Search Results - "Reeder, Kristen M."
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Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
Published in Proceedings of the National Academy of Sciences - PNAS (17-09-2013)“…Antifolates, folate analogs that inhibit vitamin B ₉ (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and…”
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IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection
Published in The Journal of immunology (1950) (15-09-2017)“…Members of the IL-1 family play protective and regulatory roles in immune defense against the opportunistic mold Aspergillus fumigatus. In this study, we…”
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Isolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus
Published in mBio (28-06-2022)“…Yellow fever virus (YFV) causes sporadic outbreaks of infection in South America and sub-Saharan Africa. While live-attenuated yellow fever virus vaccines…”
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IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E 2 during Lung Fungal Infection
Published in The Journal of immunology (1950) (15-09-2017)“…Members of the IL-1 family play protective and regulatory roles in immune defense against the opportunistic mold In this study, we investigated the IL-1 family…”
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Acidic Mammalian Chitinase Negatively Affects Immune Responses during Acute and Chronic Aspergillus fumigatus Exposure
Published in Infection and immunity (01-07-2018)“…Chitin is a polysaccharide that provides structure and rigidity to the cell walls of fungi and insects. Mammals possess multiple chitinases, which function to…”
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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress
Published in Cell (19-08-2021)“…Alphaviruses cause severe arthritogenic or encephalitic disease. The E1 structural glycoprotein is highly conserved in these viruses and mediates viral fusion…”
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Role of Common γ-Chain Cytokines in Lung Interleukin-22 Regulation after Acute Exposure to Aspergillus fumigatus
Published in Infection and immunity (01-10-2018)“…Humans are constantly exposed to the opportunistic mold , and disease caused by this pathogen is often determined by the magnitude of local and systemic immune…”
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The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma
Published in Mucosal immunology (01-09-2018)“…Asthmatics sensitized to fungi are reported to have more severe asthma, yet the immunopathogenic pathways contributing to this severity have not been…”
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IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation
Published in JCI insight (01-11-2019)“…Severe asthma with fungal sensitization (SAFS) defines a subset of human asthmatics with allergy to 1 or more fungal species and difficult-to-control asthma…”
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The contribution of acidic mammalian chitinase to disease severity in experimental fungal asthma
Published in The Journal of immunology (1950) (01-05-2017)“…Chitin is a polysaccharide that provides structure and rigidity to the fungal cell wall. Exposure to A. fumigatus cell wall moieties such as chitin has been…”
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Journal Article -
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IL-33 signaling regulates innate IL-22 production via suppression of PGE2 during lung fungal infection
Published in The Journal of immunology (1950) (01-05-2017)“…Members of the IL-1 family play both protective and regulatory roles in immune defense against the opportunistic mold Aspergillus fumigatus. Here, we…”
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Journal Article -
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IL-33 signaling regulates innate IL-17A and IL-22 production via suppression of PGE2 during lung fungal infection
Published in The Journal of immunology (1950) (07-08-2017)“…Members of the IL-1 family play protective and regulatory roles in immune defense against the opportunistic mold Aspergillus fumigatus . Here, we investigated…”
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Journal Article -
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Uncovering the Role of Common Gamma-Chain Cytokines in Aspergillus fumigatus Associated Diseases
Published 01-01-2017“…Fungal pathogens contribute to a wide range of diseases that are largely dependent on the host’s immune state. In the case of immune suppression, Aspergillus…”
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Imaging findings of Menkes disease, a radiographic mimic of abusive trauma
Published in Radiology case reports (01-08-2019)“…Menkes disease is a rare X-linked recessive disorder caused by impaired copper absorption and transport. Presented here is a case of a 12-week-old male who…”
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Journal Article