Search Results - "Redwood, Alec J."

What's next in cancer immunotherapy? - The promise and challenges of neoantigen vaccination by Redwood, Alec J., Dick, Ian M., Creaney, Jenette, Robinson, Bruce W. S.

“…The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells, that when expressed, have the potential to be tumor-specific immune…”
Get full text

How Our Continuing Studies of the Pre-clinical Inbred Mouse Models of Mesothelioma Have Influenced the Development of New Therapies by Robinson, Bruce W S, Redwood, Alec J, Creaney, Jenette

“…Asbestos-induced preclinical mouse models of mesothelioma produce tumors that are very similar to those that develop in humans and thus represent an ideal…”
Get full text

New genetic predictors for abacavir tolerance in HLA-B57:01 positive individuals by Pavlos, Rebecca, Deshpande, Pooja, Chopra, Abha, Leary, Shay, Strautins, Kaija, Nolan, David, Thorborn, Daren, Shaefer, Mark, Rauch, Andri, Dunn, David, Montaner, Julio, Rachlis, Anita, Almeida, Coral-Ann, Choo, Linda, James, Ian, Redwood, Alec J., Li, Yueran, Gaudieri, Silvana, Mallal, Simon A., Phillips, Elizabeth J.

“…Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative…”
Get full text

The Role of IL-22 in Viral Infections: Paradigms and Paradoxes by Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A, Redwood, Alec J, Humphreys, Ian R

“…Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric…”
Get full text

Memory Inflation Drives Tissue-Resident Memory CD8 + T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus by Morabito, Kaitlyn M, Ruckwardt, Tracy J, Bar-Haim, Erez, Nair, Deepika, Moin, Syed M, Redwood, Alec J, Price, David A, Graham, Barney S

“…Tissue-resident memory T (T ) cells provide first-line defense against invading pathogens encountered at barrier sites. In the lungs, T cells protect against…”
Get full text

A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment by Zhou, Yue-Peng, Mei, Meng-Jie, Wang, Xian-Zhang, Huang, Sheng-Nan, Chen, Lin, Zhang, Ming, Li, Xin-Yan, Qin, Hai-Bin, Dong, Xiao, Cheng, Shuang, Wen, Le, Yang, Bo, An, Xue-Fang, He, Ao-Di, Zhang, Bing, Zeng, Wen-Bo, Li, Xiao-Jun, Lu, Youming, Li, Hong-Chuang, Li, Haidong, Zou, Wei-Guo, Redwood, Alec J, Rayner, Simon, Cheng, Han, McVoy, Michael A, Tang, Qiyi, Britt, William J, Zhou, Xin, Jiang, Xuan, Luo, Min-Hua

“…Congenital cytomegalovirus (cCMV) infection is the leading infectious cause of neurodevelopmental disorders. However, the neuropathogenesis remains largely…”
Get full text

Natural killer cell dependent within-host competition arises during multiple MCMV infection: consequences for viral transmission and evolution by McWhorter, Andrea R, Smith, Lee M, Masters, Laura L, Chan, Baca, Shellam, Geoffrey R, Redwood, Alec J

“…It is becoming increasingly clear that many diseases are the result of infection from multiple genetically distinct strains of a pathogen. Such multi-strain…”
Get full text

The m15 Locus of Murine Cytomegalovirus Modulates Natural Killer Cell Responses to Promote Dissemination to the Salivary Glands and Viral Shedding by Chan, Baca, Arapović, Maja, Masters, Laura L., Rwandamuiye, Francois, Jonjić, Stipan, Smith, Lee M., Redwood, Alec J.

“…As the largest herpesviruses, the 230 kb genomes of cytomegaloviruses (CMVs) have increased our understanding of host immunity and viral escape mechanisms,…”
Get full text

Abacavir inhibits but does not cause self-reactivity to HLA-B57:01-restricted EBV specific T cell receptors by Sooda, Anuradha, Rwandamuriye, Francois, Wanjalla, Celestine N., Jing, Lichen, Koelle, David M., Peters, Bjoern, Leary, Shay, Chopra, Abha, Calderwood, Michael A., Mallal, Simon A., Pavlos, Rebecca, Watson, Mark, Phillips, Elizabeth J., Redwood, Alec J.

“…Pre-existing pathogen-specific memory T cell responses can contribute to multiple adverse outcomes including autoimmunity and drug hypersensitivity. How the…”
Get full text

HLA-A32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms by Konvinse, Katherine C., Trubiano, Jason A., Pavlos, Rebecca, James, Ian, Shaffer, Christian M., Bejan, Cosmin A., Schutte, Ryan J., Ostrov, David A., Pilkinton, Mark A., Rosenbach, Misha, Zwerner, Jeffrey P., Williams, Kristina B., Bourke, Jack, Martinez, Patricia, Rwandamuriye, Francois, Chopra, Abha, Watson, Mark, Redwood, Alec J., White, Katie D., Mallal, Simon A., Phillips, Elizabeth J.

