Search Results - "Reff, Mitchell E."

Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response by Dong, Jianying, Demarest, Stephen J, Sereno, Arlene, Tamraz, Susan, Langley, Emma, Doern, Adam, Snipas, Tracey, Perron, Keli, Joseph, Ingrid, Glaser, Scott M, Ho, Steffan N, Reff, Mitchell E, Hariharan, Kandasamy

“…The insulin-like growth factor-I receptor (IGF-IR) is a cell surface receptor tyrosine kinase that mediates cell survival signaling and supports tumor…”
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Conserved amino acid networks involved in antibody variable domain interactions by Wang, Norman, Smith, William F., Miller, Brian R., Aivazian, Dikran, Lugovskoy, Alexey A., Reff, Mitchell E., Glaser, Scott M., Croner, Lisa J., Demarest, Stephen J.

“…Engineered antibodies are a large and growing class of protein therapeutics comprising both marketed products and many molecules in clinical trials in various…”
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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity by Dong, Jianying, Sereno, Arlene, Aivazian, Dikran, Langley, Emma, Miller, Brian R., Snyder, William B, Chan, Eric, Cantele, Matt, Morena, Ronald, Joseph, Ingrid B.J.K., Boccia, Antonio, Virata, Cyrus, Gamez, James, Yco, Grace, Favis, Michael, Wu, Xiufeng, Graff, Christilyn P., Wang, Qin, Rohde, Ellen, Rennard, Rachel, Berquist, Lisa, Huang, Flora, Zhang, Ying, Gao, Sharon X., Ho, Steffan N., Demarest, Stephen J., Reff, Mitchell E., Hariharan, Kandasamy, Glaser, Scott M.

“…The epidermal growth factor receptor (EGFR) and the type I insulin-like growth factor receptor (IGF-1R) are two cell surface receptor tyrosine kinases known to…”
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Novel Antibody Hinge Regions for Efficient Production of CH2 Domain-deleted Antibodies by Glaser, Scott M., Hughes, Ina E., Hopp, Jennifer R., Hathaway, Karen, Perret, Daniel, Reff, Mitchell E.

“…HuCC49ΔCH2 is a heavy chain constant domain 2 domain-deleted antibody under development as a radioimmunotherapeutic for treating carcinomas overexpressing the…”
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Future of monoclonal antibodies in the treatment of hematologic malignancies by Reff, Mitchell E, Hariharan, Kandasamy, Braslawsky, Gary

“…The approval of monoclonal antibodies (MAbs) as antibody-targeted therapy in the management of patients with hematologic malignancies has led to new treatment…”
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Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties: IMPLICATIONS FOR MECHANISM OF ACTION IN VIVO by Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L, Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S, Rennard, Rachel, Graff, Christilyn P, Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N, Reff, Mitchell E, Glaser, Scott M, Dong, Jianying, Demarest, Stephen J, Hariharan, Kandasamy

“…Therapeutic antibodies directed against the type 1 insulin-like growth factor receptor (IGF-1R) have recently gained significant momentum in the clinic because…”
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Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties by Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L., Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S., Rennard, Rachel, Graff, Christilyn P., Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N., Reff, Mitchell E., Glaser, Scott M., Dong, Jianying, Demarest, Stephen J., Hariharan, Kandasamy

“…Therapeutic antibodies directed against the type 1 insulin-like growth factor receptor (IGF-1R) have recently gained significant momentum in the clinic because…”
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Anti-CD23 monoclonal antibody inhibits germline Cε transcription in B cells by Yabuuchi, Shingo, Nakamura, Takehiko, Kloetzer, William S, Reff, Mitchell E

“…A chimeric macaque/human (PRIMATIZED®) anti-CD23 antibody, p6G5G1, demonstrated a strong inhibitory effect on IL-4- and anti-CD40 antibody-stimulated IgE…”
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Production and Characterization of a Set of Mouse-Human Chimeric Immunoglobulin G (IgG) Subclass and IgA Monoclonal Antibodies with Identical Variable Regions Specific forPseudomonas aeruginosa Serogroup O6 Lipopolysaccharide by Preston, Michael J., Gerçeker, A. Alev, Reff, Mitchell E., Pier, Gerald B.

