Search Results - "Regan, John W"

Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells by Kitagawa, Kana, Hamaguchi, Ayaka, Fukushima, Keijo, Nakano, Yuki, Regan, John W., Mashimo, Masato, Fujino, Hiromichi

“…Chronic inflammatory bowel disease (IBD), which is characterized by prolonged inflammation of the gastrointestinal tract is associated with an increased risk…”
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Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases by Fujino, Hiromichi, Xu, Wei, Regan, John W

“…Prostaglandin E 2 (PGE 2 ) mediates its physiological effects by interactions with a subfamily of G-protein-coupled receptors known as EP receptors. These…”
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Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products by Wada, Masayuki, DeLong, Cynthia J., Hong, Yu H., Rieke, Caroline J., Song, Inseok, Sidhu, Ranjinder S., Yuan, Chong, Warnock, Mark, Schmaier, Alvin H., Yokoyama, Chieko, Smyth, Emer M., Wilson, Stephen J., FitzGerald, Garret A., Garavito, R. Michael, Sui, De Xin, Regan, John W., Smith, William L.

“…Dietary fish oil containing ω3 highly unsaturated fatty acids has cardioprotective and anti-inflammatory effects. Prostaglandins (PGs) and thromboxanes are…”
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Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2 by Fujino, Hiromichi, Salvi, Sambhitab, Regan, John W

“…The EP2 and EP4 prostanoid receptors are G-protein-coupled receptors whose activation by their endogenous ligand, prostaglandin (PG) E2, stimulates the…”
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The Gαs‐protein‐mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors by Fukushima, Keijo, Senoo, Kanaho, Kurata, Naoki, Regan, John W., Fujino, Hiromichi

“…EP2 and EP4 prostanoid receptors have long been considered to have similar roles, since they are known to couple with Gαs‐protein and activate cAMP‐mediated…”
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Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands by Suganami, Akiko, Fujino, Hiromichi, Okura, Iori, Yanagisawa, Naoki, Sugiyama, Hajime, Regan, John W., Tamura, Yutaka, Murayama, Toshihiko

“…Human D‐type prostanoid (DP) and E‐type prostanoid 2 (EP2) receptors are G protein‐coupled receptors and are regarded as the most closely related receptors…”
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Phosphorylation of Glycogen Synthase Kinase-3 and Stimulation of T-cell Factor Signaling following Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2 by Fujino, Hiromichi, West, Kimberly A., Regan, John W.

“…Recently we have shown that the FPB prostanoid receptor, a G-protein-coupled receptor that couples to Gαq, activates T-cell factor (Tcf)/lymphoid enhancer…”
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Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells by Fujino, Hiromichi, Seira, Naofumi, Kurata, Naoki, Araki, Yumi, Nakamura, Hiroyuki, Regan, John W., Murayama, Toshihiko

“…Approximately two decades have passed since E-type prostanoid 4 (EP4) receptors were cloned, and the signaling pathways mediated by these receptors have since…”
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Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line by Seira, Naofumi, Yanagisawa, Naoki, Suganami, Akiko, Honda, Takuya, Wasai, Makiko, Regan, John W., Fukushima, Keijo, Yamaguchi, Naoto, Tamura, Yutaka, Arai, Takayoshi, Murayama, Toshihiko, Fujino, Hiromichi

“…Increases in the expression of prostaglandin E2 (PGE2) are widely known to be involved in aberrant growth in the early stage of colon cancer development. We…”
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Prostaglandin E₂ regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells by Fujino, Hiromichi, Toyomura, Kaori, Chen, Xiao-bo, Regan, John W, Murayama, Toshihiko

“…An important event in the development of tumors is angiogenesis, or the formation of new blood vessels. Angiogenesis is also known to be involved in tumor cell…”
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Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer? by Fujino, Hiromichi, Regan, John W.

“…The significance of receptor heterogeneity has, in many cases, been unclear, particularly in the case of closely related receptor subtypes that are activated…”
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Heat Release Rate Characterization of NFPA 1403 Compliant Training Fuels by Regan, John W.

“…When using solid fuels for live fire training, NFPA 1403: Standard on Live Fire Training Evolutions requires that the materials be wood based. While the…”
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Toward improved thermal exposure classes for structural firefighters by Weinschenk, Craig, Knight, Holli, Regan, John W

“…In the early 1970s, there was an initial effort to quantify the conditions under which firefighters are expected to perform. Harvey Utech led this endeavor by…”
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A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells by Oyama, Satomi, Fujino, Hiromichi, Yamazaki, Risa, Okura, Iori, Regan, John W., Awata, Atsuko, Arai, Takayoshi, Murayama, Toshihiko

“…•A new indole compound, AWT-489 shows antagonistic effect on DP prostanoid receptors.•AWT-489 inhibited PGD2-induced CD55 expression in LS174T cells.•AWT-489…”
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The induction of S100p expression by the Prostaglandin E2 (PGE2)/EP4 receptor signaling pathway in colon cancer cells by Chandramouli, Anupama, Mercado-Pimentel, Melania E., Hutchinson, Anthony, Gibadulinová, Adriana, Olson, Erik R., Dickinson, Sally, Shañas, Reneé, Davenport, Jennifer, Owens, Janae, Bhattacharyya, Achyut K., Regan, John W., Pastorekova, Silvia, Arumugam, Thiruvengadam, Logsdon, Craig D., Nelson, Mark A.

“…Background: Prostaglandin E2 (PGE2) levels are frequently elevated in colorectal carcinomas. PGE2 is perceived via four transmembrane G protein coupled…”
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EP2 and EP4 prostanoid receptor signaling by Regan, John W

“…The EP(2) and EP(4) prostanoid receptors are two of the four subtypes of receptors for prostaglandin E(2) (PGE(2)). They are in the family of G-protein coupled…”
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Down-regulation of the expression of cyclooxygenase-2 and prostaglandin E 2 by interleukin-4 is mediated via a reduction in the expression of prostanoid EP4 receptors in HCA-7 human colon cancer cells by Kitagawa, Kana, Hamaguchi, Ayaka, Fukushima, Keijo, Nakano, Yuki, Regan, John W, Mashimo, Masato, Fujino, Hiromichi

“…Chronic inflammatory bowel disease (IBD), which is characterized by prolonged inflammation of the gastrointestinal tract is associated with an increased risk…”
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Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells by Kurata, Naoki, Tokashiki, Natsumi, Fukushima, Keijo, Misao, Takaya, Hasuoka, Nanae, Kitagawa, Kana, Mashimo, Masato, Regan, John W., Murayama, Toshihiko, Fujino, Hiromichi

“…Microbiota produce short chain fatty acids (SCFAs), which are known to maintain gut homeostasis, by the fermentation of dietary fiber in the human colon. Among…”
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15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling by Endo, Suzu, Suganami, Akiko, Fukushima, Keijo, Senoo, Kanaho, Araki, Yumi, Regan, John W., Mashimo, Masato, Tamura, Yutaka, Fujino, Hiromichi

“…Prostaglandin E2 (PGE2) is well-known as an endogenous proinflammatory prostanoid synthesized from arachidonic acid by the activation of cyclooxygenase-2. E…”
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FP prostanoid receptor-mediated induction of the expression of early growth response factor-1 by activation of a Ras/Raf/mitogen-activated protein kinase signaling cascade by Xu, Wei, Chou, Chih-Ling, Sun, Haipeng, Fujino, Hiromichi, Chen, Qin M, Regan, John W

“…FP prostanoid receptors are G-protein-coupled receptors whose physiological activator is prostaglandin-F(2alpha) (PGF(2alpha)). PGF(2alpha) has been implicated…”
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