Search Results - "Rees, SA"

Bioanalytical strategies to support a discovery research programme by Rees, Susan A.

“…To facilitate the selection of drug candidates from a discovery research programme, a strategy was developed to assess the preliminary metabolism and…”
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Significance of Halimeda bioherms to the global carbonate budget based on a geological sediment budget for the Northern Great Barrier Reef, Australia by REES, S. A, OPDYKE, B. N, WILSON, P. A, HENSTOCK, T. J

“…Since the correlation between carbon dioxide (CO^sub 2^) levels and global temperatures was established in the ice core records, quantifying the components of…”
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Challenges and 'obstacles': reframing our perspective on the transition into adulthood for young people with life-limiting and life-threatening conditions by Pritchard, A W, Rees, S A

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Mutation analysis of POUF-1, PROP-1 and HESX-1 show low frequency of mutations in children with sporadic forms of combined pituitary hormone deficiency and septo-optic dysplasia by Rainbow, L. A., Rees, S. A., Shaikh, M. G., Shaw, N. J., Cole, T., Barrett, T. G., Kirk, J. M. W.

“…Summary Objectives  Mutations in the genes encoding the transcription factors PROP1 and POUF‐1 (Pit‐1) have been reported as common causes of combined…”
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Cardiac Cell Volume: Crystal Clear or Murky Waters? A Comparison with Other Cell Types by Wright, Anthony R., Rees, Siân A.

“…The osmolarity of bodily fluids is strictly controlled so that most cells do not experience changes in osmotic pressure under normal conditions, but osmotic…”
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Coral reef sedimentation on Rodrigues and the Western Indian Ocean and its impact on the carbon cycle by Rees, Siwan A., Opdyke, Bradley N., Wilson, Paul A., Fifield, L. Keith

“…flux associated with coral–reef growth acts as a climate change amplifier during deglaciation, adding CO…”
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Neuroblastomas with chromosome 11q loss and single copy MYCN comprise a biologically distinct group of tumours with adverse prognosis by LUTTIKHUIS, M. E. M. Oude, POWELL, J. E, REES, S. A, GENUS, T, CHUGHTAI, S, RAMANI, P, MCCONVILLE, C. M, MANN, J. R

“…Neuroblastoma is a heterogeneous tumour and its effective clinical management is dependent on accurate prognostic evaluation. In approximately 25% of patients…”
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Cell swelling and ion transport pathways in cardiac myocytes by Vandenberg, Jamie I., Rees, Siân A., Wright, Anthony R., Powell, Trevor

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( S )-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D 4 Antagonist by TenBrink, Ruth E., Bergh, Carol L., Duncan, J. Neil, Harris, Douglas W., Huff, R. M., Lahti, Robert A., Lawson, Charles F., Lutzke, Barry S., Martin, Iain J., Rees, Susan A., Schlachter, Siusaidh K., Sih, John C., Smith, Martin W.

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Linkage Analysis in Families with Recurrent Neuroblastoma by PERRI, PATRIZIA, LONGO, LUCA, McCONVILLE, CARMEL, CUSANO, ROBERTO, REES, SALLY A., SERI, MARCO, CONTE, MASSIMO, ROMEO, GIOVANNI, DEVOTO, MARCELLA, TONINI, GIAN PAOLO

“…: Neuroblastoma is a neural crest‐derived tumor of childhood with a serious prognosis; only 20% of patients with stage 4 disease survive 5 years from…”
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Specific IK1 blockade: a new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate by Rees, S A, Curtis, M J

“…The effectiveness of blockade of the inwardly rectifying K+ current (IK1) in prevention of arrhythmias is unknown. We have examined the antiarrhythmic…”
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Height screening at school: ineffective without high standards and adequate resources by Banerjee, S, Morgan, R J H, Rees, S A, Latif, A H A

“…Background: The Coventry Consensus in 1998 recommended a single height measurement of all children at school entry or around the age of 5 years and prompt…”
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Targeting ischaemia – cell swelling and drug efficacy by Wright, Anthony R, Rees, Siân A

“…Myocardial ischaemia can precipitate fatal arrhythmia, the leading cause of mortality in the western world. During ischaemia, cardiac myocytes swell rapidly…”
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Regulatory volume decrease of cardiac myocytes induced by beta-adrenergic activation of the Cl- channel in guinea pig by Wang, Z, Mitsuiye, T, Rees, S A, Noma, A

“…A new method was developed to automatically measure the thickness of a single ventricular myocyte of guinea-pig heart. A fine marker was attached on the cell's…”
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Weak linkage at 4p16 to predisposition for human neuroblastoma by PERRI, Patrizia, LONGO, Luca, TONINI, Gian Paolo, CUSANO, Roberto, MCCONVILLE, Carmel M, REES, Sally A, DEVOTO, Marcella, CONTE, Massimo, BATTISTA FERRARA, Giovanni, SERI, Marco, ROMEO, Giovanni

“…The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic…”
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Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes by Rees, S A, Vandenberg, J I, Wright, A R, Yoshida, A, Powell, T

“…Cell swelling has been shown to cause activation of a variety of cardiac sarcolemmal ionic conductances including potassium channels. The aim of this study was…”
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Extracellular osmotic pressure modulates sodium-calcium exchange in isolated guinea-pig ventricular myocytes by Wright, A R, Rees, S A, Vandenberg, J I, Twist, V W, Powell, T

“…1. The sensitivity of the cardiac Na(+)-Ca2+ exchange current to changes in osmotic pressure was investigated in guinea-pig ventricular myocytes, using the…”
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Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D 4 receptor by Schlachter, Siusaidh K, Poel, Toni J, Lawson, Charles F, Dinh, Dac M, Lajiness, Mary E, Romero, Arthur G, Rees, Susan A, Duncan, J.Neil, Smith, Martin W

“…We have discovered two substituted 4-aminopiperidine compounds having high in vitro affinity and selectivity for the human dopamine D 4 receptor. Both…”
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Exclusion of candidate genes and chromosomal regions in familial neuroblastoma by Tonini, G P, McConville, C, Cusano, R, Rees, S A, Dagnino, M, Longo, L, De Bernardi, B, Conte, M, Garaventa, A, Romeo, G, Devoto, M, Seri, M

“…Two families with recurrence of neuroblastoma one Italian and one British with three and two affected children respectively were genotyped using polymorphic…”
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Academic research: K + channels and an affair of the heart by Rees, Siǎn A.

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