Search Results - "Reeve, H L"

Alterations in a redox oxygen sensing mechanism in chronic hypoxia by Reeve, H. L, Michelakis, E, Nelson, D. P, Weir, E. K, Archer, S. L

“…Departments of 1  Medicine and 2  Physiology, University of Minnesota, Minneapolis 55455; 3  Department of Medicine, Veteran's Affairs Medical Center,…”
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Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes by Archer, S L, Souil, E, Dinh-Xuan, A T, Schremmer, B, Mercier, J C, El Yaagoubi, A, Nguyen-Huu, L, Reeve, H L, Hampl, V

“…Hypoxia initiates pulmonary vasoconstriction (HPV) by inhibiting one or more voltage-gated potassium channels (Kv) in the pulmonary artery smooth muscle cells…”
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Differential Distribution of Electrophysiologically Distinct Myocytes in Conduit and Resistance Arteries Determines Their Response to Nitric Oxide and Hypoxia by Archer, Stephen L, Huang, James, Reeve, Helen L, Hampl, Vaclav, Tolarova, Simona, Michelakis, Evangelos, Weir, E. Kenneth

“…The cellular mechanisms that determine differences in reactivity of arteries of varying size and origin are unknown. We evaluated the hypothesis that there is…”
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Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction by KENNETH WEIR, E, REEVE, H. L, HUANG, J. M. C, MICHELAKIS, E, NELSON, D. P, HAMPL, V, ARCHER, S. L

“…The appetite suppressant aminorex fumarate is thought to have caused an epidemic of pulmonary hypertension in Europe in the 1960s. More recently, pulmonary…”
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Oxygen Causes Fetal Pulmonary Vasodilation through Activation of a Calcium-Dependent Potassium Channel by Cornfield, David N., Reeve, Helen L., Tolarova, Simona, Weir, E. Kenneth, Archer, Stephen

“…At birth, pulmonary vasodilation occurs as air-breathing life begins. The mechanism of O2-induced pulmonary vasodilation is unknown. We proposed that O2 causes…”
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Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel by Tristani-Firouzi, M, Reeve, H L, Tolarova, S, Weir, E K, Archer, S L

“…The ductus arteriosus is a vital fetal structure allowing blood ejected from the right ventricle to bypass the pulmonary circulation in utero. Closure of the…”
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A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension by Weir, E K, Reeve, H L, Johnson, G, Michelakis, E D, Nelson, D P, Archer, S L

“…Plasma serotonin levels are markedly elevated in patients with primary pulmonary hypertension (PPH) and platelet levels of serotonin are low. Furthermore,…”
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Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells by Weir, E K, Wyatt, C N, Reeve, H L, Huang, J, Archer, S L, Peers, C

“…Diphenyleneiodonium (DPI) blocks hypoxic vasoconstriction in the pulmonary vasculature. Because one of the actions of DPI is the inhibition of NADPH oxidase,…”
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O2 Sensing Is Preserved in Mice Lacking the gp91 Phox Subunit of NADPH Oxidase by Archer, Stephen L., Reeve, Helen L., Michelakis, Evangelos, Puttagunta, Lakshmi, Waite, Ross, Nelson, Daniel P., Dinauer, Mary C., Weir, E. Kenneth

“…The rapid response to hypoxia in the pulmonary artery (PA), carotid body, and ductus arteriosus is partially mediated by O2-responsive K+ channels. K+ channels…”
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Glibenclamide inhibits a voltage-gated K+ current in the human neuroblastoma cell line SH-SY5Y by Reeve, H L, Vaughan, P F, Peers, C

“…The whole-cell patch-clamp technique was used to record outward K+ currents in the human neuroblastoma cell line SH-SY5Y. These K+ currents were inhibited by…”
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Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation by Archer, S L, Weir, E K, Reeve, H L, Michelakis, E

“…Small, muscular pulmonary arteries (PAs) constrict within seconds of the onset of alveolar hypoxia, diverting blood flow to better-ventilated lobes, thereby…”
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Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue by Reeve, H L, Weir, E K, Nelson, D P, Peterson, D A, Archer, S L

“…K+ channels regulate tone in both the systemic and pulmonary circulations. K+ channel inhibition leads to membrane depolarization, Ca2+ influx and…”
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Nicotinic acetylcholine receptors in human neuroblastoma (SH-SY5Y) cells by Gould, J, Reeve, H L, Vaughan, P F, Peers, C

“…Whole-cell patch-clamp recordings were used to investigate nicotinic acetylcholine receptors (nAChRs) in the human neuroblastoma cell line, SH-SY5Y…”
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Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture by Weir, E K, Reeve, H L, Peterson, D A, Michelakis, E D, Nelson, D P, Archer, S L

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Bradykinin-evoked release of [3H]noradrenaline from the human neuroblastoma SH-SY5Y by McDonald, R L, Kaye, D F, Reeve, H L, Ball, S G, Peers, C, Vaughan, P F

“…Bradykinin (BK) evoked [3H]noradrenaline ([3H]NA) release from the human neuroblastoma SH-SY5Y and this was enhanced by pre-treatment with…”
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Nicotinic receptor-mediated release of noradrenaline in the human neuroblastoma SH-SY5Y by Vaughan, P F, Kaye, D F, Reeve, H L, Ball, S G, Peers, C

“…Dimethylphenylpiperazinium iodide (a nicotinic agonist) evokes noradrenaline release from human neuroblastoma SH-SY5Y cells that have been pretreated with…”
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Blockade of delayed rectifier K+ currents in neuroblastoma x glioma hybrid (NG 108-15) cells by clofilium, a class III antidysrhythmic agent by Reeve, H L, Peers, C

“…1. The whole-cell patch-clamp technique was used to examine the effects of the class III antidysrhythmic agent, clofilium, on voltage-activated delayed…”
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Redox control of oxygen sensing in the rabbit ductus arteriosus by Reeve, Helen L., Tolarova, Simona, Nelson, Daniel P., Archer, Stephen, Weir, E. Kenneth

“…How the ductus arteriosus (DA) closes at birth remains unclear. Inhibition of O 2 -sensitive K + channels may initiate the closure but the sensor mechanism is…”
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Potassium channel diversity in vascular smooth muscle cells by Michelakis, E D, Reeve, H L, Huang, J M, Tolarova, S, Nelson, D P, Weir, E K, Archer, S L

“…Several recent observations suggest that the vascular medium is a mosaic of functionally and morphologically unique cell types. This diversity includes…”
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A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent by Reeve, H L, Weir, E K, Archer, S L, Cornfield, D N

“…The mechanism responsible for the abrupt decrease in resistance of the pulmonary circulation at birth may include changes in the activity of O2-sensitive K+…”
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