Search Results - "Redwood, C S"

Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy by REDWOOD, C. S, MOOLMAN-SMOOK, J. C, WATKINS, H

“…Hypertrophic cardiomyopathy (HCM) is one of the most frequently occurring inherited cardiac disorders, affecting up to 1 in 500 of the population. Molecular…”
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A Mutant Tropomyosin That Causes Hypertrophic Cardiomyopathy Is Expressed In Vivo and Associated With an Increased Calcium Sensitivity by Bottinelli, R, Coviello, D.A, Redwood, C.S, Pellegrino, M.A, Maron, B.J, Spirito, P, Watkins, H, Reggiani, C

“…Mutant contractile protein genes that cause familial hypertrophic cardiomyopathy (FHC) are presumed to encode mutant proteins that interfere with contractile…”
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The molecular anatomy of caldesmon by MARSTON, S. B, REDWOOD, C. S

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The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon by MARSTON, S. B, REDWOOD, C. S

“…We compared the mechanisms by which caldesmon inhibits actin and actin-tropomyosin activation of myosin subfragment 1 (S1) MgATPase activity. Caldesmon always…”
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Binding and regulatory properties of expressed functional domains of chicken gizzard smooth muscle caldesmon by Redwood, C.S., Marston, S.B.

“…We expressed the following fragments of chicken gizzard caldesmon in the pMW 172/BL21 (DE3) system at 0.4-2.2 mg of pure protein/liter of culture: full-length…”
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The Effect of the Arg91Gly and Glu139del Mutations in β-Tropomyosin Associated with Congenital Myopathy of Human Skeletal Muscles on Actin–Myosin Interaction by Rysev, N. A., Karpicheva, O. E., Sirenko, V. V., Simonyan, A. O., Redwood, C. S., Borovikov, Y. S.

“…The structural changes in proteins of the contractile apparatus of muscle fiber and the violation of their function due to point mutations in these proteins…”
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Modulation of Thin Filament Activation by Breakdown or Isoform Switching of Thin Filament Proteins: Physiological and Pathological Implications by Marston, Steven B, Redwood, Charles S

“…ABSTRACT—In the heart, the contractile apparatus is adapted to the specific demands of the organ for continuous rhythmic contraction. The specialized…”
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Altered Regulatory Properties of Human Cardiac Troponin I Mutants That Cause Hypertrophic Cardiomyopathy by Elliott, Kathryn, Watkins, Hugh, Redwood, Charles S.

“…Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex and is involved in the calcium control of heart muscle contraction. Recently,…”
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Synchronous in situ ATPase activity, mechanics, and Ca2+ sensitivity of human and porcine myocardium by Griffiths, P J, Isackson, H, Pelc, R, Redwood, C S, Funari, S S, Watkins, H, Ashley, C C

“…Flash-frozen myocardium samples provide a valuable means of correlating clinical cardiomyopathies with abnormalities in sarcomeric contractile and biochemical…”
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Inhibition of actin-tropomyosin activation of myosin MgATPase activity by the smooth muscle regulatory protein caldesmon by Marston, S B, Redwood, C S

“…Caldesmon inhibition of actin-tropomyosin activation of myosin MgATPase activity was investigated. greater than 90% inhibition of ATPase activation correlated…”
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Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone by HUBER, P. A. J, REDWOOD, C. S, AVENT, N. D, TANNER, M. J. A, MARSTON, S. B

“…A partial clone of caldesmon, coding for the C-terminal 288 amino acids, was isolated from a human fetal liver cDNA library and sequenced. Expression of the…”
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Reversal of caldesmon function by anti-caldesmon antibodies confirms its role in the calcium regulation of vascular smooth muscle thin filaments by Marston, S B, Redwood, C S, Lehman, W

“…Direct evidence that caldesmon is the Ca2+-regulated inhibitory component of native smooth muscle thin filaments is provided by studies using…”
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The functional properties of full length and mutant chicken gizzard smooth muscle caldesmon expressed in Escherichia coli by Redwood, C.S., Marston, S.B., Bryan, J., Cross, R.A., Kendrick-Jones, J.

“…Wild type chicken gizzard caldesmon (756 amino acids) was expressed in a T7 RNA polymerase-based bacterial expression system at a yield of 1 mg pure caldesmon…”
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Effects of troponin C isoform on the action of the cardiotonic agent EMD 57033 by Lipscomb, Simon, Preston, Laura C, Robinson, Paul, Redwood, Charles S, Mulligan, Ian P, Ashley, Christopher C

“…The effects of the cardiotonic potentiator EMD 57033 on different TnC (troponin C) isoforms were investigated. Endogenous skeletal TnC was extracted from…”
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Effects of Two Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin, Asp175Asn and Glu180Gly, on Ca2+Regulation of Thin Filament Motility by Bing, Wu, Redwood, Charles S., Purcell, Ian F., Esposito, Giovanna, Watkins, Hugh, Marston, Steven B.

“…The functional properties of wild type α-tropomyosin expressed in E. coli with an alanine-serine N-terminal leader (AS-α-Tm) were compared with those of…”
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The functional effects of mutations Thr673→Asp and Ser702→Asp at the pro-directed kinase phosphorylation sites in the C-terminus of chicken gizzard caldesmon by REDWOOD, C. S, MARSTON, S. B, GUSEV, N. B

“…We expressed the C-terminal 99 amino acids of chicken gizzard caldesmon (658C) and two point mutants in which the preferred phosphorylation sites of MAP kinase…”
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Synchronous In Situ ATPase Activity, Mechanics, and Ca super(2+) Sensitivity of Human and Porcine Myocardium by Griffiths, P J, Isackson, H, Pelc, R, Redwood, C S, Funari, S S, Watkins, H, Ashley, C C

“…Flash-frozen myocardium samples provide a valuable means of correlating clinical cardiomyopathies with abnormalities in sarcomeric contractile and biochemical…”
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Dilated cardiomyopathy mutations in α-tropomyosin inhibit its movement during the ATPase cycle by Borovikov, Yurii S., Karpicheva, Olga E., Chudakova, Galina A., Robinson, Paul, Redwood, Charles S.

“…The Glu40Lys and Glu54Lys mutations in α-tropomyosin cause dilated cardiomyopathy (DCM). Functional analysis has demonstrated that both mutations decrease thin…”
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Phosphorylation of aorta caldesmon by endogeneous proteolytic fragments of protein kinase C by Vorotnikov, A. V., Gusev, N. B., Hua, S., Collins, J. H., Redwood, C. S., Marston, S. B.

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Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies by Borovikov, Iu S, Karpicheva, O E, Rysev, N A, Redwood, C S

“…Pathogenesis of most myopathies including inherited hypertrophic (HCM) and dilated (DCM) cardiomyopathies is based on modification of structural state of…”
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