Search Results - "Reeve, Helen L."

O2 Sensing Is Preserved in Mice Lacking the gp91 Phox Subunit of NADPH Oxidase by Archer, Stephen L., Reeve, Helen L., Michelakis, Evangelos, Puttagunta, Lakshmi, Waite, Ross, Nelson, Daniel P., Dinauer, Mary C., Weir, E. Kenneth

“…The rapid response to hypoxia in the pulmonary artery (PA), carotid body, and ductus arteriosus is partially mediated by O2-responsive K+ channels. K+ channels…”
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Worldwide experience with a totally subcutaneous implantable defibrillator: early results from the EFFORTLESS S-ICD Registry by Lambiase, Pier D, Barr, Craig, Theuns, Dominic A M J, Knops, Reinoud, Neuzil, Petr, Johansen, Jens Brock, Hood, Margaret, Pedersen, Susanne, Kääb, Stefan, Murgatroyd, Francis, Reeve, Helen L, Carter, Nathan, Boersma, Lucas

“…The totally subcutaneous implantable-defibrillator (S-ICD) is a new alternative to the conventional transvenous ICD system to minimize intravascular lead…”
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Differential Distribution of Electrophysiologically Distinct Myocytes in Conduit and Resistance Arteries Determines Their Response to Nitric Oxide and Hypoxia by Archer, Stephen L, Huang, James, Reeve, Helen L, Hampl, Vaclav, Tolarova, Simona, Michelakis, Evangelos, Weir, E. Kenneth

“…The cellular mechanisms that determine differences in reactivity of arteries of varying size and origin are unknown. We evaluated the hypothesis that there is…”
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Redox control of oxygen sensing in the rabbit ductus arteriosus by Reeve, Helen L., Tolarova, Simona, Nelson, Daniel P., Archer, Stephen, Weir, E. Kenneth

“…How the ductus arteriosus (DA) closes at birth remains unclear. Inhibition of O 2 -sensitive K + channels may initiate the closure but the sensor mechanism is…”
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Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction by KENNETH WEIR, E, REEVE, H. L, HUANG, J. M. C, MICHELAKIS, E, NELSON, D. P, HAMPL, V, ARCHER, S. L

“…The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. More recently, pulmonary…”
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Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine by Hong, Zhigang, Olschewski, Andrea, Reeve, Helen L, Nelson, Daniel P, Hong, Fangxiao, Weir, E Kenneth

“…The anorectic agent dexfenfluramine (dex) causes the development of primary pulmonary hypertension in susceptible patients by an unknown mechanism. We compared…”
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A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension by Weir, E K, Reeve, H L, Johnson, G, Michelakis, E D, Nelson, D P, Archer, S L

“…Plasma serotonin levels are markedly elevated in patients with primary pulmonary hypertension (PPH) and platelet levels of serotonin are low. Furthermore,…”
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Oxygen Causes Fetal Pulmonary Vasodilation through Activation of a Calcium-Dependent Potassium Channel by Cornfield, David N., Reeve, Helen L., Tolarova, Simona, Weir, E. Kenneth, Archer, Stephen

“…At birth, pulmonary vasodilation occurs as air-breathing life begins. The mechanism of O2-induced pulmonary vasodilation is unknown. We proposed that O2 causes…”
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Redox signaling in oxygen sensing by vessels by Weir, E.Kenneth, Hong, Zhigang, Porter, Valerie A, Reeve, Helen L

“…In response to the increase in oxygen tension at birth, the resistance pulmonary arteries dilate, while the ductus arteriosus constricts. Although modulated by…”
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Voltage-gated K(+)-channel activity in ovine pulmonary vasculature is developmentally regulated by Cornfield, D N, Saqueton, C B, Porter, V A, Herron, J, Resnik, E, Haddad, I Y, Reeve, H L

“…To examine mechanisms underlying developmental changes in pulmonary vascular tone, we tested the hypotheses that 1) maturation-related changes in the ability…”
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Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated by Porter, V A, Reeve, H L, Cornfield, D N

“…To study developmental changes in intracellular calcium handling in pulmonary artery smooth muscle cells (PASMCs), cells were isolated from distal and proximal…”
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Potassium channel diversity in vascular smooth muscle cells by Michelakis, E D, Reeve, H L, Huang, J M, Tolarova, S, Nelson, D P, Weir, E K, Archer, S L

“…Several recent observations suggest that the vascular medium is a mosaic of functionally and morphologically unique cell types. This diversity includes…”
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Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology by Reeve, H L, Nelson, D P, Archer, S L, Weir, E K

“…The anorexic agents dexfenfluramine and fenfluramine plus phentermine have been associated with outbreaks of pulmonary hypertension. The fenfluramines release…”
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Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells by Michelakis, E D, Weir, E K, Nelson, D P, Reeve, H L, Tolarova, S, Archer, S L

“…Appetite suppressants, such as dexfenfluramine (dex), are associated with primary pulmonary hypertension, valvular heart disease, and systemic vascular…”
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Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture by Weir, E K, Reeve, H L, Peterson, D A, Michelakis, E D, Nelson, D P, Archer, S L

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Calcium channel currents in undifferentiated human neuroblastoma (SH-SY5Y) cells: actions and possible interactions of dihydropyridines and omega-conotoxin by Reeve, H L, Vaughan, P F, Peers, C

“…Ca2+ channel currents were recorded in undifferentiated human neuroblastoma (SH-SY5Y) cells with the whole-cell patch-clamp technique, using 10 mM Ba2+ as…”
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Triple‐bonded unsaturated fatty acids are redox active compounds by Peterson, Douglas A., Reeve, Helen L., Nelson, Daniel, Archer, Stephen L., Weir, E. Kenneth

“…Unsaturated fatty acids with triple bonds are used as inhibitors of unsaturated fatty acid metabolism or cytochrome P450 reactions because they are believed to…”
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The effect of barium on [3H]noradrenalin release from the human neuroblastoma SH-SY5Y by Vaughan, P F, Kaye, D F, Ball, S G, Reeve, H L, Peers, C

“…Replacement of Ca2+ with Ba2+ in HEPES-buffered saline stimulated [3H]noradrenalin release in the human neuroblastoma clone SH-SY5Y by up to 20% of the cell…”
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O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase by Archer, Stephen L., Reeve, Helen L., Michelakis, Evangelos, Puttagunta, Lakshmi, Waite, Ross, Nelson, Daniel P., Dinauer, Mary C., Weir, E. Kenneth

“…The rapid response to hypoxia in the pulmonary artery (PA), carotid body, and ductus arteriosus is partially mediated by O 2 -responsive K + channels. K +…”
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Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes by Archer, S L, Souil, E, Dinh-Xuan, A T, Schremmer, B, Mercier, J C, El Yaagoubi, A, Nguyen-Huu, L, Reeve, H L, Hampl, V

“…Hypoxia initiates pulmonary vasoconstriction (HPV) by inhibiting one or more voltage-gated potassium channels (Kv) in the pulmonary artery smooth muscle cells…”
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