Search Results - "Redston, M S"

Frequent somatic mutations and homozygous deletions of the p16 ( MTS1 ) gene in pancreatic adenocarcinoma by Caldas, Carlos, Hahn, Stephan A, da Costa, Luis T, Redston, Mark S, Schutte, Mieke, Seymour, Albert B, Weinstein, Craig L, Hruban, Ralph H, Yeo, Charles J, Kern, Scott E

“…The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic…”
Get full text

p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma by DiGiuseppe, JA, Redston, MS, Yeo, CJ, Kern, SE, Hruban, RH

“…The p53 tumor suppressor gene is mutated in the majority of pancreatic adenocarcinomas, and several studies have suggested that loss of p53 function may…”
Get full text

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions by REDSTON, M. S, CALDAS, C, SEYMOUR, A. B, HRUBAN, R. H, DA COSTA, L, YEO, C. J, KERN, S. E

“…Pancreatic adenocarcinoma is a major cause of cancer death, and yet little is known about its molecular pathogenesis. We identified p53 mutations in 19 (70%)…”
Get full text

Allelotype of pancreatic adenocarcinoma using xenograft enrichment by HAHN, S. A, SEYMOUR, A. B, HRUBAN, R. H, KERN, S. E, HOQUE, A. T. M. S, SCHUTTE, M, DA COSTA, L. T, REDSTON, M. S, CALDAS, C, WEINSTEIN, C. L, FISCHER, A, YEO, C. J

“…p53 and MTS1 are known to be mutationally inactivated in pancreatic adenocarcinoma. Other tumor suppressor genes are likely also to play a role. To define…”
Get full text

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia by CALDAS, C, HAHN, S. A, HRUBAN, R. H, REDSTON, M. S, YEO, C. J, KERN, S. E

“…Pancreatic adenocarcinoma is the fifth leading cause of cancer death in the United States. Mutations in the K-ras oncogene occur in 85% of pancreatic…”
Get full text

Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias by Redston, M S, Papadopoulos, N, Caldas, C, Kinzler, K W, Kern, S E

“…Chronic colitis is associated with an increased risk of colorectal neoplasia, creating a need for early diagnosis in this population. Little is yet known of…”
Get more information

Klenow co-sequencing: a method for eliminating "stops" by Redston, M S, Kern, S E

Get more information

Patients with both pancreatic adenocarcinoma and melanoma may harbor germline CDKN2A mutations by Lal, Geeta, Liu, Ling, Hogg, David, Lassam, Norman J., Redston, Mark S., Gallinger, Steven

“…Germline mutations of the CDKN2A tumor suppressor gene have been identified in melanoma kindreds linked to 9p21, and pancreatic adenocarcinoma is the second…”
Get full text

Both$p16^{Ink4a}$and the$p19^{Arf}-p53$Pathway Constrain Progression of Pancreatic Adenocarcinoma in the Mouse by Bardeesy, Nabeel, Aguirre, Andrew J., Chu, Gerald C., Cheng, Kuang-hung, Lopez, Lyle V., Hezel, Aram F., Feng, Bin, Brennan, Cameron, Weissleder, Ralph, Mahmood, Umar, Hanahan, Douglas, Redston, Mark S., Chin, Lynda, DePinho, Ronald A.

“…Activating KRAS mutations and$p16^{Ink4a}$inactivation are near universal events in human pancreatic ductal adenocarcinoma (PDAC). In mouse…”
Get full text

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma by Aguirre, Andrew J, Bardeesy, Nabeel, Sinha, Manisha, Lopez, Lyle, Tuveson, David A, Horner, James, Redston, Mark S, DePinho, Ronald A

“…Pancreatic ductal adenocarcinoma ranks among the most lethal of human malignancies. Here, we assess the cooperative interactions of two signature mutations in…”
Get full text

High-Resolution Characterization of the Pancreatic Adenocarcinoma Genome by Aguirre, Andrew J., Brennan, Cameron, Bailey, Gerald, Sinha, Raktim, Feng, Bin, Leo, Christopher, Zhang, Yunyu, Zhang, Jean, Gans, Joseph D., Bardeesy, Nabeel, Cauwels, Craig, Cordon-Cardo, Carlos, Redston, Mark S., DePinho, Ronald A., Chin, Lynda, Cantley, Lewis C.

“…The pancreatic adenocarcinoma genome harbors multiple amplifications and deletions, pointing to the existence of numerous oncogenes and tumor suppressor genes…”
Get full text

Prediction of response to temozolomide (TMZ)-based therapy by loss of MGMT expression in patients with advanced neuroendocrine tumors (NET) by Kulke, M. H., Frauenhoffer, C. S., Hooshmand, S. M., Ryan, D. P., Enzinger, P. C., Meyerhardt, J. A., Clark, J. W., Hornick, J., Fuchs, C. S., Redston, M. S.

“…Abstract only 4505 Background: TMZ, an oral alkylating agent, has recently been shown to be active in a subset of patients with NETs. In other tumor types,…”
Get full text

Successful treatment of cap polyposis with infliximab by Bookman, Ian D, Redston, Mark S, Greenberg, Gordon R

“…Cap polyposis is a disorder characterized by bloody diarrhea with rectosigmoid polyps covered by a cap of fibropurulent exudate. The pathogenesis is unknown,…”
Get full text

The hepatic von Meyenburg complex: prevalence and association with hepatic and renal cysts among 2843 autopsies [corrected] by Redston, M S, Wanless, I R

“…von Meyenburg complexes (VMC) are dilated small bile ducts surrounded by fibrous stroma. These lesions are frequently seen at autopsy, especially in…”
Get more information

Patients With Both Pancreatic Adenocarcinoma and Melanoma May Harbor Germline CDKN2A Mutations by Lal, G, Liu, L, Hogg, D, Lassam, N J, Redston, MS, Gallinger, S

“…Germline mutations of the CDKN2A tumor suppressor gene have been identified in melanoma kindreds linked to 9p21, and pancreatic adenocarcinoma is the second…”
Get full text