Search Results - "Reese, Rebecca M."

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma by Reese, Rebecca M., Dourado, Michelle, Anderson, Keith, Warming, Søren, Stark, Kimberly L., Balestrini, Alessia, Suto, Eric, Lee, Wyne, Riol-Blanco, Lorena, Shields, Shannon D., Hackos, David H.

“…The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP…”
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Nucleus Accumbens and Posterior Amygdala Mediate Cue-Triggered Alcohol Seeking and Suppress Behavior During the Omission of Alcohol-Predictive Cues by Millan, E Zayra, Reese, Rebecca M, Grossman, Cooper D, Chaudhri, Nadia, Janak, Patricia H

“…Neurobiological mechanisms that influence behavior in the presence of alcohol-associated stimuli involve processes that organize behavior during the presence…”
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Grainyhead-like Protein 2: The Emerging Role in Hormone-Dependent Cancers and Epigenetics by Reese, Rebecca M, Harrison, Melissa M, Alarid, Elaine T

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Inhibiting Mesolimbic Dopamine Neurons Reduces the Initiation and Maintenance of Instrumental Responding by Fischbach-Weiss, Sarah, Reese, Rebecca M., Janak, Patricia H.

“…•Is midbrain dopamine neuron activity required for responding on fixed ratio and progressive ratio tasks in mice?•Optogenetic inhibition of dopamine neurons…”
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Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors by Shields, Shannon D, Deng, Lunbin, Reese, Rebecca M, Dourado, Michelle, Tao, Janet, Foreman, Oded, Chang, Jae H, Hackos, David H

“…Strong human genetic evidence points to an essential contribution of the voltage-gated sodium channel Nav1.7 to pain sensation: loss of Nav1.7 function leads…”
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GRHL2 Enhances Phosphorylated Estrogen Receptor (ER) Chromatin Binding and Regulates ER-Mediated Transcriptional Activation and Repression by Reese, Rebecca M., Helzer, Kyle T., Allen, Kaelyn O., Zheng, Christy, Solodin, Natalia, Alarid, Elaine T.

“…Phosphorylation of estrogen receptor α (ER) at serine 118 (pS118-ER) is induced by estrogen and is the most abundant posttranslational mark associated with a…”
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Grainyhead-like Protein 2: The Emerging Role in Hormone-Dependent Cancers and Epigenetics by Reese, Rebecca M, Harrison, Melissa M, Alarid, Elaine T

“…In mammals, the grainyhead-like transcription factor (GRHL) family is composed of three nuclear proteins that are responsible for driving epithelial cell fate:…”
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Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala by Sciascia, Joanna M, Reese, Rebecca M, Janak, Patricia H, Chaudhri, Nadia

“…The environmental context in which a discrete Pavlovian conditioned stimulus (CS) is experienced can profoundly impact conditioned responding elicited by the…”
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Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids by Deng, Lunbin, Dourado, Michelle, Reese, Rebecca M., Huang, Kevin, Shields, Shannon D., Stark, Kimberly L., Maksymetz, James, Lin, Han, Kaminker, Joshua S., Jung, Min, Foreman, Oded, Tao, Janet, Ngu, Hai, Joseph, Victory, Roose-Girma, Meron, Tam, Lucinda, Lardell, Susanne, Orrhult, Linnea Strid, Karila, Paul, Allard, Julien, Hackos, David H.

“…Loss-of-function mutations in Nav1.7, a voltage-gated sodium channel, cause congenital insensitivity to pain (CIP) in humans, demonstrating that Nav1.7 is…”
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A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment by Balestrini, Alessia, Joseph, Victory, Dourado, Michelle, Reese, Rebecca M, Shields, Shannon D, Rougé, Lionel, Bravo, Daniel D, Chernov-Rogan, Tania, Austin, Cary D, Chen, Huifen, Wang, Lan, Villemure, Elisia, Shore, Daniel G M, Verma, Vishal A, Hu, Baihua, Chen, Yong, Leong, Laurie, Bjornson, Chris, Hötzel, Kathy, Gogineni, Alvin, Lee, Wyne P, Suto, Eric, Wu, Xiumin, Liu, John, Zhang, Juan, Gandham, Vineela, Wang, Jianyong, Payandeh, Jian, Ciferri, Claudio, Estevez, Alberto, Arthur, Christopher P, Kortmann, Jens, Wong, Ryan L, Heredia, Jose E, Doerr, Jonas, Jung, Min, Vander Heiden, Jason A, Roose-Girma, Merone, Tam, Lucinda, Barck, Kai H, Carano, Richard A D, Ding, Han Ting, Brillantes, Bobby, Tam, Christine, Yang, Xiaoying, Gao, Simon S, Ly, Justin Q, Liu, Liling, Chen, Liuxi, Liederer, Bianca M, Lin, Joseph H, Magnuson, Steven, Chen, Jun, Hackos, David H, Elstrott, Justin, Rohou, Alexis, Safina, Brian S, Volgraf, Matthew, Bauer, Rebecca N, Riol-Blanco, Lorena

