Search Results - "Refolo, L."

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology by PAPPOLLA, M. A, BRYANT-THOMAS, WOLOZIN, B, SANO, M, CRUZ-SANCHEZ, F. F, THAL, L. J, PETANCESKA, S. S, REFOLO, L. M, HERBERT, D, PACHECO, J, GARCIA, M. Fabra, MANJON, M, GIRONES, X, HENRY, T. L, MATSUBARA, E, ZAMBON, D

“…Epidemiologic and experimental data suggest that cholesterol may play a role in the pathogenesis of AD. Modulation of cholesterolemia in transgenic animal…”
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A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease by Refolo, L.M., Pappolla, M.A., LaFrancois, J., Malester, B., Schmidt, S.D., Thomas-Bryant, T., Tint, G.S., Wang, R., Mercken, M., Petanceska, S.S., Duff, K.E.

“…Clinical, epidemiological, and laboratory studies suggest that cholesterol may play a role in the pathogenesis of Alzheimer's disease (AD). Transgenic mice…”
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Modulation of Aβ peptides by estrogen in mouse models by Zheng, H., Xu, H., Uljon, S. N., Gross, R., Hardy, K., Gaynor, J., Lafrancois, J., Simpkins, J., Refolo, L. M., Petanceska, S., Wang, R., Duff, K.

“…Clinical studies have shown that estrogen deprivation through menopause is a risk factor in both the initiation and progression of Alzheimer's disease (AD) and…”
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Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes by Duff, K., Knight, H., Refolo, L.M., Sanders, S., Yu, X., Picciano, M., Malester, B., Hutton, M., Adamson, J., Goedert, M., Burki, K., Davies, P.

“…To examine the normal cellular function of tau and its role in pathogenesis, we have created transgenic mice that overexpress a tau transgene derived from a…”
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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 by Duff, Karen, Eckman, Chris, Zehr, Cindy, Yu, Xin, Prada, Cristian-Mihail, Perez-tur, Jordi, Hutton, Mike, Buee, Luc, Harigaya, Yasuo, Yager, Debra, Morgan, David, Gordon, Marcia N, Holcomb, Leigh, Refolo, Lawrence, Zenk, Brenda, Hardy, John, Younkin, Steven

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Statin therapy for Alzheimer's disease: will it work? by Petanceska, Suzana S, DeRosa, Steven, Olm, Vicki, Diaz, Nichole, Sharma, Ali, Thomas-Bryant, Tara, Duff, Karen, Pappolla, Miguel, Refolo, Lorenzo M

“…Disease-modifying therapies are being developed for Alzheimer's disease (AD). These are expected to slow the clinical progression of the disease or delay its…”
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Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model by Refolo, Lorenzo M., Pappolla, Miguel A., Malester, Brian, LaFrancois, John, Bryant-Thomas, Tara, Wang, Rong, Tint, G.Stephen, Sambamurti, Kumar, Duff, Karen

“…Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's disease (AD). However, no direct evidence has been reported linking…”
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Airway inflammation in subjects with gastro‐oesophageal reflux and gastro‐oesophageal reflux‐related asthma by CARPAGNANO, G. E., RESTA, O., VENTURA, M. T., AMORUSO, A. C., GIOIA, G., GILIBERTI, T., REFOLO, L., FOSCHINO‐BARBARO, M. P.

“… Study objectives.  Asthma and gastro‐oesophageal reflux (GER) are both characterized by airway inflammation. Design.  The purposes of this work were (i) to…”
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New directions in neuroprotection: basic mechanisms, molecular targets and treatment strategies by Refolo, L M, Fillit, H M

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A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43) by Eckman, C B, Mehta, N D, Crook, R, Perez-tur, J, Prihar, G, Pfeiffer, E, Graff-Radford, N, Hinder, P, Yager, D, Zenk, B, Refolo, L M, Prada, C M, Younkin, S G, Hutton, M, Hardy, J

“…We report a novel mutation in the amyloid precursor protein gene (APP I716V) which probably leads to familial early onset Alzheimer's disease with an onset age…”
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Cholesterol, oxidative stress, and Alzheimer’s disease: expanding the horizons of pathogenesis by Pappolla, Miguel A, Smith, Mark A, Bryant-Thomas, Tara, Bazan, Nicolas, Petanceska, Suzana, Perry, George, Thal, Leon J, Sano, Mary, Refolo, Lorenzo M

“…Recent epidemiological, clinical, and experimental data suggest that cholesterol may play a role in Alzheimer’s disease (AD). We have recently shown that…”
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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization by Gandhi, Swetal, Refolo, Lorenzo M, Sambamurti, Kumar

“…Alzheimer's disease (AD) is defined by deposits of the 42-residue amyloid-beta peptide (Abeta42) in the brain. Abeta42 is a minor metabolite of the amyloid…”
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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization by Refolo, L M, Sambamurti, K, Efthimiopoulos, S, Pappolla, M A, Robakis, N K

“…Three different treatments (methylamine, colchicine, and 18 degrees C temperature block), known to disrupt normal endocytic internalization, significantly…”
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The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton by Refolo, LM, Wittenberg, IS, Friedrich, VL, Jr, Robakis, NK

“…The amyloid beta-protein (A beta P), the main component of neuritic plaques in Alzheimer's disease (AD), is derived by unknown mechanisms from a family of…”
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Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein by Efthimiopoulos, S, Punj, S, Manolopoulos, V, Pangalos, M, Wang, G P, Refolo, L M, Robakis, N K

“…alpha-Secretase cleaves the full-length Alzheimer's amyloid precursor protein (APP) within the amyloid beta peptide sequence, thus precluding amyloid…”
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Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol by Petanceska, Suzana S, DeRosa, Steven, Sharma, Ali, Diaz, Nichole, Duff, Karen, Tint, Steven G, Refolo, Lorenzo M, Pappolla, Miguel

“…Apolipoprotein E (ApoE) influences the risk of late onset Alzheimer's disease (AD) in an isoform-dependent manner, such that the presence of the apoE epsilon4…”
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Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures by Refolo, L M, Salton, S R, Anderson, J P, Mehta, P, Robakis, N K

“…Antisera against specific sites of the Alzheimer beta Amyloid protein precursor (beta APP) were used to study the effects of nerve and epidermal growth factors…”
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Antisense-Induced Reduction of Presenilin 1 Expression Selectively Increases the Production of Amyloid beta 42 in Transfected Cells by Refolo, L M, Eckman, C, Prada, C-M, Yager, D, Sambamurti, K, Mehta, N, Hardy, J, Younkin, S G

“…Autosomal dominant mutations in the presenilin 1 (PS1) gene are associated with familial, early-onset Alzheimer's disease. Although the pathogenic mechanism of…”
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Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein by Efthimiopoulos, S, Felsenstein, K M, Sambamurti, K, Robakis, N K, Refolo, L M

“…Phorbol esters (PDBu) stimulate alpha-secretase cleavage and secretion of the Alzheimer amyloid precursor protein (APP). To determine whether any cytoplasmic…”
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The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia by Berkenbosch, F, Refolo, L M, Friedrich, Jr, V L, Casper, D, Blum, M, Robakis, N K

“…The production of beta-amyloid precursor protein (beta APP) by primary mixed glial cell cultures from cerebral cortex of 2-3 day postnatal rats was examined by…”
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