Search Results - "Rees, William A"

Serum Glial Fibrillary Acidic Protein: A Neuromyelitis Optica Spectrum Disorder Biomarker by Aktas, Orhan, Smith, Michael A., Rees, William A., Bennett, Jeffrey L., She, Dewei, Katz, Eliezer, Cree, Bruce A. C., Fujihara, Kazuo, Paul, Friedemann, Hartung, Hans‐Peter, Marignier, Romain, Kim, Ho Jin, Weinshenker, Brian G., Pittock, Sean J., Wingerchuk, Dean M., Cutter, Gary R., Green, Ari J., Mealy, Maureen A., Drappa, Jorn

“…Objective Blood tests to monitor disease activity, attack severity, or treatment impact in neuromyelitis optica spectrum disorder (NMOSD) have not been…”
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Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, Patients With Moderate to Severe Crohn's Disease: a Phase 2a Study by Sands, Bruce E., MD, Chen, Jingjing, PhD, Feagan, Brian G., MD, Penney, Mark, PhD, Rees, William A., Ph.D, Danese, Silvio, MD, PhD, Higgins, Peter D.R., MD, PhD, Newbold, Paul, PhD, Faggioni, Raffaella, PhD, Patra, Kaushik, PhD, Li, Jing, PhD, Klekotka, Paul, MD, PhD, Morehouse, Chris, MS, Pulkstenis, Erik, PhD, Drappa, Jörn, MD, PhD, van der Merwe, René, MBChB, Gasser, Robert A., MD

“…Abstract Background & Aims MEDI2070 is a human monoclonal antibody that selectively inhibits interleukin 23 (IL23), a cytokine implicated in the pathogenesis…”
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B cell and aquaporin‐4 antibody relationships with neuromyelitis optica spectrum disorder activity by Bennett, Jeffrey L., Pittock, Sean J., Paul, Friedemann, Kim, Ho Jin, Irani, Sarosh R., O'Connor, Kevin C., Patterson, Kristina R., Smith, Michael A., Gunsior, Michele, Mittereder, Nanette, Rees, William A., Cimbora, Daniel, Cree, Bruce A. C.

“…This post hoc analysis of the randomized, placebo‐controlled N‐MOmentum study (NCT02200770) of inebilizumab in neuromyelitis optica spectrum disorder (NMOSD)…”
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Inebilizumab reduces neuromyelitis optica spectrum disorder risk independent of FCGR3A polymorphism by Kim, Ho Jin, Aktas, Orhan, Patterson, Kristina R., Korff, Schaun, Kunchok, Amy, Bennett, Jeffrey L., Weinshenker, Brian G., Paul, Friedemann, Hartung, Hans‐Peter, Cimbora, Daniel, Smith, Michael A., Mittereder, Nanette, Rees, William A., She, Dewei, Cree, Bruce A. C.

“…Inebilizumab, a humanized, glycoengineered, IgG1 monoclonal antibody that depletes CD19+ B‐cells, is approved to treat aquaporin 4 (AQP4) IgG‐seropositive…”
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Population Pharmacokinetic Modeling of Inebilizumab in Subjects with Neuromyelitis Optica Spectrum Disorders, Systemic Sclerosis, or Relapsing Multiple Sclerosis by Yan, Li, Kimko, Holly, Wang, Bing, Cimbora, Daniel, Katz, Eliezer, Rees, William A.

“…Background and Objective Inebilizumab is a humanized, affinity-optimized, afucosylated immunoglobulin (Ig)-G1κ monoclonal antibody that binds to CD19,…”
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Pharmacodynamic modelling and exposure–response assessment of inebilizumab in subjects with neuromyelitis optica spectrum disorders by Yan, Li, Wang, Bing, She, Dewei, Mitchell, Ben, Criste, Ryan, Cimbora, Daniel, Katz, Eliezer, Rees, William A.

