Search Results - "Rees, Gareth D"

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction by England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne

“…Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for…”
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A simeprevir-inducible molecular switch for the control of cell and gene therapies by Chin, Stacey E., Schindler, Christina, Vinall, Lisa, Dodd, Roger B., Bamber, Lisa, Legg, Sandrine, Sigurdardottir, Anna, Rees, D. Gareth, Malcolm, Tim I. M., Spratley, Samantha J., Granéli, Cecilia, Sumner, Jonathan, Tigue, Natalie J.

“…Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant…”
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Chitosan microparticles for the controlled delivery of fluoride by Keegan, Gemma M, Smart, John D, Ingram, Matthew J, Barnes, Lara-Marie, Burnett, Gary R, Rees, Gareth D

“…Abstract Objectives To manufacture and characterise chitosan/fluoride microparticles prepared by spray drying and assess their utility as controlled release…”
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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding by Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz

“…Affinity- and stability-engineered variants of CTLA4-Ig fusion molecules with enhanced pharmacokinetic profiles could yield improved therapies with the…”
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Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes by Taylor, Jonathan D., Barrett, Nathalie, Martinez Cuesta, Sergio, Cassidy, Katelyn, Pachl, Fiona, Dodgson, James, Patel, Radhika, Eriksson, Tuula M., Riley, Aidan, Burrell, Matthew, Bauer, Christin, Rees, D. Gareth, Cimbro, Raffaello, Zhang, Andrew X., Minter, Ralph R., Hunt, James, Legg, Sandrine

“…Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of…”
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Microemulsion-based media as novel drug delivery systems by Lawrence, M. Jayne, Rees, Gareth D.

“…Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently…”
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Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding by Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz

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Interactions between dodecyl phosphates and hydroxyapatite or tooth enamel: relevance to inhibition of dental erosion by Jones, Siân B, Barbour, Michele E, Shellis, R Peter, Rees, Gareth D

“…Tooth surface modification is a potential method of preventing dental erosion, a form of excessive tooth wear facilitated by softening of tooth surfaces…”
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MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential by Tigue, Natalie J., Bamber, Lisa, Andrews, John, Ireland, Samantha, Hair, James, Carter, Edward, Sridharan, Sudharsan, Jovanović, Jelena, Rees, D. Gareth, Springall, Jeremy S., Solier, Emilie, Li, Yi-Ming, Chodorge, Matthieu, Perez-Martinez, David, Higazi, Daniel R., Oberst, Michael, Kennedy, Maureen, Black, Chelsea M., Yan, Li, Schwickart, Martin, Maguire, Shaun, Cann, Jennifer A., de Haan, Lolke, Young, Lesley L., Vaughan, Tristan, Wilkinson, Robert W., Stewart, Ross

“…Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation…”
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Affinity maturation of phage display antibody populations using ribosome display by Groves, Maria, Lane, Steven, Douthwaite, Julie, Lowne, David, Gareth Rees, D., Edwards, Bryan, Jackson, Ronald H.

“…A comparison has been performed, using phage display or ribosome display, of stringent selections on antibody populations derived from three rounds of phage…”
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1169 AZD5863: a specific, potent, affinity-optimized claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing by Gaspar, Miguel, Natoli, Marina, Castan, Laure, Rahmy, Sharif, Kelton, Cathryn, Mulgrew, Kathy, Korade, Martin, Huhn, Oisin, Gareth Rees, D, Sigurdardottir, Anna, Lloyd, Christopher, He, Yun, Rong, Yiping, Pollizzi, Kristen, Hammond, Scott, Cemerski, Saso, Dovedi, Simon, Cobbold, Mark, Ridgway, Benjamin, Broggi, Maria AS, Palmer, Douglas C, Ball, Kathryn, McFarlane, Mary, Vargas, Fred Arce, Ceaicovscaia, Natalia, Pouliot, Gayle, Szekeres, Philip, Fitzgerald, Jonathan, Kumar, Rakesh

