Search Results - "Reenan, Robert A."

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells by Juliano, Celina E., Reich, Adrian, Na Liu, Götzfried, Jessica, Zhong, Mei, Uman, Selen, Reenan, Robert A., Wessel, Gary M., Steele, Robert E., Lin, Haifan

“…PIWI proteins and their bound PIWI-interacting RNAs (piRNAs) are found in animal germlines and are essential for fertility, but their functions outside of the…”
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Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan by Silvestrini, Melissa J., Johnson, Joseph R., Kumar, Anita V., Thakurta, Tara G., Blais, Karine, Neill, Zachary A., Marion, Sarah W., St. Amand, Victoria, Reenan, Robert A., Lapierre, Louis R.

“…Transcriptional modulation of the process of autophagy involves the transcription factor HLH-30/TFEB. In order to systematically determine the regulatory…”
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Dynamic response of RNA editing to temperature in Drosophila by Rieder, Leila E, Savva, Yiannis A, Reyna, Matthew A, Chang, Yao-Jen, Dorsky, Jacquelyn S, Rezaei, Ali, Reenan, Robert A

“…Adenosine-to-inosine RNA editing is a highly conserved process that post-transcriptionally modifies mRNA, generating proteomic diversity, particularly within…”
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The intricate relationship between RNA structure, editing, and splicing by Rieder, Leila E., Reenan, Robert A.

“…► The structure of an RNA editing substrate dictates which adenosine is targeted. ► Splicing and RNA editing may compete for access to the transcript. ► Most…”
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Identification of alternative splicing regulators by RNA interference in Drosophila by Park, J.W, Parisky, K, Celotto, A.M, Reenan, R.A, Graveley, B.R

“…Alternative splicing is thought to be regulated by nonspliceosomal RNA binding proteins that modulate the association of core components of the spliceosome…”
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Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible by McKerrow, Wilson H, Savva, Yiannis A, Rezaei, Ali, Reenan, Robert A, Lawrence, Charles E

“…Repetitive elements are now known to have relevant cellular functions, including self-complementary sequences that form double stranded (ds) RNA. There are…”
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A-to-I Pre-mRNA Editing in Drosophila Is Primarily Involved in Adult Nervous System Function and Integrity by Palladino, Michael J, Keegan, Liam P, O'Connell, Mary A, Reenan, Robert A

“…Specific A-to-I RNA editing, like that seen in mammals, has been reported for several Drosophila ion channel genes. Drosophila possesses a candidate editing…”
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Adenosine-to-Inosine Genetic Recoding Is Required in the Adult Stage Nervous System for Coordinated Behavior in Drosophila by Jepson, James E.C., Reenan, Robert A.

“…Adenosine deaminases acting on RNA (ADARs) catalyze the deamination of adenosine to inosine in double-stranded RNA templates, a process known as RNA editing…”
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Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion by Zhu, Chen-Tseh, Chang, Chengyi, Reenan, Robert A, Helfand, Stephen L

“…Natural selection acts to maximize reproductive fitness. However, antagonism between life span and reproductive success frequently poses a dilemma pitting the…”
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Circuit Dysfunction in SOD1-ALS Model First Detected in Sensory Feedback Prior to Motor Neuron Degeneration Is Alleviated by BMP Signaling by Held, Aaron, Major, Paxton, Sahin, Asli, Reenan, Robert A, Lipscombe, Diane, Wharton, Kristi A

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which the origin and underlying cellular defects are not fully understood…”
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Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila by St Laurent, Georges, Tackett, Michael R, Nechkin, Sergey, Shtokalo, Dmitry, Antonets, Denis, Savva, Yiannis A, Maloney, Rachel, Kapranov, Philipp, Lawrence, Charles E, Reenan, Robert A

“…The accurate and thorough genome-wide detection of A-to-I editing has proven technically challenging. Using a combination of computational prediction and…”
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RNA editing in eag potassium channels: Biophysical consequences of editing a conserved S6 residue by Ryan, Mary Y., Maloney, Rachel, Fineberg, Jeffrey D., Reenan, Robert A., Horn, Richard

“…RNA editing at four sites in eag, a Drosophila voltage-gated potassium channel, results in the substitution of amino acids into the final protein product that…”
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ADAR protein family by Savva, Yiannis A, Rieder, Leila E, Reenan, Robert A

“…Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which adenosines are selectively converted to inosines in double-stranded RNA…”
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Effect of sodium channel abundance on Drosophila development, reproductive capacity and aging by Garber, Graham, Smith, Lee Ann, Reenan, Robert A., Rogina, Blanka

“…The voltage-gated Na + channels (VGSC) are complex membrane proteins responsible for generation and propagation of the electrical signals through the brain,…”
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Tertiary structural elements determine the extent and specificity of messenger RNA editing by Rieder, Leila E., Staber, Cynthia J., Hoopengardner, Barry, Reenan, Robert A.

“…The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA…”
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Tuning of RNA editing by ADAR is required in Drosophila by Keegan, Liam P, Brindle, James, Gallo, Angela, Leroy, Anne, Reenan, Robert A, O'Connell, Mary A

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Mutations to the piRNA pathway component aubergine enhance meiotic drive of segregation distorter in Drosophila melanogaster by Gell, Selena L, Reenan, Robert A

“…Diploid sexual reproduction involves segregation of allelic pairs, ensuring equal representation of genotypes in the gamete pool. Some genes, however, are able…”
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Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein by Bhogal, Balpreet, Jepson, James E, Savva, Yiannis A, Pepper, Anita S-R, Reenan, Robert A, Jongens, Thomas A

“…Loss of FMR1 gene function results in fragile X syndrome. Here, the authors demonstrate that the Drosophila fragile X homolog dFMR1 is involved in the RNA…”
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Unraveling pleiotropic functions of A-To-I RNA editing in Drosophila by Jepson, James E., Reenan, Robert A.

“…In metazoan cells, transcripts that fold into double-strand RNA structures are endowed with the capacity to undergo A-to-I RNA editing, during which adenosines…”
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Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis by Yanagi, Katherine S., Wu, Zhijin, Amaya, Joshua, Chapkis, Natalie, Duffy, Amanda M., Hajdarovic, Kaitlyn H., Held, Aaron, Mathur, Arjun D., Russo, Kathryn, Ryan, Veronica H., Steinert, Beatrice L., Whitt, Joshua P., Fallon, Justin R., Fawzi, Nicolas L., Lipscombe, Diane, Reenan, Robert A., Wharton, Kristi A., Hart, Anne C.

“…•Genetic modifiers contribute to phenotypic variability of ALS.•Created a comprehensive list of known ALS genetic modifiers.•Bioinformatic analysis and shared…”
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