Search Results - "Reele, SB"

Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics by Grimm, Scott W., Richtand, Neil M., Winter, Helen R., Stams, Karen R., Reele, Stots B.

“…Aims To explore the potential for drug interactions on quetiapine pharmacokinetics using in vitro and in vivo assessments. Methods The CYP enzymes responsible…”
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Total suppression of ventricular arrhythmias by encainide. Pharmacokinetic and electrocardiographic characteristics by Roden, D M, Reele, S B, Higgins, S B, Mayol, R F, Gammans, R E, Oates, J A, Woosley, R L

“…We studied the antiarrhythmic effect of a range of oral doses of encainide in 11 patients with stable high-frequency ventricular arrhythmias. Total suppression…”
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Gastric antisecretory activity of arbaprostil as affected by gastric pH by REELE, S. B

“…Arbaprostil [15(R),15-methyl prostaglandin E2] is inactive. In the presence of acid it is converted to the active 15(S) configuration. The degree of acidity…”
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Oral antisecretory activity of prostaglandin E2 in man by REELE, S. B, BOHAN, D

“…We studied the oral gastric antisecretory activity of prostaglandin E2 in three groups of six normal volunteers. Each volunteer was studied twice, once after…”
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Dose response inhibition in man of meal-stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally by Robert, A, Kane, G, Reele, S B

“…15(R)-15-methyl prostaglandin E2 was given orally to healthy male volunteers. Thirty minutes later a 10% peptone meal was introduced into the stomach, and the…”
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Arbaprostil (15(R)‐15‐methyl PGE2): lack of effect on theophylline metabolism by Reele, SB, Euler, A., McEvers, J., Metzler, C.

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Reassessment of dapsone as a marker of acetylator phenotypes by Wiggan, E B, Dennis, S, Reele, S B, Luke, D R

“…The ratio of metabolite to parent dapsone concentrations at 3 hours after dosing has been used as a marker of acetylator phenotypes. The absorption of dapsone…”
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Evaluation of methods of administering tyramine to raise systolic blood pressure by Pace, D G, Reele, S B, Rozik, L M, Rogers-Phillips, C A, Dabice, J A, Givens, S V

“…To compare the relative merits of two different administration regimens, tyramine was administered intravenously in ascending doses to 12 healthy subjects to…”
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The effect of trimoprostil (trimethyldesoxy prostaglandin E2) on the intrauterine pressure in women by Reele, S B, Nauss-Karol, C, Lusaitis, A A, Passe, S M

“…Prostaglandin E2 is uterotonic. Trimoprostil, a prostaglandin E2 analog, is a gastric antisecretory and cytoprotective agent. The effects of single doses of 0,…”
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Absence of cardiac arrhythmias during a very-low-calorie diet with high biological quality protein by Linet, O I, Butler, D, Caswell, K, Metzler, C, Reele, S B

“…Fourteen women who were at least 50 lb (22.7 kg) overweight entered the 15 week study which included 4 weeks of 1200 cal (5028 J) balanced diet followed by 7…”
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Sorbitol induced diarrheal illness model by Reele, S B, Chodos, D J

“…Twenty-five normal volunteers participated in this study to develop a model of diarrheal illness. The ideal model would induce diarrhea with consistent onset…”
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The effects of continuous infusions of prostacyclin-Na (epoprostenol-sodium) on platelet counts, ADP-induced aggregation, and cyclic AMP levels in normal volunteers by Reele, S B, Miller, O V, Spillers, C, Gorman, R R

“…Six male volunteers received either 0 (buffer), 2.5 or 5.0 ng/kg/min PGI2 X Na for 72 hrs. Various platelet parameters were monitored for an additional 72 hrs…”
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Tocainide therapy for refractory ventricular arrhythmias by Roden, D M, Reele, S B, Higgins, S B, Carr, R K, Smith, R F, Oates, J A, Woosley, R L

“…Tocainide, a congener of lidocaine, was used to treat symptomatic ventricular arrhythmias in 19 patients resistant to or unable to tolerate conventional…”
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Pharmacologic reversal of hypotensive effect complicating antiarrhythmic therapy with bretylium by Woosley, R L, Reele, S B, Roden, D M, Nies, A S, Oates, J A

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Antiarrhythmic effects of the quaternary propranolol analog that does not induce beta-adrenergic blockade by Reele, S B, Kornhauser, D, Shand, D, Carr, K, Oates, J A, Woosley, R L

“…Pranolium chloride (dimethylpropranolol chloride) is a nonbeta blocking quaternary ammonium that has structural similarities to propranolol and bretylium that…”
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Aspirin-induced damage in the dog Heidenhain pouch and cytoprotection with 16,16-dimethyl PGE2 by Reele, S B, Gumbleton, T J, Stryd, R P, Brunden, M N, Gilbertson, T J

“…The gastric mucosa of animals and man can be damaged by noxious agents and protected by prostaglandins. We developed a Heidenhain pouch dog model which allows…”
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Recurrent ventricular tachycardia in the absence of overt heart disease: clinical characteristics and response to drug therapy by Roden, D M, Duff, H J, Reele, S B, Woosley, R L, Oates, J A, Smith, R F, Friesinger, G C

“…Eight patients, seven of them women, have been followed up for a mean of 8.1 years (range, three to 18) with the uncommon syndrome of recurrent frequent…”
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Gastrointestinal propulsion measurement with radiopaque capsules during 16,16-dimethyl PGE2 infusion by Reele, S B, Ruwart, M J, Noah, M L

“…A method to quantitate gastric emptying (GE) and small intestinal transit (SIT) by obtaining serial abdominal x-rays after administration of radiopaque…”
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Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients by Rios, A, Stringfellow, D A, Fitzpatrick, F A, Reele, S B, Gutknecht, G D, Hersh, E M

“…2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) was given to 59 patients in a Phase I study. The agent was selected because it is an interferon inducer and…”
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