Search Results - "Reed, Steven"

Key roles of adjuvants in modern vaccines by Reed, Steven G, Orr, Mark T, Fox, Christopher B

“…Adjuvants play an important part in vaccines, as they can enhance and shape antigen-specific immune responses. This Review discusses the benefits of adjuvants…”
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A synthetic adjuvant to enhance and expand immune responses to influenza vaccines by Coler, Rhea N, Baldwin, Susan L, Shaverdian, Narek, Bertholet, Sylvie, Reed, Steven J, Raman, Vanitha S, Lu, Xiuhua, DeVos, Joshua, Hancock, Kathy, Katz, Jacqueline M, Vedvick, Thomas S, Duthie, Malcolm S, Clegg, Christopher H, Van Hoeven, Neal, Reed, Steven G

“…Safe, effective adjuvants that enhance vaccine potency, including induction of neutralizing Abs against a broad range of variant strains, is an important…”
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Ubiquitin ligases and cell cycle control by Teixeira, Leonardo K, Reed, Steven I

“…The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to cell division known as the cell cycle. Not only does…”
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Make it a combo by Reed, Steven G, Carter, Darrick

“…Adjuvants that combine TLR agonists and inflammatory agonists promote robust and durable vaccine responses (Bechtold . and Arunachalam .)…”
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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant by Coler, Rhea N, Bertholet, Sylvie, Moutaftsi, Magdalini, Guderian, Jeff A, Windish, Hillarie Plessner, Baldwin, Susan L, Laughlin, Elsa M, Duthie, Malcolm S, Fox, Christopher B, Carter, Darrick, Friede, Martin, Vedvick, Thomas S, Reed, Steven G

“…Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of gram-negative bacterial cell walls, are driven by Toll-like…”
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Use of defined TLR ligands as adjuvants within human vaccines by Duthie, Malcolm S., Windish, Hillarie Plessner, Fox, Christopher B., Reed, Steven G.

“…Our improved understanding of how innate immune responses can be initiated and how they can shape adaptive B‐ and T‐cell responses is having a significant…”
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New horizons in adjuvants for vaccine development by Reed, Steven G, Tomai, Mark, Gale, Michael J

“…Adjuvant molecules, particularly toll like receptor (TLR) agonists have been in development for decades, though until now only a natural TLR 4 ligand…”
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Adjuvants for human vaccines by Alving, Carl R, Peachman, Kristina K, Rao, Mangala, Reed, Steven G

“…Highlights ► Formulations of adjuvants can have different properties than individual adjuvants. ► Beneficial adjuvant formulations can be made with alum, oil…”
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Real-time PCR in detection and quantitation of Leishmania donovani for the diagnosis of Visceral Leishmaniasis patients and the monitoring of their response to treatment by Hossain, Faria, Ghosh, Prakash, Khan, Md Anik Ashfaq, Duthie, Malcolm S, Vallur, Aarthy C, Picone, Alessandro, Howard, Randall F, Reed, Steven G, Mondal, Dinesh

“…Sustained elimination of Visceral Leishmaniasis (VL) requires the reduction and control of parasite reservoirs to minimize the transmission of Leishmania…”
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Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL‐18, and IFN‐γ by Desbien, Anthony L., Reed, Steven J., Bailor, Hilton R., Cauwelaert, Natasha Dubois, Laurance, John D., Orr, Mark T., Fox, Christopher B., Carter, Darrick, Reed, Steven G., Duthie, Malcolm S.

