Search Results - "Regan, Daniel P."

The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment by Regan, Daniel P, Coy, Jonathan W, Chahal, Kirti Kandhwal, Chow, Lyndah, Kurihara, Jade N, Guth, Amanda M, Kufareva, Irina, Dow, Steven W

“…Inflammatory monocytes have been shown to play key roles in cancer metastasis through promotion of tumor cell extravasation, growth, and angiogenesis. Monocyte…”
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Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions by Das, Sunetra, Idate, Rupa, Lana, Susan E., Regan, Daniel P., Duval, Dawn L.

“…Soft tissue sarcomas (STS) are a heterogenous group of mesenchymal tumors representing over 50 distinct types with overlapping histological features and…”
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Author Correction: Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions by Das, Sunetra, Idate, Rupa, Lana, Susan E., Regan, Daniel P., Duval, Dawn L.

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Mesenchymal Stem Cells Recruit CCR2 + Monocytes To Suppress Allergic Airway Inflammation by Takeda, Katsuyuki, Webb, Tracy L, Ning, Fangkun, Shiraishi, Yoshiki, Regan, Daniel P, Chow, Lyndah, Smith, Mia J, Ashino, Shigeru, Guth, Amanda M, Hopkins, Sophie, Gelfand, Erwin W, Dow, Steven

“…Mesenchymal stem cells (MSC) exert immune modulatory properties and previous studies demonstrated suppressive effects of MSC treatment in animal models of…”
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Canine oral squamous cell carcinoma as a spontaneous, translational model for radiation and immunology research by Boss, Mary-Keara, Harrison, Lauren G, Gold, Alexandra, Karam, Sana D, Regan, Daniel P

“…Improving outcomes for oral squamous cell carcinoma (OSCC) patients has been hindered by a lack of effective predictive animal models. Spontaneously occurring…”
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NMR-based metabolic profiling of urine, serum, fecal, and pancreatic tissue samples from the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer by Schmahl, Michelle J, Regan, Daniel P, Rivers, Adam C, Joesten, William C, Kennedy, Michael A

“…Pancreatic cancer is the third leading cause of cancer deaths in the United States with more than 53,000 expected to be diagnosed with the disease in 2018. The…”
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Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model by Wheat, William H., Arthun, Erik N., Spencer, John S., Regan, Daniel P., Titus, Richard G., Dow, Steven W.

“…•Vaccination against maxadilan (MAX) protect mice from aggravated Leishmania infection.•Vaccination against MAX increases the number of IFN-γ-producing cells…”
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Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs by Ammons, Dylan T., Hopkins, Leone S., Cronise, Kathryn E., Kurihara, Jade, Regan, Daniel P., Dow, Steven

“…Osteosarcoma (OS) is a heterogeneous, aggressive malignancy of the bone that disproportionally affects children and adolescents. Therapeutic interventions for…”
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Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma by Das, Sunetra, Idate, Rupa, Regan, Daniel P., Fowles, Jared S., Lana, Susan E., Thamm, Douglas H., Gustafson, Daniel L., Duval, Dawn L.

“…Osteosarcoma affects about 2.8% of dogs with cancer, with a one-year survival rate of approximately 45%. The purpose of this study was to characterize mutation…”
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Magnetic Resonance Elastography for Staging Liver Fibrosis in the Oncopig by Gaba, Ron C, Elkhadragy, Lobna, Pennix, Thomas, Schachtschneider, Kyle M, Bolt, Courtni R, Anderson, Aaron, Majumdar, Shreyan, Weber, Denise, Whiteley, Herbert E, Regan, Daniel P, Schook, Lawrence B, Sutton, Bradley P

“…This pilot study investigated the feasibility of using magnetic resonance elastography (MRE) for the non-invasive detection and quantification of liver…”
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The Mouse Model of Pancreatic Cancer Atlas (MMPCA) for classification of pancreatic cancer lesions: A large histological investigation of the Ptf1aCre/+;LSL-KrasG12D/+ transgenic mouse model of pancreatic cancer by Veite-Schmahl, Michelle J, Rivers, Adam C, Regan, Daniel P, Kennedy, Michael A