“…Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and…”
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Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1 by Lung, David K., Reese, Rebecca M., Alarid, Elaine T.

“…Transcriptional regulation of ESR1 , the gene that encodes for estrogen receptor α (ER), is critical for regulating the downstream effects of the estrogen…”
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The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2 by Helzer, Kyle T., Szatkowski Ozers, Mary, Meyer, Mark B., Benkusky, Nancy A., Solodin, Natalia, Reese, Rebecca M., Warren, Christopher L., Pike, J. Wesley, Alarid, Elaine T.

“…Posttranslational modifications are key regulators of protein function, providing cues that can alter protein interactions and cellular location…”
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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy by Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew

“…Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a…”
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The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options by Keiflin, Ronald, Reese, Rebecca M, Woods, Catherine A, Janak, Patricia H

“…Animals rely on environmental cues to identify potential rewards and select the best reward available. The orbitofrontal cortex (OFC) is proposed to encode…”
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A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists by Villemure, Elisia, Terrett, Jack A, Larouche-Gauthier, Robin, Déry, Martin, Chen, Huifen, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Magnuson, Steven, Volgraf, Matthew

“…Transient receptor potential ankyrin 1 (TRPA1) antagonists have generated broad interest in the pharmaceutical industry for the treatment of both pain and…”
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Dorsomedial and dorsolateral striatum exhibit distinct phasic neuronal activity during alcohol self-administration in rats by Fanelli, Rebecca R., Klein, Jeffrey T., Reese, Rebecca M., Robinson, Donita L.

“…The development of alcoholism may involve a shift from goal‐directed to habitual drinking. These action control systems are distinct in the dorsal striatum,…”
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Progesterone Receptor-Mediated Regulation of Cellular Glucose and [sup.18]F-Fluorodeoxyglucose Uptake in Breast Cancer by Salem, Kelley, Reese, Rebecca M, Alarid, Elaine T, Fowler, Amy M

“…Context: Positron emission tomography imaging with 2-deoxy-2-[[sup.18]F]-fluoro- D-glucose (FDG) is used clinically for initial staging, restaging, and…”
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Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling by Chen, Huifen, Volgraf, Matthew, Do, Steven, Kolesnikov, Aleksandr, Shore, Daniel G, Verma, Vishal A, Villemure, Elisia, Wang, Lan, Chen, Yong, Hu, Baihua, Lu, Ai-Jun, Wu, Guosheng, Xu, Xiaofeng, Yuen, Po-wai, Zhang, Yamin, Erickson, Shawn D, Dahl, Martin, Brotherton-Pleiss, Christine, Tay, Suzanne, Ly, Justin Q, Murray, Lesley J, Chen, Jun, Amm, Desiree, Lange, Wienke, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Lyssikatos, Joseph P, Safina, Brian S, Estrada, Anthony A

“…Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a…”
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Grainyhead-likeProtein 2: The Emerging Role in Hormone-Dependent Cancers and Epigenetics by Reese, Rebecca M, Harrison, Melissa M, Alarid, Elaine T

“…In mammals, the grainyhead-like transcription factor (GRHL) family is composed of three nuclear proteins that are responsible for driving epithelial cell fate:…”
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Grainyhead-Like Protein 2 Regulates the Transcriptional Activity of Estrogen Receptor Alpha Phosphorylated at Serine 118 in Breast Cancer by Reese, Rebecca M

“…The Grainyhead-like protein family, composed of GRHL1, GRHL2, and GRHL3, are nuclear transcription factors that regulate epithelial differentiation. GRHL2 is…”
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