Search Results - "Reese, Rebecca"

Inhibiting Mesolimbic Dopamine Neurons Reduces the Initiation and Maintenance of Instrumental Responding by Fischbach-Weiss, Sarah, Reese, Rebecca M., Janak, Patricia H.

“…•Is midbrain dopamine neuron activity required for responding on fixed ratio and progressive ratio tasks in mice?•Optogenetic inhibition of dopamine neurons…”
Get full text

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors by Shields, Shannon D, Deng, Lunbin, Reese, Rebecca M, Dourado, Michelle, Tao, Janet, Foreman, Oded, Chang, Jae H, Hackos, David H

“…Strong human genetic evidence points to an essential contribution of the voltage-gated sodium channel Nav1.7 to pain sensation: loss of Nav1.7 function leads…”
Get full text

GRHL2 Enhances Phosphorylated Estrogen Receptor (ER) Chromatin Binding and Regulates ER-Mediated Transcriptional Activation and Repression by Reese, Rebecca M., Helzer, Kyle T., Allen, Kaelyn O., Zheng, Christy, Solodin, Natalia, Alarid, Elaine T.

“…Phosphorylation of estrogen receptor α (ER) at serine 118 (pS118-ER) is induced by estrogen and is the most abundant posttranslational mark associated with a…”
Get full text

Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma by Reese, Rebecca M., Dourado, Michelle, Anderson, Keith, Warming, Søren, Stark, Kimberly L., Balestrini, Alessia, Suto, Eric, Lee, Wyne, Riol-Blanco, Lorena, Shields, Shannon D., Hackos, David H.

“…The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP…”
Get full text

Grainyhead-like Protein 2: The Emerging Role in Hormone-Dependent Cancers and Epigenetics by Reese, Rebecca M, Harrison, Melissa M, Alarid, Elaine T

“…In mammals, the grainyhead-like transcription factor (GRHL) family is composed of three nuclear proteins that are responsible for driving epithelial cell fate:…”
Get full text

Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala by Sciascia, Joanna M, Reese, Rebecca M, Janak, Patricia H, Chaudhri, Nadia

“…The environmental context in which a discrete Pavlovian conditioned stimulus (CS) is experienced can profoundly impact conditioned responding elicited by the…”
Get full text

Nucleus Accumbens and Posterior Amygdala Mediate Cue-Triggered Alcohol Seeking and Suppress Behavior During the Omission of Alcohol-Predictive Cues by Millan, E Zayra, Reese, Rebecca M, Grossman, Cooper D, Chaudhri, Nadia, Janak, Patricia H

“…Neurobiological mechanisms that influence behavior in the presence of alcohol-associated stimuli involve processes that organize behavior during the presence…”
Get full text

Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids by Deng, Lunbin, Dourado, Michelle, Reese, Rebecca M., Huang, Kevin, Shields, Shannon D., Stark, Kimberly L., Maksymetz, James, Lin, Han, Kaminker, Joshua S., Jung, Min, Foreman, Oded, Tao, Janet, Ngu, Hai, Joseph, Victory, Roose-Girma, Meron, Tam, Lucinda, Lardell, Susanne, Orrhult, Linnea Strid, Karila, Paul, Allard, Julien, Hackos, David H.

“…Loss-of-function mutations in Nav1.7, a voltage-gated sodium channel, cause congenital insensitivity to pain (CIP) in humans, demonstrating that Nav1.7 is…”
Get full text

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment by Balestrini, Alessia, Joseph, Victory, Dourado, Michelle, Reese, Rebecca M, Shields, Shannon D, Rougé, Lionel, Bravo, Daniel D, Chernov-Rogan, Tania, Austin, Cary D, Chen, Huifen, Wang, Lan, Villemure, Elisia, Shore, Daniel G M, Verma, Vishal A, Hu, Baihua, Chen, Yong, Leong, Laurie, Bjornson, Chris, Hötzel, Kathy, Gogineni, Alvin, Lee, Wyne P, Suto, Eric, Wu, Xiumin, Liu, John, Zhang, Juan, Gandham, Vineela, Wang, Jianyong, Payandeh, Jian, Ciferri, Claudio, Estevez, Alberto, Arthur, Christopher P, Kortmann, Jens, Wong, Ryan L, Heredia, Jose E, Doerr, Jonas, Jung, Min, Vander Heiden, Jason A, Roose-Girma, Merone, Tam, Lucinda, Barck, Kai H, Carano, Richard A D, Ding, Han Ting, Brillantes, Bobby, Tam, Christine, Yang, Xiaoying, Gao, Simon S, Ly, Justin Q, Liu, Liling, Chen, Liuxi, Liederer, Bianca M, Lin, Joseph H, Magnuson, Steven, Chen, Jun, Hackos, David H, Elstrott, Justin, Rohou, Alexis, Safina, Brian S, Volgraf, Matthew, Bauer, Rebecca N, Riol-Blanco, Lorena

“…Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and…”
Get full text

Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1 by Lung, David K., Reese, Rebecca M., Alarid, Elaine T.

