Search Results - "Reele, S. B."

Effect of a high-fat meal on the pharmacokinetics of dapagliflozin, a selective SGLT2 inhibitor, in healthy subjects by Kasichayanula, S., Liu, X., Zhang, W., Pfister, M., Reele, S. B., Aubry, A.-F., LaCreta, F. P., Boulton, D. W.

“…Dapagliflozin is a potent and selective inhibitor of sodium–glucose co‐transporter type 2 that is being developed for the treatment of type 2 diabetes…”
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Gastric antisecretory activity of arbaprostil as affected by gastric pH by REELE, S. B

“…Arbaprostil [15(R),15-methyl prostaglandin E2] is inactive. In the presence of acid it is converted to the active 15(S) configuration. The degree of acidity…”
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Oral antisecretory activity of prostaglandin E2 in man by REELE, S. B, BOHAN, D

“…We studied the oral gastric antisecretory activity of prostaglandin E2 in three groups of six normal volunteers. Each volunteer was studied twice, once after…”
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Reassessment of dapsone as a marker of acetylator phenotypes by Wiggan, E B, Dennis, S, Reele, S B, Luke, D R

“…The ratio of metabolite to parent dapsone concentrations at 3 hours after dosing has been used as a marker of acetylator phenotypes. The absorption of dapsone…”
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Absence of cardiac arrhythmias during a very-low-calorie diet with high biological quality protein by Linet, O I, Butler, D, Caswell, K, Metzler, C, Reele, S B

“…Fourteen women who were at least 50 lb (22.7 kg) overweight entered the 15 week study which included 4 weeks of 1200 cal (5028 J) balanced diet followed by 7…”
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Sorbitol induced diarrheal illness model by Reele, S B, Chodos, D J

“…Twenty-five normal volunteers participated in this study to develop a model of diarrheal illness. The ideal model would induce diarrhea with consistent onset…”
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Electrophysiological effects of high-dose propranolol in dogs: evidence in vivo for effects not mediated by the beta adrenoceptor by Dawson, A K, Reele, S B, Wood, A J, Duff, H J, Woosley, R L, Smith, R F

“…Closed-chest dogs anesthetized with morphine and chloralose were studied to determine if direct or nonspecific cardiac electro-physiological effects of…”
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Dose response inhibition in man of meal-stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally by Robert, A, Kane, G, Reele, S B

“…15(R)-15-methyl prostaglandin E2 was given orally to healthy male volunteers. Thirty minutes later a 10% peptone meal was introduced into the stomach, and the…”
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Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model by Kimko, Hui C., Reele, Stots S. B., Holford, Nicholas H. G., Peck, Carl C.

“…A completed phase 3 trial result was simulated 100 times on the basis of a simulation model of quetiapine fumarate (Seroquel), an antischizophrenic agent. The…”
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The effects of continuous infusions of prostacyclin-Na (epoprostenol-sodium) on platelet counts, ADP-induced aggregation, and cyclic AMP levels in normal volunteers by Reele, S B, Miller, O V, Spillers, C, Gorman, R R

“…Six male volunteers received either 0 (buffer), 2.5 or 5.0 ng/kg/min PGI2 X Na for 72 hrs. Various platelet parameters were monitored for an additional 72 hrs…”
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Lack of effect of arbaprostil on the human non-pregnant uterus by Reele, S B, Euler, A R, Hanover, C K, Lookabaugh, J L

“…Arbaprostil ((15R)-15-methyl Prostaglandin E2) is being studied for the treatment of gastrointestinal illness. To determine its effect on the human uterus,…”
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Arbaprostil (15(R)‐15‐methyl PGE2): lack of effect on theophylline metabolism by Reele, SB, Euler, A., McEvers, J., Metzler, C.

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Evaluation of methods of administering tyramine to raise systolic blood pressure by Pace, D G, Reele, S B, Rozik, L M, Rogers-Phillips, C A, Dabice, J A, Givens, S V

“…To compare the relative merits of two different administration regimens, tyramine was administered intravenously in ascending doses to 12 healthy subjects to…”
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The effect of trimoprostil (trimethyldesoxy prostaglandin E2) on the intrauterine pressure in women by Reele, S B, Nauss-Karol, C, Lusaitis, A A, Passe, S M

“…Prostaglandin E2 is uterotonic. Trimoprostil, a prostaglandin E2 analog, is a gastric antisecretory and cytoprotective agent. The effects of single doses of 0,…”
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Tocainide therapy for refractory ventricular arrhythmias by Roden, D M, Reele, S B, Higgins, S B, Carr, R K, Smith, R F, Oates, J A, Woosley, R L

“…Tocainide, a congener of lidocaine, was used to treat symptomatic ventricular arrhythmias in 19 patients resistant to or unable to tolerate conventional…”
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Antiarrhythmic effects of the quaternary propranolol analog that does not induce beta-adrenergic blockade by Reele, S B, Kornhauser, D, Shand, D, Carr, K, Oates, J A, Woosley, R L

“…Pranolium chloride (dimethylpropranolol chloride) is a nonbeta blocking quaternary ammonium that has structural similarities to propranolol and bretylium that…”
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Aspirin-induced damage in the dog Heidenhain pouch and cytoprotection with 16,16-dimethyl PGE2 by Reele, S B, Gumbleton, T J, Stryd, R P, Brunden, M N, Gilbertson, T J

“…The gastric mucosa of animals and man can be damaged by noxious agents and protected by prostaglandins. We developed a Heidenhain pouch dog model which allows…”
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Gastrointestinal propulsion measurement with radiopaque capsules during 16,16-dimethyl PGE2 infusion by Reele, S B, Ruwart, M J, Noah, M L

“…A method to quantitate gastric emptying (GE) and small intestinal transit (SIT) by obtaining serial abdominal x-rays after administration of radiopaque…”
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Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients by Rios, A, Stringfellow, D A, Fitzpatrick, F A, Reele, S B, Gutknecht, G D, Hersh, E M

“…2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) was given to 59 patients in a Phase I study. The agent was selected because it is an interferon inducer and…”
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Total suppression of ventricular arrhythmias by encainide. Pharmacokinetic and electrocardiographic characteristics by Roden, D M, Reele, S B, Higgins, S B, Mayol, R F, Gammans, R E, Oates, J A, Woosley, R L

“…We studied the antiarrhythmic effect of a range of oral doses of encainide in 11 patients with stable high-frequency ventricular arrhythmias. Total suppression…”
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