“…Aims Neuromyelitis optica spectrum disorders (NMOSD) is an autoantibody‐mediated, B cell‐driven disease. Inebilizumab is a humanized, affinity‐optimized,…”
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Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus by Karnell, Jodi L, Wu, Yanping, Mittereder, Nanette, Smith, Michael A, Gunsior, Michele, Yan, Li, Casey, Kerry A, Henault, Jill, Riggs, Jeffrey M, Nicholson, Simone M, Sanjuan, Miguel A, Vousden, Katherine A, Werth, Victoria P, Drappa, Jörn, Illei, Gabor G, Rees, William A, Ratchford, John N

“…Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable…”
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Prediction of clinical pharmacokinetics of AMG 181, a human anti‐α4β7 monoclonal antibody for treating inflammatory bowel diseases by Li, Hong, Köck, Kathleen, Wisler, John A., Rees, William A., Prince, Peter J., Reynhardt, Kai O., Hsu, Hailing, Yu, Zhigang, Borie, Dominic C., Salinger, David H., Pan, Wei‐Jian

“…The purpose of this study was to predict a safe starting dose of AMG 181, a human anti‐α4β7 antibody for treating inflammatory bowel diseases, based on…”
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Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in neuromyelitis optica spectrum disorder by Aktas, Orhan, Hartung, Hans-Peter, Smith, Michael A, Rees, William A, Fujihara, Kazuo, Paul, Friedemann, Marignier, Romain, Bennett, Jeffrey L, Kim, Ho Jin, Weinshenker, Brian G, Pittock, Sean J, Wingerchuk, Dean M, Cutter, Gary, She, Dewei, Gunsior, Michele, Cimbora, Daniel, Katz, Eliezer, Cree, Bruce A

“…ObjectiveTo investigate relationships between serum neurofilament light chain (sNfL), ubiquitin C-terminal hydrolase L1 (sUCHL1), tau (sTau) and glial…”
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CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial by St. Clair, E. William, Baer, Alan N., Ng, Wan-Fai, Noaiseh, Ghaith, Baldini, Chiara, Tarrant, Teresa K., Papas, Athena, Devauchelle-Pensec, Valerie, Wang, Liangwei, Xu, Wenjing, Pham, Tuyet-Hang, Sikora, Keith, Rees, William A., Alevizos, Ilias

“…Sjögren’s disease (SjD) is a chronic, systemic autoimmune disease with no approved disease-modifying therapies. Dazodalibep (DAZ), a novel nonantibody fusion…”
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Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus by Smith, Michael A., Chiang, Chia-Chien, Zerrouki, Kamelia, Rahman, Saifur, White, Wendy I., Streicher, Katie, Rees, William A., Schiffenbauer, Adam, Rider, Lisa G., Miller, Frederick W., Manna, Zerai, Hasni, Sarfaraz, Kaplan, Mariana J., Siegel, Richard, Sinibaldi, Dominic, Sanjuan, Miguel A., Casey, Kerry A.

“…Type I interferon (IFN) drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts in blood. Here, we examined…”
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Association between B-cell depletion and attack risk in neuromyelitis optica spectrum disorder: An exploratory analysis from N-MOmentum, a double-blind, randomised, placebo-controlled, multicentre phase 2/3 trial by Bennett, Jeffrey L., Aktas, Orhan, Rees, William A., Smith, Michael A., Gunsior, Michele, Yan, Li, She, Dewei, Cimbora, Daniel, Pittock, Sean J., Weinshenker, Brian G., Paul, Friedemann, Marignier, Romain, Wingerchuk, Dean, Cutter, Gary, Green, Ari, Hartung, Hans-Peter, Kim, Ho Jin, Fujihara, Kazuo, Levy, Michael, Katz, Eliezer, Cree, Bruce A.C.

