Search Results - "Rees, Anthony"

Understanding the human antibody repertoire by Rees, Anthony R

“…The origins of the various elements in the human antibody repertoire have been and still are subject to considerable uncertainty. Uncertainty in respect of…”
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Current strategies for detecting functional convergence across B-cell receptor repertoires by Raybould, Matthew I. J., Rees, Anthony R., Deane, Charlotte M.

“…Convergence across B-cell receptor (BCR) and antibody repertoires has become instrumental in prioritizing candidates in recent rapid therapeutic antibody…”
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Studies on the Internalization Mechanism of Cationic Cell-penetrating Peptides by Drin, Guillaume, Cottin, Sylvine, Blanc, Emmanuelle, Rees, Anthony R., Temsamani, Jamal

“…A great deal of data has been amassed suggesting that cationic peptides are able to translocate into eucaryotic cells in a temperature-independent manner…”
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Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries by Kecili, Rustem, Billing, Johan, Nivhede, David, Sellergren, Börje, Rees, Anthony, Yilmaz, Ecevit

“…•Removal of aminopyridines can be achieved by using molecularly imprinted polymers.•MIPs are effective adsorbents for GTI removal from model API solutions.•A…”
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Extracting human antibody sequences from public databases for antibody humanization: high frequency of species assignment errors by Martin, Andrew C.R., Rees, Anthony R.

“…Abstract In antibody humanization, complementarity determining regions from a ‘donor’ antibody are often grafted onto a human framework selected by high…”
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Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering by Pelat, Thibaut, Bedouelle, Hugues, Rees, Anthony R., Crennell, Susan J., Lefranc, Marie-Paule, Thullier, Philippe

“…Fab 35PA83 is an antibody fragment of non-human primate origin that neutralizes the anthrax lethal toxin. Human antibodies are usually preferred when clinical…”
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Age and growth in southern bluefin tuna, Thunnus maccoyii (Castelnau): Direct estimation from otoliths, scales and vertebrae by Gunn, John S., Clear, Naomi P., Carter, Thor I., Rees, Anthony J., Stanley, Clive A., Farley, Jessica H., Kalish, John M.

“…In the early 1990s, the spawning biomass of the southern bluefin tuna (SBT) population was estimated to be less than 10% of its historical level. However,…”
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Direct aqueous supercritical fluid extraction coupled on-line with liquid chromatography–tandem mass spectrometry for the analysis of polyether ionophore antibiotics in water by Ramsey, Edward D., Rees, Anthony T., Wei, Guo, Liu, Jing Y., Wu, Xiu H.

“…A direct aqueous SFE system designed to extract water samples contained in vials has been coupled on-line with a reverse phase LC–MS–MS system using a single…”
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Trifluoroethanol may form a solvent matrix for assisted hydrophobic interactions between peptide side chains by Reiersen, Herald, Rees, Anthony R.

“…Several models for interactions between trifluoroethanol (TFE) and peptides and proteins have recently been proposed, but none have been able to rationalize…”
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Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy by Rousselle, Christophe, Clair, Philippe, Smirnova, Maria, Kolesnikov, Yuri, Pasternak, Gavril W, Gac-Breton, Stephanie, Rees, Anthony R, Scherrmann, Jean-Michel, Temsamani, Jamal

“…The blood-brain barrier restricts the passage of substances into the brain. Neuropeptides, such as enkephalins, cannot be delivered into the brain when given…”
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Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria by Hansson, Magnus J., Persson, Tanja, Friberg, Hans, Keep, Marcus F., Rees, Anthony, Wieloch, Tadeusz, Elmér, Eskil

“…The mitochondrial permeability transition (mPT) is considered to be an important mediator of apoptosis and necrosis, and is specifically blocked by cyclosporin…”
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WAM: an improved algorithm for modelling antibodies on the WEB by Whitelegg, Nicholas R.J., Rees, Anthony R.

“…An improved antibody modelling algorithm has been developed which incorporates significant improvements to the earlier versions developed by Martin et al…”
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Antibody variable regions: toward a unified modeling method by Whitelegg, Nicholas, Rees, Anthony R

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COVID-19 and vaccine development by Rees, Anthony

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Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy by Temsamani, Jamal, Bonnafous, Cécile, Rousselle, Christophe, Fraisse, Yannik, Clair, Philippe, Granier, Luc-André, Rees, Anthony R, Kaczorek, Michel, Scherrmann, Jean-Michel

“…Morphine-6-glucuronide (M6G), an active metabolite of morphine, has been shown to have significantly attenuated brain penetration relative to that of morphine…”
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Studies towards enantioselective surface imprinted polymers by Yilmaz, Ecevit, Billing, Johan, Boyd, Brian, Möller, Per, Rees, Anthony

“…Molecularly imprinted polymers (MIPs) are tailor-made materials that can specifically rebind desired target molecules. Usually, the template is in solution…”
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Viruses, vaccines and cardiovascular effects by Rees, Anthony R

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Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors by Drin, Guillaume, Rousselle, Christophe, Scherrmann, Jean-Michel, Rees, Anthony R, Temsamani, Jamal

“…Biological membranes normally restrict the passage of hydrophilic molecules. This impairs the use of a wide variety of drugs for biomedical applications. To…”
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Microreactors for oxidations using fluorine by Chambers, Richard D, Holling, Darren, Rees, Anthony J, Sandford, Graham

“…Continuous flow gas–liquid thin film microreactors have been effectively used for the oxidation of alcohols and Baeyer–Villiger oxidation of ketones using…”
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Short elastin-like peptides exhibit the same temperature-induced structural transitions as elastin polymers: implications for protein engineering by Reiersen, Herald, Clarke, Anthony R, Rees, Anthony R

“…Elastin is a major protein component of the vascular wall and is responsible for its unusual elastic properties. Polymers of its repeating VPGVG sequences have…”
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