Search Results - "Rees, Martin"

Cosmology and High-Energy Astrophysics: A 50-Year Perspective on Personalities, Progress, and Prospects by Rees, Martin J

“…In the 1960s, novel and increasingly powerful observational techniques opened up the field of high-energy astrophysics. Cosmology started to become an…”
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EXTRAGALACTIC STAR-FORMING GALAXIES WITH HYPERNOVAE AND SUPERNOVAE AS HIGH-ENERGY NEUTRINO AND GAMMA-RAY SOURCES: THE CASE OF THE 10 TeV NEUTRINO DATA by Senno, Nicholas, Mészáros, Peter, Murase, Kohta, Baerwald, Philipp, Rees, Martin J.

“…ABSTRACT In light of the latest IceCube data, we discuss the implications of the cosmic ray (CR) energy input from hypernovae (HNe) and supernovae (SNe) into…”
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Cancer-associated fibroblast classification in single-cell and spatial proteomics data by Cords, Lena, Tietscher, Sandra, Anzeneder, Tobias, Langwieder, Claus, Rees, Martin, de Souza, Natalie, Bodenmiller, Bernd

“…Cancer-associated fibroblasts (CAFs) are a diverse cell population within the tumour microenvironment, where they have critical effects on tumour evolution and…”
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A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer by Wagner, Johanna, Rapsomaniki, Maria Anna, Chevrier, Stéphane, Anzeneder, Tobias, Langwieder, Claus, Dykgers, August, Rees, Martin, Ramaswamy, Annette, Muenst, Simone, Soysal, Savas Deniz, Jacobs, Andrea, Windhager, Jonas, Silina, Karina, van den Broek, Maries, Dedes, Konstantin Johannes, Rodríguez Martínez, Maria, Weber, Walter Paul, Bodenmiller, Bernd

“…Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form ecosystems that determine disease progression and response to therapy…”
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A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer by Tietscher, Sandra, Wagner, Johanna, Anzeneder, Tobias, Langwieder, Claus, Rees, Martin, Sobottka, Bettina, de Souza, Natalie, Bodenmiller, Bernd

“…Immune checkpoint therapy in breast cancer remains restricted to triple negative patients, and long-term clinical benefit is rare. The primary aim of immune…”
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Donald Lynden-Bell (1935–2018) by Rees, Martin J.

“…An interview with astronomer Donald Lynden-Bell, who died in February 2018, is presented. His great-grandfather knew the famous astronomer John Herschel. His…”
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Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease by Maiocchi, Sophie L., Ku, Jacqueline, Thai, Thuan, Chan, Enoch, Rees, Martin D., Thomas, Shane R.

“…Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental component of the innate immune response against microbial pathogens. In recent…”
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Rapid Growth of High-Redshift Black Holes by Volonteri, Marta, Rees, Martin J

“…We discuss a model for the early assembly of supermassive black holes (SMBHs) at the center of galaxies that trace their hierarchical buildup far up into the…”
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Mammalian heme peroxidases: from molecular mechanisms to health implications by Davies, Michael J, Hawkins, Clare L, Pattison, David I, Rees, Martin D

“…A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil…”
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Formation of supermassive black holes by direct collapse in pre-galactic haloes by Begelman, Mitchell C., Volonteri, Marta, Rees, Martin J.

“…We describe a mechanism by which supermassive black holes (SMBHs) can form directly in the nuclei of protogalaxies, without the need for 'seed' black holes…”
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Classifying global catastrophic risks by Avin, Shahar, Wintle, Bonnie C., Weitzdörfer, Julius, Ó hÉigeartaigh, Seán S., Sutherland, William J., Rees, Martin J.

“…•A novel classification of risks according to critical system affected, global spread mechanism, and prevention and mitigation failure.•The classification…”
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The Observable Effects of a Photospheric Component on GRB and XRF Prompt Emission Spectrum by Pe’er, Asaf, Mészáros, Peter, Rees, Martin J

“…A thermal radiative component is likely to accompany the first stages of the prompt emission of gamma-ray bursts (GRBs) and X-ray flashes (XRFs). We analyze…”
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Massive Black Holes as Population III Remnants by Madau, Piero, Rees, Martin J

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Quasars at z = 6: The Survival of the Fittest by Volonteri, Marta, Rees, Martin J

“…The Sloan Digital Sky Survey has detected luminous quasars at very highredshift, z > 6. Follow-up observations indicate that at least some of these quasars are…”
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Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents by Maiocchi, Sophie L., Morris, Jonathan C., Rees, Martin D., Thomas, Shane R.

“…[Display omitted] The leukocyte-derived heme enzyme myeloperoxidase (MPO) is released extracellularly during inflammation and impairs nitric oxide (NO)…”
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The Distribution and Cosmic Evolution of Massive Black Hole Spins by Volonteri, Marta, Madau, Piero, Quataert, Eliot, Rees, Martin J

“…We study the expected distribution of massive black hole (MBH) spins and its evolution with cosmic time in the context of hierarchical galaxy formation…”
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Oxidative damage to extracellular matrix and its role in human pathologies by Rees, Martin D., Kennett, Eleanor C., Whitelock, John M., Davies, Michael J.

“…The extracellular compartments of most biological tissues are significantly less well protected against oxidative damage than intracellular sites and there is…”
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Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro by Koch, Daniel, Kho, Ay Lin, Fukuzawa, Atsushi, Alexandrovich, Alexander, Vanaanen, Kutti J, Beavil, Andrew, Pfuhl, Mark, Rees, Martin, Gautel, Mathias

“…Obscurin is a giant muscle protein (>800 kDa) featuring multiple signalling domains, including an SH3-DH-PH domain triplet from the Trio-subfamily of guanosine…”
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A New Method of Determining the Initial Size and Lorentz Factor of Gamma-Ray Burst Fireballs Using a Thermal Emission Component by Pe’er, Asaf, Ryde, Felix, Wijers, Ralph A. M. J, Mészáros, Peter, Rees, Martin J

“…In recent years, increasing evidence has emerged for a thermal component in the gamma- and X- ray spectrum of the prompt emission phase in gamma- ray bursts…”
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Radiative Transfer in a Clumpy Universe. III. The Nature of Cosmological Ionizing Sources by Madau, Piero, Haardt, Francesco, Rees, Martin J

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