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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In vitro IgE inhibition in B cells by anti-CD23 monoclonal antibodies is functionally dependent on the immunoglobulin Fc domain by Nakamura, Takehiko, Kloetzer, William S, Brams, Peter, Hariharan, Kandasamy, Chamat, Soulaima, Cao, Xianjun, LaBarre, Michael J, Chinn, Paul C, Morena, Ron A, Shestowsky, William S, Li, Yan-Ping, Chen, Agnes, Reff, Mitchell E

“…CD23, the low affinity receptor for IgE (FcεRII), is involved in regulation of IgE synthesis by B-lymphocytes. Five monoclonal antibodies to human CD23 were…”
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Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20 by REFF, M. E, CHAMBERS, K. S, CHINN, P. C, LEONARD, J. E, RAAB, R, NEWMANN, R. A, HANNA, N, ANDERSON, D. R

“…Murine monoclonal antibody 2B8 specifically recognizes the CD20 phosphoprotein expressed on the surface of normal B lymphocytes and B-cell lymphomas. The…”
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A review of modifications to recombinant antibodies: attempt to increase efficacy in oncology applications by Reff, Mitchell E., Heard, Cheryl

“…Although monoclonal antibodies have high specificity, their usefulness in the clinic, especially against solid tumors, has been limited. This arises in part…”
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Novel Antibody Hinge Regions for Efficient Production of C sub(H)2 Domain-deleted Antibodies by Glaser, Scott M, Hughes, Ina E, Hopp, Jennifer R, Hathaway, Karen, Perret, Daniel, Reff, Mitchell E

“…HuCC49 Delta CH2 is a heavy chain constant domain 2 domain-deleted antibody under development as a radioimmunotherapeutic for treating carcinomas…”
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A review of modifications to recombinant antibodies : attempt to increase efficacy in oncology applications : Monoclonal antibodies and cancer by REFF, Mitchell E, HEARD, Cheryl

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Generation, and Characterization of Two Tetravalent CH2 Domain-Deleted CC49 Mabs by Wu, Xiufeng, Hopp, Jennifer, Perret, Daniel, Chung, Julie, Reff, Mitchell E, Glaser, Scott M

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Anti-CD23 monoclonal antibody inhibits germline Cepsilon transcription in B cells by Yabuuchi, Shingo, Nakamura, Takehiko, Kloetzer, William S, Reff, Mitchell E

“…A chimeric macaque/human (PRIMATIZED) anti-CD23 antibody, p6G5G1, demonstrated a strong inhibitory effect on IL-4 and anti-CD40 antibody-stimulated IgE…”
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Production, Characterization, and Biodistribution Studies of a Novel Hinge Engineered Domain-Deleted CC49 Monoclonal Antibody by Hughes, Ina, Chinn, Paul, Kazules, Tim, Morena, Ron, Perret, Daniel, Hopp, Jennifer, Hathaway, Karen, Barnett, Richard S, Reff, Mitchell E, Glaser, Scott M

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High-level production of recombinant immunoglobulins in mammalian cells by Reff, M E

“…Successful high-level expression of recombinant immunoglobulins has now been reported in several different types of mammalian cells. This has been achieved…”
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Production and characterization of a set of mouse-human chimeric immunoglobulin G (IgG) subclass and IgA monoclonal antibodies with identical variable regions specific for Pseudomonas aeruginosa serogroup O6 lipopolysaccharide by PRESTON, M. J, GERCEKER, A. A, REFF, M. E, PIER, G. B

“…The heavy- and light-chain variable regions from a murine monoclonal antibody that recognize Pseudomonas aeruginosa serogroup O6 lipopolysaccharide (LPS) were…”
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Integrin-dependent tyrosine phosphorylation and growth regulation by Vav by Yron, I, Deckert, M, Reff, M E, Munshi, A, Schwartz, M A, Altman, A

“…The proto-oncogene product p95Vav (Vav) undergoes rapid phosphorylation on tyrosine following stimulation of the T or B cell antigen receptor, and in response…”
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