“…The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) is a potent Th1‐response‐inducing adjuvant when formulated in a squalene oil‐in‐water emulsion…”
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Adjuvants for cancer vaccines by Dubensky, Thomas W, Reed, Steven G

“…Abstract The recent FDA approval of sipuleucel-T (Provenge® ), a patient-specific immunotherapy for androgen-independent prostate cancer developed by Dendreon…”
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New horizons in adjuvants for vaccine development by Reed, Steven G, Bertholet, Sylvie, Coler, Rhea N, Friede, Martin

“…Over the last decade, there has been a flurry of research on adjuvants for vaccines, and several novel adjuvants are now in licensed products or in late stage…”
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An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates by Erasmus, Jesse H, Khandhar, Amit P, O'Connor, Megan A, Walls, Alexandra C, Hemann, Emily A, Murapa, Patience, Archer, Jacob, Leventhal, Shanna, Fuller, James T, Lewis, Thomas B, Draves, Kevin E, Randall, Samantha, Guerriero, Kathryn A, Duthie, Malcolm S, Carter, Darrick, Reed, Steven G, Hawman, David W, Feldmann, Heinz, Gale, Jr, Michael, Veesler, David, Berglund, Peter, Fuller, Deborah Heydenburg

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a…”
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First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria by Mordmüller, Benjamin, Sulyok, Mihály, Egger-Adam, Diane, Resende, Mafalda, de Jongh, Willem A, Jensen, Mette H, Smedegaard, Helle Holm, Ditlev, Sisse B, Soegaard, Max, Poulsen, Lars, Dyring, Charlotte, Calle, Carlos Lamsfus, Knoblich, Annette, Ibáñez, Javier, Esen, Meral, Deloron, Philippe, Ndam, Nicaise, Issifou, Saadou, Houard, Sophie, Howard, Randall F, Reed, Steven G, Leroy, Odile, Luty, Adrian J F, Theander, Thor G, Kremsner, Peter G, Salanti, Ali, Nielsen, Morten A

“…Abstract Background Malaria in pregnancy has major impacts on mother and child health. To complement existing interventions, such as intermittent preventive…”
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IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants by Desbien, Anthony L, Dubois Cauwelaert, Natasha, Reed, Steven J, Bailor, Hilton R, Liang, Hong, Carter, Darrick, Duthie, Malcolm S, Fox, Christopher B, Reed, Steven G, Orr, Mark T

“…Designing modern vaccine adjuvants depends on understanding the cellular and molecular events that connect innate and adaptive immune responses. The synthetic…”
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Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model by Baldwin, Susan L, Reese, Valerie A, Larsen, Sasha E, Beebe, Elyse, Guderian, Jeff, Orr, Mark T, Fox, Christopher B, Reed, Steven G, Coler, Rhea N

“…An estimated 10 million people developed tuberculosis (TB) disease in 2019 which underscores the need for a vaccine that prevents disease and reduces…”
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A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika by Erasmus, Jesse H., Khandhar, Amit P., Guderian, Jeff, Granger, Brian, Archer, Jacob, Archer, Michelle, Gage, Emily, Fuerte-Stone, Jasmine, Larson, Elise, Lin, Susan, Kramer, Ryan, Coler, Rhea N., Fox, Christopher B., Stinchcomb, Dan T., Reed, Steven G., Van Hoeven, Neal

“…Since the first demonstration of in vivo gene expression from an injected RNA molecule almost two decades ago,1 the field of RNA-based therapeutics is now…”
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Patronage and Predominance: How the LDP Maintains Its Hold on Power by REED, Steven R

“…Abstract The Liberal Democratic Party (LDP) held power from 1955 until 1993. How did it manage to do so? In 1994 a political reform resulted in competitive…”
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Skin tests for the detection of Mycobacterial infections: achievements, current perspectives, and implications for other diseases by Duthie, Malcolm S., Reed, Steven G.

“…Immunological and molecular advances have modernized diagnostic testing for many diseases. Although interferon gamma-release and polymerase chain reaction…”
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Cyclin E Deregulation Promotes Loss of Specific Genomic Regions by Teixeira, Leonardo K., Wang, Xianlong, Li, Yongjiang, Ekholm-Reed, Susanna, Wu, Xiaohua, Wang, Pei, Reed, Steven I.

“…Cell-cycle progression is regulated by the cyclin-dependent kinase (Cdk) family of protein kinases, so named because their activation depends on association…”
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