Search Results - "Reeves, Erica K. M."
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VBP15, a Novel Anti-Inflammatory, is Effective at Reducing the Severity of Murine Experimental Autoimmune Encephalomyelitis
Published in Cellular and molecular neurobiology (01-04-2015)“…Multiple sclerosis is a chronic disease of the central nervous system characterized by an autoimmune inflammatory reaction that leads to axonal demyelination…”
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VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice
Published in PloS one (07-05-2013)“…Asthma is a chronic inflammatory condition of the lower respiratory tract associated with airway hyperreactivity and mucus obstruction in which a majority of…”
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Proteomic profiling of glucocorticoid-exposed myogenic cells: Time series assessment of protein translocation and transcription of inactive mRNAs
Published in Proteome science (30-07-2009)“…Prednisone, one of the most highly prescribed drugs, has well characterized effects on gene transcription mediated by the glucocorticoid receptor. These…”
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VBP15, a novel anti‐inflammatory and membrane‐stabilizer, improves muscular dystrophy without side effects
Published in EMBO molecular medicine (01-10-2013)“…Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches of the plasma membrane and chronic inflammation in Duchenne…”
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VBP15: Preclinical characterization of a novel anti-inflammatory delta 9,11 steroid
Published in Bioorganic & medicinal chemistry (15-04-2013)“…Δ9,11 modifications of glucocorticoids (21-aminosteroids) have been developed as drugs for protection against cell damage (lipid peroxidation; lazaroids) and…”
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Δ-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects
Published in The Journal of pharmacology and experimental therapeutics (01-10-2012)“…Glucocorticoids are standard of care for many inflammatory conditions, but chronic use is associated with a broad array of side effects. This has led to a…”
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Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium
Published in American journal of respiratory cell and molecular biology (01-09-2014)“…We recently proposed that mitotic asynchrony in repairing tissue may underlie chronic inflammation and fibrosis, where immune cell infiltration is secondary to…”
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Glucocorticoid analogues: potential therapeutic alternatives for treating inflammatory muscle diseases
Published in Endocrine, metabolic & immune disorders drug targets (01-03-2012)“…Glucocorticoids (GCs) have been prescribed to treat a variety of diseases, including inflammatory myopathies and Duchenne muscular dystrophy for over 50 years…”
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Mitotic Asynchrony Induces Transforming Growth Factor-b1 Secretion from Airway Epithelium
Published in American journal of respiratory cell and molecular biology (01-09-2014)“…In this paper, the authors recently proposed that mitotic asynchrony in repairing tissue may underlie chronic inflammation and fibrosis, where immune cell…”
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