Non-coherent light for photodynamic therapy of superficial tumours in animals
Cultured 9L cells were incubated with varying concentrations of pheophorbide‐a‐hexyl ether (HPPH) and then exposed to 665‐nm red light from a non‐coherent light source or a dye laser. Cell death was produced by both light sources, with the non‐coherent light being most effective at the highest HPPH...
Saved in:
| Published in: | Veterinary & comparative oncology Vol. 2; no. 3; pp. 157 - 163 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK; Malden, USA
Blackwell Science Ltd
01-09-2004
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Cultured 9L cells were incubated with varying concentrations of pheophorbide‐a‐hexyl ether (HPPH) and then exposed to 665‐nm red light from a non‐coherent light source or a dye laser. Cell death was produced by both light sources, with the non‐coherent light being most effective at the highest HPPH concentrations. To assess the feasibility of using the non‐coherent light source for clinical photodynamic therapy (PDT), four dogs and three cats presenting with spontaneous superficial tumours were injected intravenously with 0.15 mg kg−1 of HPPH, 1 h before their tumours were irradiated with 665‐nm non‐coherent light (50 mW cm−2, 100 J cm−2). Of the nine tumours treated, there were eight complete responses, all occurring in animals with squamous cell carcinoma. After 68 weeks of follow‐up, the median initial disease‐free interval had not been reached. These data suggest that non‐coherent light sources may be efficacious for photodynamic therapy of spontaneous superficial tumours in animals, representing a cost‐effective alternative to medical lasers in both veterinary and human oncology. |
|---|---|
| Bibliography: | ark:/67375/WNG-P4T8JTQR-D ArticleID:VCO052 istex:C1FA00245ADFE3EF811C527F4570C08600189788 Present address: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN, USA. These data were presented, in part, at the BiOS ‘04 International Biomedical Optics Symposium, Photonics West Conference, San Jose, CA, January, 2004. Present address: Department of Psychiatry and Behavioural Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Present address: Sciperio, Inc, Orlando, FL, USA. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1476-5810 1476-5829 |
| DOI: | 10.1111/j.1476-5810.2004.00052.x |