Search Results - "Reeve, J G"

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance by REEVE, J. G, XIONG, J, MORGAN, J, BLEEHEN, N. M

“…As a first step towards elucidating the potential role(s) of bcl-2 and bcl-2-related genes in lung tumorigenesis and therapeutic responsiveness, the expression…”
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Neuroendocrine differentiation and clinical behaviour in non-small cell lung tumours by SUNDARESAN, V, REEVE, J. G, STENNING, S, STEWART, S, BLEEHEN, N. M

“…The present study examines the relationship between neuroendocrine (NE) differentiation and the clinical behaviour of non-small cell lung cancer (NSCLC)…”
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Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors by REEVE, J. G, MORGAN, J, SCHWANDER, J, BLEEHEN, N. M

“…The insulin-like growth factors (IGFs) have been implicated in the autocrine and/or paracrine growth of a number of tumor types, including lung tumors…”
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Expression of insulinlike growth factor (IGF) and IGF-binding protein genes in human lung tumor cell lines by Reeve, J G, Brinkman, A, Hughes, S, Mitchell, J, Schwander, J, Bleehen, N M

“…The presence of multiple, low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor cell-conditioned medium and lung cancer patient…”
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Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours by REEVE, J. G, PAYNE, J. A, BLEEHEN, N. M

“…The production of insulin-like growth factor I (IGF-I) and IGF-I binding proteins (BPs) by human lung tumour cell lines in vitro has been examined and the…”
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Amplification and expression of mdr1 gene in a multidrug resistant variant of small cell lung cancer cell line NCI-H69 by REEVE, J. G, RABBITTS, P. H, TWENTYMAN, P. R

“…Amplification and expression of the mdr1 gene encoding P-glycoprotein have been studied in H69/LX4 a multidrug resistant variant (MDR) of small cell lung…”
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Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin) by TWENTYMAN, P. R, REEVE, J. G, KOCH, G, WRIGHT, K. A

“…The relationships between resistance to adriamycin, vincristine, colchicine and etopside, expression of P-glycoprotein and CP22 (sorcin), and resistance…”
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Non-P-glycoprotein-mediated multidrug resistance with reduced EGF receptor expression in a human large cell lung cancer cell line by REEVE, J. G, RABBITTS, P. H, TWENTYMAN, P. R

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Characterization of ligand binding and processing by gastrin-releasing peptide receptors in a small-cell lung cancer cell line by CARDONA, C, BLEEHEN, N. M, REEVE, J. G

“…The ligand-binding properties of the gastrin-releasing peptide (GRP) receptor and the cellular processing of GRP have been studied in the small-cell lung…”
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Insulin-like growth-factor-binding protein gene expression and protein production by human tumour cell lines by Reeve, J G, Kirby, L B, Brinkman, A, Hughes, S A, Schwander, J, Bleehen, N M

“…The secretion of insulin-like growth-factor-binding proteins (IGFBPs) and expression of the genes encoding IGFBP-1, IGFBP-2 and IGFBP-3 have been studied in a…”
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Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma) by BAILLIE-JOHNSON, H, TWENTYMAN, P. R, FOX, N. E, WALLS, G. A, WORKMAN, P, WATSON, J. V, JOHNSON, N, REEVE, J. G, BLEEHEN, N. M

“…Tissue samples from 59 patients with lung cancer have been used to establish cell lines in culture. The primary diagnosis was small cell carcinoma in all…”
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[D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P induces apoptosis in lung cancer cell lines in vitro by Reeve, J G, Bleehen, N M

“…The broad spectrum antagonist [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P has been shown previously to inhibit the growth of small cell lung cancer cells…”
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Insulin-like growth factor (IGF) and IGF binding proteins in growth hormone dysregulation and abnormal glucose tolerance in small cell lung cancer patients by Reeve, J.G., Morgan, J., Clark, P.M.S., Bleehen, N.M.

“…Growth hormone (GH) regulation, glucose tolerance and serum concentrations of insulin-like growth factor (IGF) and IGF binding proteins (IGFBP) have been…”
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Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines by CARDONA, C, RABBITTS, P. H, SPINDEL, E. R, GHATEI, M. A, BLEEHEN, N. M, BLOOM, S. R, REEVE, J. G

“…Gastrin-releasing peptide (GRP), a mammalian bombesin-like peptide, has been shown to be an important autocrine growth factor for small cell lung cancer…”
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Neuron specific enolase expression in carcinoma of the lung by REEVE, J. G, STEWART, J, WATSON, J. V, WULFRANK, D, TWENTYMAN, P. R, BLEEHEN, N. M

“…The value of neuron specific enolase (NSE) immunoreactivity as a marker for small cell lung cancer (SLC) has been assessed using a monoclonal antibody (MCAB)…”
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Neurotensin in human small cell lung carcinoma by GOEDERT, M, REEVE, J. G, EMSON, P. C, BLEEHEN, N. M

“…High levels of neurotensin-like immunoreactivity were found in human small cell lung carcinoma lines. No immunoreactivity was present in non-small cell…”
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Flow cytometric and immunohistochemical analysis of p62c-myc oncoprotein in the bronchial epithelium of lung cancer patients by Sundaresan, V, Reeve, J G, Wilson, B, Bleehen, N M, Watson, J V

“…The expression of p62c-myc in bronchial resection lines (BRLs) from lung cancer and control patients, has been examined by immunohistochemistry and parallel…”
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Collateral resistance to verapamil in multidrug-resistant mouse tumor cells by Reeve, J G, Wright, K A, Rabbitts, P H, Twentyman, P R, Koch, G

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Evidence that multidrug resistance in Chinese hamster ovary cells is associated with alterations in the endoplasmic reticulum by REEVE, J. G, KOCH, G. L. E, TWENTYMAN, P. R

“…Multidrug resistance (MDR) in animal and human cell lines is often associated with a reduction in cellular accumulation of the drugs concerned. The present…”
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Patterns of cross-sensitivity in the responses of clonal subpopulations isolated from the RIF-1 mouse sarcoma to selected nitrosoureas and nitrogen mustards by REEVE, J. G, WRIGHT, K. A, WORKMAN, P

“…The response of clonal subpopulations isolated from the RIF-1 mouse sarcoma to melphalan treatment is independent of cell ploidy, whereas a clear relationship…”
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