Search Results - "Reeser, Julie W"

Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance by Krook, Melanie A., Reeser, Julie W., Ernst, Gabrielle, Barker, Hannah, Wilberding, Max, Li, Gary, Chen, Hui-Zi, Roychowdhury, Sameek

“…Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of…”
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Evaluation of Hybridization Capture Versus Amplicon-Based Methods for Whole-Exome Sequencing by Samorodnitsky, Eric, Jewell, Benjamin M., Hagopian, Raffi, Miya, Jharna, Wing, Michele R., Lyon, Ezra, Damodaran, Senthilkumar, Bhatt, Darshna, Reeser, Julie W., Datta, Jharna, Roychowdhury, Sameek

“…ABSTRACT Next‐generation sequencing has aided characterization of genomic variation. While whole‐genome sequencing may capture all possible mutations,…”
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Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma by Krook, Melanie A, Lenyo, Alexandria, Wilberding, Max, Barker, Hannah, Dantuono, Mikayla, Bailey, Kelly M, Chen, Hui-Zi, Reeser, Julie W, Wing, Michele R, Miya, Jharna, Samorodnitsky, Eric, Smith, Amy M, Dao, Thuy, Martin, Dorrelyn M, Ciombor, Kristen K, Hays, John, Freud, Aharon G, Roychowdhury, Sameek

“…The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in approximately 15% to 20% of patients with intrahepatic…”
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Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398 by Datta, Jharna, Damodaran, Senthilkumar, Parks, Hannah, Ocrainiciuc, Cristina, Miya, Jharna, Yu, Lianbo, Gardner, Elijah P, Samorodnitsky, Eric, Wing, Michele R, Bhatt, Darshna, Hays, John, Reeser, Julie W, Roychowdhury, Sameek

“…Activation of FGFR signaling through mutations, amplifications, or fusions involving , or is seen in multiple tumors, including lung, bladder, and…”
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Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers by Genutis, Luke K, Tomsic, Jerneja, Bundschuh, Ralf A, Brock, Pamela L, Williams, Michelle D, Roychowdhury, Sameek, Reeser, Julie W, Frankel, Wendy L, Alsomali, Mohammed, Routbort, Mark J, Broaddus, Russell R, Wakely, Jr, Paul E, Phay, John E, Walker, Christopher J, de la Chapelle, Albert

“…Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite instability (MSI) are frequently observed in endometrial, stomach, and colorectal…”
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Myeloid neoplasm with histiocytosis and spleen tyrosine kinase fusion responds to fostamatinib by Risch, Zachary, Kaffenberger, Benjamin H, Chung, Catherine G, Samorodnitsky, Eric, Hoskins, Emily L, Dao, Thuy, Smith, Amy, Wall, Sarah A, Brammer, Jonathan, Reeser, Julie W, Wing, Michele R, Hopkins, Julia F, Albacker, Lee A, Abruzzo, Lynne V, Eisele, Caprice D, Freud, Aharon G, Roychowdhury, Sameek, Walsh, Katherine E

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Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors by Reeser, Julie W., Martin, Dorrelyn, Miya, Jharna, Kautto, Esko A., Lyon, Ezra, Zhu, Eliot, Wing, Michele R., Smith, Amy, Reeder, Matthew, Samorodnitsky, Eric, Parks, Hannah, Naik, Karan R., Gozgit, Joseph, Nowacki, Nicholas, Davies, Kurtis D., Varella-Garcia, Marileila, Yu, Lianbo, Freud, Aharon G., Coleman, Joshua, Aisner, Dara L., Roychowdhury, Sameek

“…Kinase gene fusions are important drivers of oncogenic transformation and can be inhibited with targeted therapies. Clinical grade diagnostics using RNA…”
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Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy by Krook, Melanie A, Bonneville, Russell, Chen, Hui-Zi, Reeser, Julie W, Wing, Michele R, Martin, Dorrelyn M, Smith, Amy M, Dao, Thuy, Samorodnitsky, Eric, Paruchuri, Anoosha, Miya, Jharna, Baker, Kaitlin R, Yu, Lianbo, Timmers, Cynthia, Dittmar, Kristin, Freud, Aharon G, Allenby, Patricia, Roychowdhury, Sameek

“…Cholangiocarcinoma is a highly aggressive and lethal malignancy, with limited treatment options available. Recently, FGFR inhibitors have been developed and…”
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439 Extracellular-in-frame deletions and kinase domain duplications are novel, gain-of-function mutations in fibroblast growth factor receptor genes in cancer by Stein, Leah, Reeser, Julie W., Wing, Michele R., Li, Chunjie, Murugesan, Karthikeyan, Pavlick, Dean, Hoskins, Emily L., Vella, Raven, Rigsbee, Georgia, Roychowdhury, Sameek

“…OBJECTIVES/GOALS: There are gain-of-function genomic alterations in FGFR genes that guide personalized treatment in some patients with cholangiocarcinoma (10%)…”
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FGFR2-fusions define a clinically actionable molecular subset of pancreatic cancer by Stein, Leah, Murugesan, Karthikeyan, Reeser, Julie W., Risch, Zachary, Wing, Michele R., Paruchuri, Anoosha, Samorodnitsky, Eric, Hoskins, Emily L., Dao, Thuy, Smith, Amy, Le, Dat, Babcook, Melissa A., Chang, Yi Seok, Avenarius, Matthew R., Imam, Muhammad, Freud, Aharon G., Roychowdhury, Sameek

