Search Results - "Reed, J. C."

Proapoptotic multidomain Bcl-2 Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities by Reed, J C

“…Bcl-2-family proteins are central regulators of cell life and death. At least three major classes of Bcl-2-family proteins have been delineated, including…”
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A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy by Placzek, W J, Wei, J, Kitada, S, Zhai, D, Reed, J C, Pellecchia, M

“…We investigated the mRNA expression levels of all six antiapoptotic Bcl-2 subfamily members in 68 human cancer cell lines using qPCR techniques and measured…”
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Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins by Zhai, D, Jin, C, Satterthwait, A C, Reed, J C

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IAP family proteins--suppressors of apoptosis by Deveraux, Q L, Reed, J C

“…Apoptosis is a physiological cell suicide program that is critical for the development and maintenance of healthy tissues. Dysregulation of cell death pathways…”
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Dysregulation of Apoptosis in Cancer by REED, J. C

“…Each day, approximately 50 to 70 billion cells perish in the average adult because of programmed cell death (PCD). Cell death in self-renewing tissues, such as…”
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Three-dimensional structure of Bax-mediated pores in membrane bilayers by Xu, X-P, Zhai, D, Kim, E, Swift, M, Reed, J C, Volkmann, N, Hanein, D

“…B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis…”
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Bcl-2 and the Regulation of Programmed Cell Death by Reed, John C.

“…Programmed cell death (PCD) is used to describe a mechanism of cellular demise that is believed to play an important role in a wide variety of physiological…”
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Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants by Malkesman, O, Austin, D R, Tragon, T, Henter, I D, Reed, J C, Pellecchia, M, Chen, G, Manji, H K

“…The BH3-interacting domain death agonist (Bid) is a pro-apoptotic member of the B-cell lymphoma-2 (Bcl-2) protein family. Previous studies have shown that…”
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The Survivin saga goes in vivo by Reed, J C

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Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt by HAN, Y.-H, CAO, X, LIN, B, LIN, F, KOLLURI, S. K, STEBBINS, J, REED, J. C, DAWSON, M. I, ZHANG, X.-K

“…Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77…”
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Mitochondria-dependent apoptosis and cellular pH regulation by Matsuyama, S, Reed, J C

“…Mitochondria play a critical role in apoptosis induction in response to myriad stimuli. These organelles release proteins into the cytosol which trigger…”
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Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3 by Li, Hui, Kolluri, Siva Kumar, Gu, Jian, Dawson, Marcia I., Cao, Xihua, Hobbs, Peter D., Lin, Bingzhen, Chen, Guo-quen, Lu, Jiang-song, Lin, Feng, Xie, Zhihua, Fontana, Joseph A., Reed, John C., Zhang, Xiao-kun

“…TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates…”
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Molecular chaperone targeting and regulation by BAG family proteins by Takayama, Shinichi, Reed, John C

“…Regulated changes in protein conformation can have profound effects on protein function, although routine laboratory methods often fail to detect them. The…”
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Bcl-2 family proteins and cancer by Yip, K W, Reed, J C

“…BCL-2 was the first anti-death gene discovered, a milestone with far reaching implications for tumor biology. Multiple members of the human Bcl-2 family of…”
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Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies by Reed, J C

“…Nearly all anticancer drugs presently available to clinicians kill tumor cells by activating an endogenous biochemical pathway for cell suicide, known as…”
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p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis by Schürmann, A, Mooney, A F, Sanders, L C, Sells, M A, Wang, H G, Reed, J C, Bokoch, G M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bcl-2 Oncoprotein Blocks Chemotherapy-Induced Apoptosis in a Human Leukemia Cell Line by Miyashita, Toshiyuki, Reed, John C.

“…Previous studies have shown that the bcl-2 gene encodes a mitochondrial protein that contributes to neoplastic cell expansion primarily by promoting cell…”
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IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), bax, caspases, and anticancer drugs by TAMM, I, YAN WANG, SAUSVILLE, E, SCUDIERO, D. A, VIGNA, N, OLTERSDORF, T, REED, J. C

“…Survivin is a member of the inhibitor of apoptosis protein (IAP) family. We investigated the antiapoptotic mechanism of Survivin, as well as its expression in…”
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The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells by LUCAS, D. M, DAVIS, M. E, GREVER, M. R, PARTHUN, M. R, MONE, A. P, KITADA, S, CUNNINGHAM, K. D, FLAX, E. L, WICKHAM, J, REED, J. C, BYRD, J. C

“…MS-275 is a histone deacetylase (HDAC) inhibitor that has been reported to mediate its cytotoxic effect through generation of reactive oxygen species (ROS) in…”
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Ionizing radiation enhances therapeutic activity of mda-7/IL-24 : overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2 by SU, Z.-Z, LEBEDEVA, I. V, SARKAR, D, EMDAD, L, GUPTA, P, KITADA, S, DENT, P, REED, J. C, FISHER, P. B

“…Subtraction hybridization applied to terminally differentiating human melanoma cells identified mda-7/IL-24, a cytokine belonging to the IL-10 gene…”
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