“…Inebilizumab is an anti-CD19 antibody approved for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults with aquaporin-4 autoantibodies…”
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Betaine can eliminate the base pair composition dependence of DNA melting by Rees, William A, Yager, Thomas D, Korte, John, Von Hippel, Peter H

“…We show that the amino acid analogue betaine shares with small tetraalkylammonium ions [Melchior, W. B., Jr., & von Hippel, P. H. (1973) Proc. Natl. Acad. Sci…”
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Evidence of DNA Bending in Transcription Complexes Imaged by Scanning Force Microscopy by Rees, William A., Keller, Rebecca W., Vesenka, James P., Yang, Guoliang, Bustamante, Carlos

“…Complexes of Escherichia coli RNA polymerase with DNA containing the λ P$_L$ promoter have been deposited on mica and imaged in air with a scanning force…”
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Clinical pharmacology of AMG 181, a gut‐specific human anti‐α4β7 monoclonal antibody, for treating inflammatory bowel diseases by Pan, Wei‐Jian, Köck, Kathleen, Rees, William A., Sullivan, Barbara A., Evangelista, Christine M., Yen, Mark, Andrews, Jane M., Radford‐Smith, Graham L., Prince, Peter J., Reynhardt, Kaz O., Doherty, David R., Patel, Sonal K., Krill, Christine D., Zhou, Kefei, Shen, Jing, Smith, Lynn E., Gow, Jason M., Lee, Jonathan, Treacy, Anthony M., Yu, Zhigang, Platt, Virginia M., Borie, Dominic C.

“…Aims AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration…”
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A 12-Month, Randomized, Controlled Study to Evaluate Exposure and Cardiovascular Risk Factors in Adult Smokers Switching From Conventional Cigarettes to a Second-Generation Electrically Heated Cigarette Smoking System by Roethig, Hans J., Feng, Shixia, Liang, Qiwei, Liu, Jianmin, Rees, William A., Zedler, Barbara K.

“…This randomized, controlled, forced‐switching, open‐label, parallel‐group study in 97 adult male and female smokers of conventional cigarettes evaluated…”
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Bridging the Divide between Manual Gating and Bioinformatics with the Bioconductor Package flowFlowJo by Gosink, John J., Means, Gary D., Rees, William A., Su, Cheng, Rand, Hugh A.

“…In flow cytometry, different cell types are usually selected or “gated” by a series of 1- or 2-dimensional geometric subsets of the measurements made on each…”
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Sa1206 Multiple-Dose Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of AMG 181, a Human Anti-a4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD) by Pan, Wei-Jian, Sullivan, Barbara A, Rees, William A, Evangelista, Christine M, Doherty, David R, Prince, Peter J, Reynhardt, Kai O, Zhou, Kefei, Yen, Mark, Hooper, Michele M, Lee, Jonathan, Yu, Zhigang, Hsu, Hailing, Borie, Dominique C

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Sa1844 Inflammation-Associated Transcriptional Changes in Intestinal Tissue From Ulcerative Colitis and Crohn's Disease Patients by Simms, Lisa A, Walker, Nicole M, Hu, Richard, Misura, Kira, Price, Gareth R, Newhall, Kathryn, Venter, Deon, Wall, Jason, Thor, Christopher, Nguyen, Thu H, Huang, Ning, Gallagher, Renee L, Rees, William A, Russell, Christopher B, Symons, Antony, Towne, Jennifer, Tsuji, Wayne, Radford-Smith, Graham

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Sa1207 Pharmacokinetics/Pharmacodynamics (PK/PD), Efficacy, and Safety of AMG 181 in Subjects With Active, Mild to Moderate Ulcerative Colitis - An Initial Assessment by Pan, Wei-Jian, Radford-Smith, Graham, Andrews, Jane M, Schwartz, Howard I, Sullivan, Barbara A, Evangelista, Christine M, Rees, William A, Doherty, David R, Prince, Peter J, Reynhardt, Kai O, Zhou, Kefei, Johnson, Justo Sierra, Treacy, Anthony M, Lee, Jonathan, Yu, Zhigang, Borie, Dominique C

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