Search Results - "Reeves, Philip J."

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy by Athanasiou, Dimitra, Aguila, Monica, Bellingham, James, Li, Wenwen, McCulley, Caroline, Reeves, Philip J., Cheetham, Michael E.

“…Inherited mutations in the rod visual pigment, rhodopsin, cause the degenerative blinding condition, retinitis pigmentosa (RP). Over 150 different mutations in…”
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Bulk fatigue induced by surface reconstruction in layered Ni-rich cathodes for Li-ion batteries by Xu, Chao, Märker, Katharina, Lee, Juhan, Mahadevegowda, Amoghavarsha, Reeves, Philip J., Day, Sarah J., Groh, Matthias F., Emge, Steffen P., Ducati, Caterina, Layla Mehdi, B., Tang, Chiu C., Grey, Clare P.

“…Ni-rich layered cathode materials are among the most promising candidates for high-energy-density Li-ion batteries, yet their degradation mechanisms are still…”
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Intrinsic Kinetic Limitations in Substituted Lithium-Layered Transition-Metal Oxide Electrodes by Grenier, Antonin, Reeves, Philip J, Liu, Hao, Seymour, Ieuan D, Märker, Katharina, Wiaderek, Kamila M, Chupas, Peter J, Grey, Clare P, Chapman, Karena W

“…Substituted Li-layered transition-metal oxide (LTMO) electrodes such as Li x Ni y Mn z Co1–y–z O2 (NMC) and Li x Ni y Co1–y–z Al z O2 (NCA) show reduced first…”
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Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation by Kimata, Naoki, Pope, Andreyah, Eilers, Markus, Opefi, Chikwado A., Ziliox, Martine, Hirshfeld, Amiram, Zaitseva, Ekaterina, Vogel, Reiner, Sheves, Mordechai, Reeves, Philip J., Smith, Steven O.

“…The 11- cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsin and isomerizes to the all- trans configuration following…”
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Structural Origins of Voltage Hysteresis in the Na-Ion Cathode P2–Na0.67[Mg0.28Mn0.72]O2: A Combined Spectroscopic and Density Functional Theory Study by Bassey, Euan N, Reeves, Philip J, Jones, Michael A, Lee, Jeongjae, Seymour, Ieuan D, Cibin, Giannantonio, Grey, Clare P

“…P2-layered sodium-ion battery (NIB) cathodes are a promising class of Na-ion electrode materials with high Na+ mobility and relatively high capacities. In this…”
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Designer Short Peptide Surfactants Stabilize G Protein-Coupled Receptor Bovine Rhodopsin by Zhao, Xiaojun, Nagai, Yusuke, Reeves, Philip J., Kiley, Patrick, Khorana, H. Gobind, Zhang, Shuguang

“…Membrane proteins play vital roles in every aspect of cellular activities. To study diverse membrane proteins, it is crucial to select the right surfactants to…”
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Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration by Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A, South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M, Kanuga, Naheed, Mackenzie, Francesca E, Dubis, Adam M, Georgiadis, Anastasios, Graca, Anna B, Pearson, Rachael A, Ali, Robin R, Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y, Reeves, Philip J, Cheetham, Michael E

“…Protein misfolding caused by inherited mutations leads to loss of protein function and potentially toxic 'gain of function', such as the dominant P23H…”
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Phase Behavior during Electrochemical Cycling of Ni‐Rich Cathode Materials for Li‐Ion Batteries by Xu, Chao, Reeves, Philip J., Jacquet, Quentin, Grey, Clare P.

“…Although layered lithium nickel‐rich oxides have become the state‐of‐the‐art cathode materials for lithium‐ion batteries in electric vehicle (EV) applications,…”
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G Protein-Coupled Receptors Contain Two Conserved Packing Clusters by Sanchez-Reyes, Omar B., Cooke, Aidan L.G., Tranter, Dale B., Rashid, Dawood, Eilers, Markus, Reeves, Philip J., Smith, Steven O.

“…G protein-coupled receptors (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wide range of extracellular signals. An analysis…”
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The Molecular Switching Mechanism at the Conserved D(E)RY Motif in Class-A GPCRs by Sandoval, Angelica, Eichler, Stefanie, Madathil, Sineej, Reeves, Philip J., Fahmy, Karim, Böckmann, Rainer A.