“…Genomic alterations in fibroblast growth factor receptor ( FGFR) genes are present in a small number of metastatic pancreatic ductal adenocarcinomas (PDAC) and…”
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Performance evaluation for rapid detection of pan-cancer microsatellite instability with MANTIS by Kautto, Esko A, Bonneville, Russell, Miya, Jharna, Yu, Lianbo, Krook, Melanie A, Reeser, Julie W, Roychowdhury, Sameek

“…In current clinical practice, microsatellite instability (MSI) and mismatch repair deficiency detection is performed with MSI-PCR and immunohistochemistry…”
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Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy by Chen, Hui-Zi, Bonneville, Russell, Paruchuri, Anoosha, Reeser, Julie W., Wing, Michele R., Samorodnitsky, Eric, Krook, Melanie A., Smith, Amy M., Dao, Thuy, Miya, Jharna, Wang, Walter, Yu, Lianbo, Freud, Aharon G., Allenby, Patricia, Cole, Sharon, Otterson, Gregory, Shields, Peter, Carbone, David P., Roychowdhury, Sameek

“…Relapsed SCLC is characterized by therapeutic resistance and high mortality rate. Despite decades of research, mechanisms responsible for…”
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Cancer Driver Log (CanDL): Catalog of Potentially Actionable Cancer Mutations by Damodaran, Senthilkumar, Miya, Jharna, Kautto, Esko, Zhu, Eliot, Samorodnitsky, Eric, Datta, Jharna, Reeser, Julie W, Roychowdhury, Sameek

“…Massively parallel sequencing technologies have enabled characterization of genomic alterations across multiple tumor types. Efforts have focused on…”
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Comparison of Custom Capture for Targeted Next-Generation DNA Sequencing by Samorodnitsky, Eric, Datta, Jharna, Jewell, Benjamin M, Hagopian, Raffi, Miya, Jharna, Wing, Michele R, Damodaran, Senthilkumar, Lippus, Juliana M, Reeser, Julie W, Bhatt, Darshna, Timmers, Cynthia D, Roychowdhury, Sameek

“…Targeted, capture-based DNA sequencing is a cost-effective method to focus sequencing on a coding region or other customized region of the genome. There are…”
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Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing by Bonneville, Russell, Paruchuri, Anoosha, Wing, Michele R, Krook, Melanie A, Reeser, Julie W, Chen, Hui-Zi, Dao, Thuy, Samorodnitsky, Eric, Smith, Amy M, Yu, Lianbo, Nowacki, Nicholas, Chen, Wei, Roychowdhury, Sameek

“…Microsatellites are short, repetitive segments of DNA, which are dysregulated in mismatch repair-deficient (MMRd) tumors resulting in microsatellite…”
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Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia by Andritsos, Leslie A., Grieselhuber, Nicole R., Anghelina, Mirela, Rogers, Kerry A., Roychowdhury, Sameek, Reeser, Julie W., Timmers, Cynthia D., Freud, Aharon G., Blachly, James S., Lucas, David M., Lozanski, Gerard, Jones, Jeffrey A., Williams, Katie, Oakes, Christopher, Jones, Dan, Grever, Michael R.

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Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations by Martin, Dorrelyn P, Miya, Jharna, Reeser, Julie W, Roychowdhury, Sameek

“…RNA sequencing (RNAseq) is a versatile method that can be utilized to detect and characterize gene expression, mutations, gene fusions, and noncoding RNAs…”
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Genomic characterization of metastatic ultra-hypermutated interdigitating dendritic cell sarcoma through rapid research autopsy by Chen, Hui-Zi, Bonneville, Russell, Yu, Lianbo, Wing, Michele R, Reeser, Julie W, Krook, Melanie A, Miya, Jharna, Samorodnitsky, Eric, Smith, Amy, Martin, Dorrelyn, Dao, Thuy, Guo, Qishan, Liebner, David, Freud, Aharon G, Allenby, Patricia, Roychowdhury, Sameek

“…Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare cancer of dendritic cell origin that lacks a standardized treatment approach. Here, we…”
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Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer by Krook, Melanie A., Barker, Hannah, Chen, Hui-Zi, Reeser, Julie W., Wing, Michele R., Martin, Dorrelyn, Smith, Amy M., Dao, Thuy, Bonneville, Russell, Samorodnitsky, Eric, Miya, Jharna, Freud, Aharon G., Monk, J. Paul, Clinton, Steven K., Roychowdhury, Sameek

“…Background The fibroblast growth factor receptor (FGFR) signaling pathway is activated in multiple tumor types through gene amplifications, single base…”
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Cancer Driver Log (CanDL) by Damodaran, Senthilkumar, Miya, Jharna, Kautto, Esko, Zhu, Eliot, Samorodnitsky, Eric, Datta, Jharna, Reeser, Julie W, Roychowdhury, Sameek

“…Massively parallel sequencing technologies have enabled characterization of genomic alterations across multiple tumor types. Efforts have focused on…”
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