Search Results - "Rees, Steven D."

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein by Szewczyk, Paul, Tao, Houchao, McGrath, Aaron P., Villaluz, Mark, Rees, Steven D., Lee, Sung Chang, Doshi, Rupak, Urbatsch, Ina L., Zhang, Qinghai, Chang, Geoffrey

“…P‐glycoprotein (P‐gp) is a transporter of great clinical and pharmacological significance. Several structural studies of P‐gp and its homologs have provided…”
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Computational models in the service of X‐ray and cryo‐electron microscopy structure determination by Kryshtafovych, Andriy, Moult, John, Albrecht, Reinhard, Chang, Geoffrey A., Chao, Kinlin, Fraser, Alec, Greenfield, Julia, Hartmann, Marcus D., Herzberg, Osnat, Josts, Inokentijs, Leiman, Petr G., Linden, Sara B., Lupas, Andrei N., Nelson, Daniel C., Rees, Steven D., Shang, Xiaoran, Sokolova, Maria L., Tidow, Henning

“…Critical assessment of structure prediction (CASP) conducts community experiments to determine the state of the art in computing protein structure from amino…”
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Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure by Nicklisch, Sascha C T, Rees, Steven D, McGrath, Aaron P, Gökirmak, Tufan, Bonito, Lindsay T, Vermeer, Lydia M, Cregger, Cristina, Loewen, Greg, Sandin, Stuart, Chang, Geoffrey, Hamdoun, Amro

“…The world's oceans are a global reservoir of persistent organic pollutants to which humans and other animals are exposed. Although it is well known that these…”
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Structural basis for GPCR-independent activation of heterotrimeric Gi proteins by Kalogriopoulos, Nicholas A., Rees, Steven D., Ngo, Tony, Kopcho, Noah J., Ilatovskiy, Andrey V., Sun, Nina, Komives, Elizabeth A., Chang, Geoffrey, Ghosh, Pradipta, Kufareva, Irina

“…Heterotrimeric G proteins are key molecular switches that control cell behavior. The canonical activation of G proteins by agonist-occupied G protein-coupled…”
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Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating by Maity, Koustav, Heumann, John M., McGrath, Aaron P., Kopcho, Noah J., Hsu, Po-Kai, Lee, Chang-Wook, Mapes, James H., Garza, Denisse, Krishnan, Srinivasan, Morgan, Garry P., Hendargo, Kevin J., Klose, Thomas, Rees, Steven D., Medrano-Soto, Arturo, Saier, Milton H., Pin˜eros, Miguel, Komives, Elizabeth A., Schroeder, Julian I., Chang, Geoffrey, Stowell, Michael H. B.

“…Sensing and responding to environmental water deficiency and osmotic stresses are essential for the growth, development, and survival of plants. Recently, an…”
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Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares) by Nicklisch, Sascha C.T., Pouv, Amara K., Rees, Steven D., McGrath, Aaron P., Chang, Geoffrey, Hamdoun, Amro

“…Marine pollutants bioaccumulate at high trophic levels of marine food webs and are transferred to humans through consumption of apex species. Yellowfin tuna…”
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Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates by Zaramela, Livia S., Martino, Cameron, Alisson-Silva, Frederico, Rees, Steven D., Diaz, Sandra L., Chuzel, Léa, Ganatra, Mehul B., Taron, Christopher H., Secrest, Patrick, Zuñiga, Cristal, Huang, Jianbo, Siegel, Dionicio, Chang, Geoffrey, Varki, Ajit, Zengler, Karsten

“…Dietary habits have been associated with alterations of the human gut resident microorganisms contributing to obesity, diabetes and cancer 1 . In Western…”
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Structure of a GEM‐complexed Gai Protein Provides Novel Insights into the Emerging Human GEMiome by Kufareva, Irina, Kalogriopoulos, Nicholas, Rees, Steven D, Sun, Nina, Aznar, Nicolas, Chang, Geoffrey, Ghosh, Pradipta

“…Heterotrimeric G proteins are major signaling hubs and essential components of the signal gating machinery in eukaryotic cells. In their best‐studied capacity,…”
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Computational models in the service of X-ray and cryo-EM structure determination by Kryshtafovych, Andriy, Moult, John, Albrecht, Reinhard, Chang, Geoffrey A., Chao, Kinlin, Fraser, Alec, Greenfield, Julia, Hartmann, Marcus D., Herzberg, Osnat, Josts, Inokentijs, Leiman, Petr G., Linden, Sara B., Lupas, Andrei N., Nelson, Daniel C., Rees, Steven D., Shang, Xiaoran, Sokolova, Maria L., Tidow, Henning

“…CASP (Critical Assessment of Structure prediction) conducts community experiments to determine the state of the art in computing protein structure from amino…”
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Evaluation of Mechanisms of Non-canonical G-Protein Signaling, Membrane Transporter Dysregulation, and Bacterial Sialidase Substrate Preference Using X-Ray Crystallography by Rees, Steven D

“…X-ray crystallography remains a popular technique for achieving atomic resolution of macromolecular interactions. Protein crystal structures offer a snapshot…”
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