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the leading forms of cancer related deaths in the United States. With limited treatment options and…”
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Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling by Veite-Schmahl, Michelle J, Regan, Daniel P, Rivers, Adam C, Nowatzke, Joseph F, Kennedy, Michael A

“…We have been investigating the pancreas specific transcription factor, 1a cre-recombinase; lox-stop-lox- Kristen rat sarcoma, glycine to aspartic acid at the…”
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A Large Animal Model for Orthopedic Foot and Ankle Research by Gadomski, Benjamin C, Labus, Kevin M, Stewart, Holly L, Bisazza, Katie T, Nelson, Brad B, Puttlitz, Christian M, McGilvray, Kirk C, Regan, Daniel P, Easley, Jeremiah T

“…Trauma to the soft tissues of the ankle joint distal syndesmosis often leads to syndesmotic instability, resulting in undesired movement of the talus, abnormal…”
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Evaluation of lumbar spinal fusion utilizing recombinant human platelet derived growth factor‐B chain homodimer (rhPDGF‐BB) combined with a bovine collagen/β‐tricalcium phosphate (β‐TCP) matrix in an ovine model by Gadomski, Benjamin C., Labus, Kevin M., Puttlitz, Christian M., McGilvray, Kirk C., Regan, Daniel P., Nelson, Brad, Seim, Howard B., Easley, Jeremiah T.

“…Background context While the clinical effectiveness of recombinant human Platelet Derived Growth Factor‐B chain homodimer combined with collagen and…”
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Canine sarcomas as a surrogate for the human disease by Gustafson, Daniel L., Duval, Dawn L., Regan, Daniel P., Thamm, Douglas H.

“…Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies…”
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Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma by Regan, Daniel P, Chow, Lyndah, Das, Sunetra, Haines, Laurel, Palmer, Eric, Kurihara, Jade N, Coy, Jonathan W, Mathias, Alissa, Thamm, Douglas H, Gustafson, Daniel L, Dow, Steven W

“…There is increasing recognition that progress in immuno-oncology could be accelerated by evaluating immune-based therapies in dogs with spontaneous cancers…”
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Molecular landscape of canine soft tissue sarcoma by Das, Sunetra, Idate, Rupa, Regan, Daniel P., Lana, Susan E., Duval, Dawn L.

“…Canine soft tissue sarcomas (STS) are a heterogenous group of malignant tumors arising from mesenchymal cells of soft tissues. This simplified collective of…”
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Transcriptional regulation of alcohol induced liver fibrosis in a translational porcine hepatocellular carcinoma model by Yasmin, Alvi, Regan, Daniel P., Schook, Lawrence B., Gaba, Ron C., Schachtschneider, Kyle M.

“…Hepatocellular carcinoma (HCC) is the 5th most common and 2nd deadliest cancer worldwide. HCC risk factors include alcohol induced liver cirrhosis, which…”
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Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease by Barnard, Rebecca A, Regan, Daniel P, Hansen, Ryan J, Maycotte, Paola, Thorburn, Andrew, Gustafson, Daniel L

“…The autophagy pathway has been recognized as a mechanism of survival and therapy resistance in cancer, yet the extent of autophagy's function in metastatic…”
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Improved Recovery of Captured Airborne Bacteria and Viruses with Liquid-Coated Air Filters by Regan, Daniel P., Fong, ChunKi, Bond, Avery C. S., Desjardins, Claudia, Hardcastle, Justin, Hung, Shao-Hsiang, Holmes, Andrew P., Schiffman, Jessica D., Maginnis, Melissa S., Howell, Caitlin

“…The COVID-19 pandemic has revealed the importance of the detection of airborne pathogens. Here, we present composite air filters featuring a bioinspired liquid…”
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