“…The disruption of ionic and H-bond interactions between the cytosolic ends of transmembrane helices TM3 and TM6 of class-A (rhodopsin-like) G protein-coupled…”
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Structure and Function in Rhodopsin: High-Level Expression of Rhodopsin with Restricted and Homogeneous N-Glycosylation by a Tetracycline-Inducible N-Acetylglucosaminyltransferase I-Negative HEK293S Stable Mammalian Cell Line by Reeves, Philip J., Callewaert, Nico, Contreras, Roland, Khorana, H. Gobind

“…An HEK293S cell line resistant to ricin was prepared by mutagenesis by using ethyl methanesulfonate. It was shown to lack N-acetylglucosaminyltransferase I…”
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Free backbone carbonyls mediate rhodopsin activation by Kimata, Naoki, Pope, Andreyah, Sanchez-Reyes, Omar B, Eilers, Markus, Opefi, Chikwado A, Ziliox, Martine, Reeves, Philip J, Smith, Steven O

“…Solid-state NMR analyses reveal that the free backbone carbonyl groups associated with proline residues in the transmembrane helices play a key role in…”
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Highly conserved tyrosine stabilizes the active state of rhodopsin by Goncalves, Joseph A., South, Kieron, Ahuja, Shivani, Zaitseva, Ekaterina, Opefi, Chikwado A., Eilers, Markus, Vogel, Reiner, Reeves, Philip J., Smith, Steven O., Henderson, Richard

“…Light-induced isomerization of the 11-cis-retinal chromophore in the visual pigment rhodopsin triggers displacement of the second extracellular loop (EL2) and…”
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Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy by Pope, Andreyah, Eilers, Markus, Reeves, Philip J., Smith, Steven O.

“…Rhodopsin is a classical two-state G protein-coupled receptor (GPCR). In the dark, its 11-cis retinal chromophore serves as an inverse agonist to lock the…”
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Light-Driven Activation of β2-Adrenergic Receptor Signaling by a Chimeric Rhodopsin Containing the β2-Adrenergic Receptor Cytoplasmic Loops by Kim, Jong-Myoung, Hwa, John, Garriga, Pere, Reeves, Philip J, RajBhandary, Uttam L, Khorana, H. Gobind

“…Structure−function studies of rhodopsin indicate that both intradiscal and transmembrane (TM) domains are required for retinal binding and subsequent…”
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Location of the Retinal Chromophore in the Activated State of Rhodopsin by Ahuja, Shivani, Crocker, Evan, Eilers, Markus, Hornak, Viktor, Hirshfeld, Amiram, Ziliox, Martine, Syrett, Natalie, Reeves, Philip J., Khorana, H.Gobind, Sheves, Mordechai, Smith, Steven O.

“…Rhodopsin is a highly specialized G protein-coupled receptor (GPCR) that is activated by the rapid photochemical isomerization of its covalently bound…”
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Evolution of Structure and Lithium Dynamics in LiNi0.8Mn0.1Co0.1O2 (NMC811) Cathodes during Electrochemical Cycling by Märker, Katharina, Reeves, Philip J, Xu, Chao, Griffith, Kent J, Grey, Clare P

“…The nickel-rich layered oxide LiNi0.8Mn0.1Co0.1O2 (NMC811) is a promising future cathode material for lithium-ion batteries in electric vehicles due to its…”
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Light Activation of Rhodopsin: Insights from Molecular Dynamics Simulations Guided by Solid-State NMR Distance Restraints by Hornak, Viktor, Ahuja, Shivani, Eilers, Markus, Goncalves, Joseph A., Sheves, Mordechai, Reeves, Philip J., Smith, Steven O.

“…Structural restraints provided by solid-state NMR measurements of the metarhodopsin II intermediate are combined with molecular dynamics simulations to help…”
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Electrochemical Performance of Nanosized Disordered LiVOPO4 by Shi, Yong, Zhou, Hui, Seymour, Ieuan D, Britto, Sylvia, Rana, Jatinkumar, Wangoh, Linda W, Huang, Yiqing, Yin, Qiyue, Reeves, Philip J, Zuba, Mateusz, Chung, Youngmin, Omenya, Fredrick, Chernova, Natasha A, Zhou, Guangwen, Piper, Louis F. J, Grey, Clare P, Whittingham, M. Stanley

“…ε-LiVOPO4 is a promising multielectron cathode material for Li-ion batteries that can accommodate two electrons per vanadium, leading to higher energy…”
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Structure and Function in Rhodopsin: A Tetracycline-Inducible System in Stable Mammalian Cell Lines for High-Level Expression of Opsin Mutants by Reeves, Philip J., Kim, Jong-Myoung, Khorana, H. Gobind

“…Tetracycline-inducible HEK293S stable cell lines have been prepared that express high levels (up to 10 mg/liter) of WT opsin and its mutants only in response…”
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