“…Transcriptional regulation of ESR1 , the gene that encodes for estrogen receptor α (ER), is critical for regulating the downstream effects of the estrogen…”
Get full text

A review of biosimilars in psoriasis: impacts on efficacy, safety, access, and a first-hand look at biosimilar cost savings within the department of veterans affairs by Reese, Rebecca, Nanavath, Shiva Ram, Martin, Jennifer, Travers, Jeffrey B, Rohan, Craig A

“…Psoriasis is a chronic immune-mediated systemic disease whose treatment has been revolutionized due to the induction of monoclonal antibody-based biologics…”
Get full text

The Assessment of Readiness and Consent for Hormone Therapy: A Semi-structured Interview for Use With Transgender and Gender Nonconforming Individuals by Reese Akcakaya, Rebecca L., Mori, DeAnna L.

“…Evaluations to determine one's readiness to initiate hormone therapy are often requested by endocrinologists or institutions who provide gender-affirming…”
Get full text

The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2 by Helzer, Kyle T., Szatkowski Ozers, Mary, Meyer, Mark B., Benkusky, Nancy A., Solodin, Natalia, Reese, Rebecca M., Warren, Christopher L., Pike, J. Wesley, Alarid, Elaine T.

“…Posttranslational modifications are key regulators of protein function, providing cues that can alter protein interactions and cellular location…”
Get full text

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy by Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew

“…Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a…”
Get full text

The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options by Keiflin, Ronald, Reese, Rebecca M, Woods, Catherine A, Janak, Patricia H

“…Animals rely on environmental cues to identify potential rewards and select the best reward available. The orbitofrontal cortex (OFC) is proposed to encode…”
Get full text

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists by Villemure, Elisia, Terrett, Jack A, Larouche-Gauthier, Robin, Déry, Martin, Chen, Huifen, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Magnuson, Steven, Volgraf, Matthew

“…Transient receptor potential ankyrin 1 (TRPA1) antagonists have generated broad interest in the pharmaceutical industry for the treatment of both pain and…”
Get full text

Dorsomedial and dorsolateral striatum exhibit distinct phasic neuronal activity during alcohol self-administration in rats by Fanelli, Rebecca R., Klein, Jeffrey T., Reese, Rebecca M., Robinson, Donita L.

“…The development of alcoholism may involve a shift from goal‐directed to habitual drinking. These action control systems are distinct in the dorsal striatum,…”
Get full text

Progesterone Receptor-Mediated Regulation of Cellular Glucose and [sup.18]F-Fluorodeoxyglucose Uptake in Breast Cancer by Salem, Kelley, Reese, Rebecca M, Alarid, Elaine T, Fowler, Amy M

“…Context: Positron emission tomography imaging with 2-deoxy-2-[[sup.18]F]-fluoro- D-glucose (FDG) is used clinically for initial staging, restaging, and…”
Get full text

Positive impact of nutrition in the prevention of peripheral vascular disease and severe acute respiratory syndrome coronavirus 2: review by Karim, Zubair A, Reese, Rebecca A, Smith, Adrianne N, Blackadar, Madeline E, Arora, Vishal, Moore, Nicole M, Johnson, Emily A

“…Recent research has shown that there is a link between the trend of cardiovascular disease (CVD), chronic symptoms of SARS-CoV-2 (COVID-19), and medical…”
Get full text

Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling by Chen, Huifen, Volgraf, Matthew, Do, Steven, Kolesnikov, Aleksandr, Shore, Daniel G, Verma, Vishal A, Villemure, Elisia, Wang, Lan, Chen, Yong, Hu, Baihua, Lu, Ai-Jun, Wu, Guosheng, Xu, Xiaofeng, Yuen, Po-wai, Zhang, Yamin, Erickson, Shawn D, Dahl, Martin, Brotherton-Pleiss, Christine, Tay, Suzanne, Ly, Justin Q, Murray, Lesley J, Chen, Jun, Amm, Desiree, Lange, Wienke, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Lyssikatos, Joseph P, Safina, Brian S, Estrada, Anthony A

“…Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a…”
Get full text