“…BackgroundClaudin 18.2 (CLDN18.2), a tetraspanin family member essential for the formation of tight junctions,1 is highly expressed in gastric, pancreatic and…”
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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma by Cohen, E Suzanne, Dobson, Claire L, Käck, Helena, Wang, Bing, Sims, Dorothy A, Lloyd, Christopher O, England, Elizabeth, Rees, D Gareth, Guo, Hongwei, Karagiannis, Sophia N, O'Brien, Siobhan, Persdotter, Sofia, Ekdahl, Helena, Butler, Robin, Keyes, Feenagh, Oakley, Sarah, Carlsson, Mats, Briend, Emmanuel, Wilkinson, Trevor, Anderson, Ian K, Monk, Phillip D, von Wachenfeldt, Karin, Eriksson, Per-Olof F, Gould, Hannah J, Vaughan, Tristan J, May, Richard D

“…The critical role played by IgE in allergic asthma is well-documented and clinically precedented, but some patients in whom IgE neutralization may still offer…”
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Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential by Kockisch, Sandra, Rees, Gareth D, Young, Simon A, Tsibouklis, John, Smart, John D

“…Polymeric microparticles were fabricated from Carbopol, polycarbophil, chitosan, or Gantrez using a "water-in-oil emulsification" solvent evaporation method…”
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Fluoropolymers as low-surface-energy tooth coatings for oral care by Churchley, David, Rees, Gareth D., Barbu, Eugen, Nevell, Thomas G., Tsibouklis, John

“…A range of low-surface-energy fluoropolymers has been synthesised and their effectiveness as dental-care coatings for plaque, stain and erosion prevention has…”
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Control of brushing variables for the in vitro assessment of toothpaste abrasivity using a novel laboratory model by Parry, Jason, Harrington, Edward, Rees, Gareth D, McNab, Rod, Smith, Anthony J

“…Abstract Objectives Design and construct a tooth-brushing simulator incorporating control of brushing variables including brushing force, speed and…”
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In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region by Skamaki, Kalliopi, Emond, Stephane, Chodorge, Matthieu, Andrews, John, Rees, D. Gareth, Cannon, Daniel, Popovic, Bojana, Buchanan, Andrew, Minter, Ralph R., Hollfelder, Florian

“…We report a systematic combinatorial exploration of affinity enhancement of antibodies by insertions and deletions (InDels). Transposon-based introduction of…”
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Novel quartz crystal microbalance based biosensor for detection of oral epithelial cell–microparticle interaction in real-time by Elsom, Jacqueline, Lethem, Michael I., Rees, Gareth D., Hunter, A. Christy

“…Recent applications of quartz crystal resonant sensor technology to monitor cell adhesion and specific ligand interaction processes has triggered the…”
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Formation and Morphology of Calcium Sulfate Nanoparticles and Nanowires in Water-in-Oil Microemulsions by Rees, Gareth D, Evans-Gowing, Richard, Hammond, Stephen J, Robinson, Brian H

“…Nanosized insoluble metal sulfate aggregates, predominantly CaSO4, have been prepared in a variety of water-in-oil (w/o) microemulsions stabilized by either…”
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation by Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas

“…In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little…”
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Robust Prediction of Relative Binding Energies for Protein–Protein Complex Mutations Using Free Energy Perturbation Calculations by Sampson, Jared M., Cannon, Daniel A., Duan, Jianxin, Epstein, Jordan C.K., Sergeeva, Alina P., Katsamba, Phinikoula S., Mannepalli, Seetha M., Bahna, Fabiana A., Adihou, Hélène, Guéret, Stéphanie M., Gopalakrishnan, Ranganath, Geschwindner, Stefan, Rees, D. Gareth, Sigurdardottir, Anna, Wilkinson, Trevor, Dodd, Roger B., De Maria, Leonardo, Mobarec, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Buchanan, Andrew, Friesner, Richard A., Wang, Lingle

“…[Display omitted] •Reliable calculation of relative binding free energy changes for most protein mutations to within ∼1 kcal/mol.•Automated Protein FEP+ Groups…”
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