Search Results - "Rees, J. K. H."

Adverse impact of bone marrow transplantation on quality of life in acute myeloid leukaemia patients: analysis of the UK Medical Research Council AML 10 Trial by Watson, M, Buck, G, Wheatley, K, Homewood, J.R, Goldstone, A.H, Rees, J.K.H, Burnett, A.K

“…The increasing success of intensive consolidation chemotherapy (CCT) as an alternative to bone marrow transplant (BMT) in acute myeloid leukaemia (AML)…”
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Features affecting outcome during remission induction of acute myeloid leukaemia in 619 adult patients by Swirsky, D M, de Bastos, M, Parish, S E, Rees, J K, Hayhoe, F G

“…Six hundred and nineteen patients with de novo acute myeloid leukaemia, entered into the Medical Research Council's eighth trial of therapy have been studied…”
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A simple, robust, validated and highly predictive index for the determination of risk‐directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial by Wheatley, Keith, Burnett, Alan K., Goldstone, Anthony H., Gray, Richard G., Hann, Ian M., Harrison, Christine J., Rees, John K. H., Stevens, Richard F., Walker, Helen

“…Data on 1711 patients, aged up to 55 years, in the MRC AML 10 trial were used to create a prognostic index for use in risk‐directed therapy decision making for…”
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Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial by Burnett, Alan K, Goldstone, Anthony H, Stevens, Richard MF, Hann, Ian M, Rees, John KH, Gray, Richard G, Wheatley, Keith

“…Three strategies are used to prevent relapse in patients with acute myeloid leukaemia in first remission. Most of those with suitable donors are offered…”
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Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10) by HANN, I. M, STEVENS, R. F, GOLDSTONE, A. H, REES, J. K. H, WHEATLEY, K, GRAY, R. G, BURNETT, A. K

“…The relative efficacy and toxicity of the chemotherapeutic agents thioguanine (6TG) and etoposide (VP16) were assessed by a randomized comparison of the DAT…”
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Retinoic acid alone and in combination with cytosine arabinoside induces differentiation of human myelomonocytic and monoblastic leukaemic cells by Hassan, H T, Rees, J K

“…The effect of retinoic acid (RA) alone and in combination with cytosine arabinoside (Ara-C) on differentiation of fresh human myeloid leukaemic cells from…”
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Terminal deoxynucleotidyl transferase and HLA-DR expression appear unrelated to prognosis of acute myeloid leukaemia by Swirsky, D M, Greaves, M F, Gray, R G, Rees, J K

“…Mononuclear cells from peripheral blood or bone marrow from 314 patients with acute myeloid leukaemia were examined for the presence of nuclear terminal…”
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Triple combination of retinoic acid + low concentration of cytosine arabinoside + hexamethylene bisacetamide induces differentiation of human AML blasts in primary culture by Hassan, H T, Rees, J K

“…Differentiation induction therapy provides an alternative therapeutic approach for patients with acute myeloid leukemia (AML) who are either unsuitable for or…”
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New synergistic combinations of differentiation inducing agents in the treatment of acute myeloid leukaemia by HASSAN, H. T, ZYADA, L. E, RAGAB, M. H, REES, J. K. H

“…Differentiation inducing agents in double and triple combinations can induce differentiation in primary culture of more than 80% of blast cells from some AML…”
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Remission induction and postremission therapy in acute myelogenous leukemia: British MRC Study by Rees, J K, Gray, R G

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The relation between hypocholesterolemia and degree of maturation in acute myeloid leukemia by Zyada, L E, Hassan, H T, Rees, J K, Ragab, M H

“…Plasma cholesterol concentrations were determined in 83 acute myeloid leukemia patients. Mean plasma cholesterol concentration (+/- S.D.) at the time of…”
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Calciphylaxis in Man by Rees, J. K. H., Coles, G. A.

“…A patient with renal failure developed widespread calcification in the thighs after the injection of iron-dextran (Imferon). This is considered as an example…”
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Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts by Borrow, J, Goddard, A D, Gibbons, B, Katz, F, Swirsky, D, Fioretos, T, Dube, I, Winfield, D A, Kingston, J, Hagemeijer, A

“…Acute promyelocytic leukaemia (APL; AML M3) is identified by a unique t(15;17) translocation which fuses the PML gene to the retinoic acid receptor alpha gene…”
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Low concentrations of cytosine arabinoside, 6-thioguanine, actinomycin-D and aclacinomycin A stimulates the differentiation of normal human marrow myeloid progenitor cells by Hassan, H T, Rees, J K

“…Myelosuppression is the major side effect of most anticancer cytotoxic drugs. Low concentrations of cytosine arabinoside (Ara-C), 6-thioguanine (6-Th),…”
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Chemotherapy versus transplants for acute myelogenous leukemia in second remission by Gale, R P, Horowitz, M M, Rees, J K, Gray, R G, Oken, M M, Estey, E H, Kim, K M, Zhang, M J, Ash, R C, Atkinson, K, Champlin, R E, Dicke, K A, Gajewski, J L, Goldman, J M, Helbig, W, Henslee-Downey, P S, Hinterberger, W, Jacobsen, N, Keating, A, Klein, J P, Marmont, A M, Prentice, H G, Reiffers, J, Rimm, A A, Bortin, M M

“…The best therapy for persons with acute myelogenous leukemia (AML) in 2nd remission is unknown. Bone marrow transplants from an HLA-identical sibling are…”
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Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay by Twentyman, P R, Fox, N E, Rees, J K

“…We have determined the feasibility of using the MTT colorimetric assay for measuring the sensitivity of fresh leukaemia cells to cytotoxic agents. A linear…”
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AML associated with previous cytotoxic therapy, MDS or myeloproliferative disorders: results from the MRC's 9th AML trial by Hoyle, C F, de Bastos, M, Wheatley, K, Sherrington, P D, Fischer, P J, Rees, J K, Gray, R, Hayhoe, F G

“…The outcome of treatment with standard first line therapy of 66 patients with acute myeloid leukaemia (AML) secondary to preceding chemotherapy (Group 1), a…”
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8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features by Swirsky, D M, Li, Y S, Matthews, J G, Flemans, R J, Rees, J K, Hayhoe, F G

“…Thirty patients with the 8;21 translocation and three with closely related variants have been studied. Ages ranged from 3 to 64 years (mean 28.3). Thirty-one…”
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Evaluation of Stem Cell Transplantation in AML by Burnett, Alan K., Goldstone, A., Hann, I., Stevens, R., Rees, J. K. H., Wheatley, K.

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Resistance circumvention strategies tested in clinical leukaemia specimens using the MTT colorimetric assay by Lambert, E, Rees, J K, Twentyman, P R

“…We have used a 4-day MTT colorimetric assay to study drug sensitivity of leucocytes from leukaemia patients and from normal donors. Response to Adriamycin,…”
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