mining (SynGeNet) method predicts synergistic drug combinations for diverse melanoma genomic subtypes by Regan-Fendt, Kelly E., Xu, Jielin, DiVincenzo, Mallory, Duggan, Megan C., Shakya, Reena, Na, Ryejung, Carson, William E., Payne, Philip R. O., Li, Fuhai

“…Systems biology perspectives are crucial for understanding the pathophysiology of complex diseases, and therefore hold great promise for the discovery of novel…”
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Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs by Oberbauer, Anita M, Belanger, Janelle M, Grossman, Deborah I, Regan, Kelly R, Famula, Thomas R

“…Idiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions…”
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Abstract 1562: Drug repurposing for hepatocellular carcinoma enabled via transcriptomics data from experimental models of sorafenib resistance by Regan, Kelly, Reyes, Ryan, Jacob, Samson, Payne, Philip, Motiwala, Tasneem

“…Hepatocellular carcinoma (HCC) is often diagnosed in patients with advanced disease who are ineligible for curative surgical therapies. Sorafenib is the only…”
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Alterations in patient plasma microRNA expression profiles following resection of metastatic melanoma by Latchana, Nicholas, DiVincenzo, Mallory J., Regan, Kelly, Abrams, Zachary, Zhang, Xiaoli, Jacob, Naduparambil K., Gru, Alejandro A., Fadda, Paolo, Markowitz, Joseph, Howard, J. Harrison, Carson, William E.

“…Background and Objectives MicroRNAs (miRs) are noncoding RNAs that regulate protein translation and melanoma progression. Changes in plasma miR expression…”
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Perceived Benefits and Barriers of a COVID-19 Test to Stay Program in a School District Serving Black or African American People With Low Income, December 2021 by Kamitani, Emiko, Holman, Emily J., Philpott, David, Parasram, Vidisha D., Ruth, Laird J., Onyeuku, Chisom, Carter, Brittani, Gwynn, Eugenia, Beck, Timothy W., Regan, Kelly, Hagler, LaVerne R., Clark, Angela, Shelley, Gene, Thomas, Ebony S.

“…Objectives: Quarantine after exposure to COVID-19 has resulted in substantial loss of in-person learning in schools from prekindergarten through grade 12. Test…”
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System by Regan, Kelly, Moosavinasab, Soheil, Payne, Philip, Lin, Simon

“…The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal…”
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System by Regan, Kelly, Moosavinasab, Soheil, Payne, Philip, Lin, Simon

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