“…Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which leads to…”
Get full text

Use of a Murine Cytomegalovirus K181-Derived Bacterial Artificial Chromosome as a Vaccine Vector for Immunocontraception by REDWOOD, Alec J, MESSERLE, Martin, HARVEY, Nicole L, HARDY, Christopher M, KOSZINOWSKI, Ulrich H, LAWSON, Malcolm A, SHELLAM, Geoffrey R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8 + T cells by Delpoux, Arnaud, Michelini, Rodrigo Hess, Verma, Shilpi, Lai, Chen-Yen, Omilusik, Kyla D, Utzschneider, Daniel T, Redwood, Alec J, Goldrath, Ananda W, Benedict, Chris A, Hedrick, Stephen M

“…Upon infection with an intracellular pathogen, cytotoxic CD8 T cells develop diverse differentiation states characterized by function, localization, longevity,…”
Get full text

Murine cytomegalovirus disseminates independently of CX3CR1, CCL2 or its m131/m129 chemokine homologue by Farrell, Helen E, Bruce, Kimberley, Redwood, Alec J, Stevenson, Philip G

“…Cytomegaloviruses (CMVs) use myeloid cells to move within their hosts. Murine CMV (MCMV) colonizes the salivary glands for long-term shedding, and reaches them…”
Get full text

Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions by Karnes, Jason H, Miller, Matthew A, White, Katie D, Konvinse, Katherine C, Pavlos, Rebecca K, Redwood, Alec J, Peter, Jonathan G, Lehloenya, Rannakoe, Mallal, Simon A, Phillips, Elizabeth J

“…Adverse drug reactions (ADRs) are a significant health care burden. Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but…”
Get full text

Self-disseminating vaccines for emerging infectious diseases by Murphy, Aisling A, Redwood, Alec J, Jarvis, Michael A

“…Modern human activity fueled by economic development is profoundly altering our relationship with microorganisms. This altered interaction with microbes is…”
Get more information

Membrane association of a model CD4+ T‐cell vaccine antigen confers enhanced yet incomplete protection against murid herpesvirus‐4 infection by Yunis, Joseph, Redwood, Alec J, Belz, Gabrielle T, Stevenson, Philip G

“…Vaccination against γ‐herpesviruses has proved difficult. CD4+ T cells are essential to contain infection, but how best to prime them and whether this can…”
Get full text

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors by Železnjak, Jelena, Lisnić, Vanda Juranić, Popović, Branka, Lisnić, Berislav, Babić, Marina, Halenius, Anne, L'Hernault, Anne, Roviš, Tihana Lenac, Hengel, Hartmut, Erhard, Florian, Redwood, Alec J, Vidal, Silvia M, Dölken, Lars, Krmpotić, Astrid, Jonjić, Stipan

“…CMVs efficiently target MHC I molecules to avoid recognition by cytotoxic T cells. However, the lack of MHC I on the cell surface renders the infected cell…”
Get full text

Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice ( Mastomys natalensis ) by Hansen, Frederick, Vučak, Matej, Nichols, Jenna, Hughes, Joseph, Bane, Sidy, Camiolo, Salvatore, da Silva Filipe, Ana, Ostermann, Eleonore, Staliunaite, Laura, Chan, Baca, Mauch, Thekla, Sogoba, Nafomon, Streblow, Daniel N, Voigt, Sebastian, Oestereich, Lisa, Ehlers, Bernhard, Redwood, Alec J, Feldmann, Heinz, Brune, Wolfram, Rosenke, Kyle, Jarvis, Michael A, Davison, Andrew J

“…Distinct cytomegaloviruses (CMVs) are widely distributed across their mammalian hosts in a highly host species-restricted pattern. To date, evidence…”
Get full text

Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses by Jing, Lichen, Laing, Kerry J, Dong, Lichun, Russell, Ronnie M, Barlow, Russell S, Haas, Juergen G, Ramchandani, Meena S, Johnston, Christine, Buus, Soren, Redwood, Alec J, White, Katie D, Mallal, Simon A, Phillips, Elizabeth J, Posavad, Christine M, Wald, Anna, Koelle, David M

“…The Alphaherpesvirinae subfamily includes HSV types 1 and 2 and the sequence-divergent pathogen varicella zoster virus (VZV). T cells, controlled by TCR and…”
Get full text

The Combined Utility of Ex Vivo IFN-γ Release Enzyme-Linked ImmunoSpot Assay and In Vivo Skin Testing in Patients with Antibiotic-Associated Severe Cutaneous Adverse Reactions by Trubiano, Jason A., Strautins, Kaija, Redwood, Alec J., Pavlos, Rebecca, Konvinse, Katherine C., Aung, Ar Kar, Slavin, Monica A., Thursky, Karin A., Grayson, M. Lindsay, Phillips, Elizabeth J.

“…For severe cutaneous adverse reactions (SCARs) associated with multiple antibiotics dosed concurrently, clinical causality is challenging and diagnostic…”
Get full text